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1.发明申请公开(公告)号：US20120218854A1
公开(公告)日：2012-08-30
申请号：US13505469
申请日：2009-11-03
CPC分类号： B01F9/002 , B01F9/0005 , B01F11/0002 , B01F11/0005 , B01F15/00896 , B01F2009/0089 , B01F2009/0092 , G01N2035/00445 , G01N2035/00504 , G01N2035/0449 , G01N2035/0455
摘要： An apparatus for and method of enabling enhanced, selective agitation of liquid containing a solid-phase reagent. The apparatus includes at least one liquid-bearing container, a circular tray, and a motor. The liquid-bearing container(s) includes at least one internal baffle that imparts turbulent agitation to the liquid when flowing from one end of the container to an opposite end. The circular tray is adapted for selective rotation about a vertical axis of rotation. The rotary circular tray assembly includes container-receiving stations that selectively retain a respective liquid-bearing container in an inclined or pitched orientation with respect to a horizontal plane. The motor creates centrifugal force, which causes liquid in the container(s) to travel from the first end of the container to the second end of the container via the internal baffle(s), agitating the liquid and the solid-phase portions of the reagent. When gravitational force exceeds the centrifugal force, liquid in the container(s) travels from the second end of the container to the first end of the container via the internal baffle(s), again agitating the liquid and the solid-phase portions of the reagent.
摘要翻译： 一种能够增强选择性搅拌含有固相试剂的液体的装置和方法。 该装置包括至少一个液体承载容器，圆形托盘和马达。 液体承载容器包括至少一个内部挡板，当从容器的一端流到另一端时，其向液体施加湍流搅拌。 圆形托盘适于围绕垂直旋转轴线选择性旋转。 旋转圆盘组件包括容器接收站，该容器接收站相对于水平面选择性地保持相对于液体承载容器倾斜或倾斜的方向。 电动机产生离心力，其使容器中的液体经由内部挡板从容器的第一端行进到容器的第二端，搅拌液体和固体相的部分 试剂。 当重力超过离心力时，容器中的液体经由内部挡板从容器的第二端移动到容器的第一端，再次搅动液体和固体相的部分 试剂。
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公开(公告)号：US07534397B2
公开(公告)日：2009-05-19
申请号：US11608472
申请日：2006-12-08
申请人： Nicolae Dumitrescu
发明人： Nicolae Dumitrescu
IPC分类号： B01L3/00
CPC分类号： B01L3/5082 , B01L3/0272 , B01L2200/026 , B01L2300/046 , B01L2300/0851 , B01L2400/0638
摘要： The sample preparation device includes a vessel, such as a sample tube, having a bottom end with a bottom opening. A valve for control of the flow of any liquid outwardly of the vessel through the bottom opening is located at the bottom end of the vessel. The valve includes a deflectable membrane positioned against the bottom opening to close the bottom opening when the valve is in its normally closed condition. The membrane is deflectable away from the bottom opening when the valve is in an open condition to permit any liquid in the vessel to flow through the bottom opening to an outlet port of the valve for dispensation into a suitable collection vessel.
摘要翻译： 样品制备装置包括具有底部底部开口的容器，例如样品管。 用于控制通过底部开口的容器外部的任何液体的流动的阀位于容器的底端。 该阀包括可偏转的膜，该膜可以在阀处于其常闭状态时抵靠底部开口定位，以关闭底部开口。 当阀处于打开状态时，膜可以从底部开口偏转，以允许容器中的任何液体通过底部开口流动到阀的出口，用于分配到合适的收集容器中。
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公开(公告)号：US20080138251A1
公开(公告)日：2008-06-12
申请号：US11608472
申请日：2006-12-08
申请人： Nicolae DUMITRESCU
发明人： Nicolae DUMITRESCU
CPC分类号： B01L3/5082 , B01L3/0272 , B01L2200/026 , B01L2300/046 , B01L2300/0851 , B01L2400/0638
摘要： The sample preparation device includes a vessel, such as a sample tube, having a bottom end with a bottom opening. A valve for control of the flow of any liquid outwardly of the vessel through the bottom opening is located at the bottom end of the vessel. The valve includes a deflectable membrane positioned against the bottom opening to close the bottom opening when the valve is in its normally closed condition. The membrane is deflectable away from the bottom opening when the valve is in an open condition to permit any liquid in the vessel to flow through the bottom opening to an outlet port of the valve for dispensation into a suitable collection vessel.
摘要翻译： 样品制备装置包括具有底部底部开口的容器，例如样品管。 用于控制通过底部开口的容器外部的任何液体的流动的阀位于容器的底端。 该阀包括可偏转的膜，该膜可以在阀处于其常闭状态时抵靠底部开口定位，以关闭底部开口。 当阀处于打开状态时，膜可以从底部开口偏转，以允许容器中的任何液体通过底部开口流动到阀的出口，用于分配到合适的收集容器中。
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公开(公告)号：US10974213B2
公开(公告)日：2021-04-13
申请号：US13505469
申请日：2009-11-03
摘要： An apparatus for and method of enabling enhanced, selective agitation of liquid containing a solid-phase reagent. The apparatus includes at least one liquid-bearing container, a circular tray, and a motor. The liquid-bearing container(s) includes at least one internal baffle that imparts turbulent agitation to the liquid when flowing from one end of the container to an opposite end. The circular tray is adapted for selective rotation about a vertical axis of rotation. The rotary circular tray assembly includes container-receiving stations that selectively retain a respective liquid-bearing container in an inclined or pitched orientation with respect to a horizontal plane. The motor creates centrifugal force, which causes liquid in the container(s) to travel from the first end of the container to the second end of the container via the internal baffle(s), agitating the liquid and the solid-phase portions of the reagent. When gravitational force exceeds the centrifugal force, liquid in the container(s) travels from the second end of the container to the first end of the container via the internal baffle(s), again agitating the liquid and the solid-phase portions of the reagent.
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公开(公告)号：US20100310426A1
公开(公告)日：2010-12-09
申请号：US12675818
申请日：2008-08-27
CPC分类号： B01L3/563 , B01L3/5082 , B01L2200/16 , B01L2300/0672 , B01L2400/0478 , B01L2400/0683
摘要： A self dispensing reagent cartridge includes a vessel with a movable piston at one end and a puncturable self sealing septum at an opposite end. A hollow needle is located in alignment with the septum. The vessel is moved toward the needle to enable the needle to puncture the septum. The piston is then moved toward the septum to enable a predetermined amount of liquid in the vessel to be transferred outwardly of the vessel through the needle in an amount corresponding to the piston stroke.
摘要翻译： 自分配试剂盒包括在一端具有可移动活塞的容器和在相对端的可刺破的自密封隔膜。 空心针与隔膜对准。 将容器移动到针上，以使针能刺穿隔膜。 然后将活塞移向隔膜，以使容器中的预定量的液体以对应于活塞行程的量通过针向容器外部转移。
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公开(公告)号：USD413677S
公开(公告)日：1999-09-07
申请号：US080049
申请日：1997-11-26
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公开(公告)号：US08895267B2
公开(公告)日：2014-11-25
申请号：US12447932
申请日：2007-11-01
CPC分类号： C12Q1/686 , B01L3/5082 , B01L7/52 , B01L7/54 , B01L2200/025 , B01L2200/147 , B01L2300/0609 , B01L2300/0654 , B01L2300/10 , B01L2300/168 , B01L2300/1827 , B01L2300/1838 , B01L2300/1894 , C12Q1/6806
摘要： A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.
摘要翻译： 公开了一种用于聚合酶链式反应（PCR）测试的生物样品的随机存取，高通量系统和方法。 该系统包括核酸分离/纯化装置和PCR装置。 核酸分离/纯化装置从生物样品中磁性捕获核酸（NA）固体，然后将NA悬浮在洗脱缓冲溶液中。 PCR测试装置提供变性，退火和延长热循环的多个循环。 更具体地，PCR测试装置包括多容器热循环仪阵列，其具有多个单容器热循环器，每个单容器热循环器各自可热控制，使得相邻的单容器热循环器可以被加热或冷却到相应的不同温度 到相应PCR测试过程的不同热循环。
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公开(公告)号：US20060236766A1
公开(公告)日：2006-10-26
申请号：US11056130
申请日：2005-02-11
IPC分类号： G01H1/00
CPC分类号： G01F23/2962 , G01F23/2968 , G01N2035/0493 , G01N2035/1025 , G01N2291/02836 , G10K11/26
摘要： An ultrasonic beam shaping device includes a plate-like beam shaping element formed of opaque material. The beam shaping element has first and second conical surfaces, with a common axis, formed as opposite surface portions of the beam shaping element. A cylindrical aperture is formed in the beam shaping element along the common axis of the first and second conical surfaces such that the cylindrical aperture is also co-axial with the conical surfaces and passes through the conical surfaces. The beam shaping element thus has a circular open end at each conical surface.
摘要翻译： 超声波束整形装置包括由不透明材料形成的板状光束成形元件。 光束成形元件具有第一和第二锥形表面，共同的轴线形成为光束成形元件的相对表面部分。 沿着第一和第二锥形表面的公共轴线在梁成形元件中形成圆柱形孔，使得圆柱形孔也与锥形表面同轴并穿过锥形表面。 因此，光束成形元件在每个锥形表面具有圆形的开口端。
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9.发明授权Cup handling subsystem for an automated clinical chemistry analyzer system 失效用于自动化临床化学分析仪系统的杯子处理子系统公开(公告)号：US06881380B1
公开(公告)日：2005-04-19
申请号：US09626066
申请日：2000-07-26
CPC分类号： G01N35/04 , B65G59/062 , B65G59/105 , G01N2035/0427 , G01N2035/0465 , Y10T436/11 , Y10T436/113332
摘要： The present invention relates to a cup handling subsystem for an automated clinical chemistry analyzer system which includes a nestable sample cup for holding sample mixtures, a cup dispenser mechanism for holding and dispensing a supply of the cups into a sample shuttle for transporting them, and an incubator for controlling the temperature of the cup and its contents. In one embodiment, the cups include a conical lower portion and a cylindrical upper portion having a top flange, a bottom flange and a groove formed therebetween. An apparatus is provided for holding and dispensing a plurality of such cups including a supply tube for holding the cups in a stack wherein the stack has a bottom-most cup and a next-bottom-most cup located above the bottom-most cup. The apparatus also includes an escapement located at a lower end of the supply tube which includes a disk having an aperture formed therein, a first leaf attached to a top side of the disk and a second leaf attached to a bottom side of the disk. The disk is movable between a first position in which the second leaf engages the bottom flange of the bottom-most cup and a second position in which the first leaf is inserted into the groove of the next-bottom-most cup and engages the top flange of the next-bottom-most cup and in which the second leaf no longer engages the bottom flange of the bottom-most cup. In the second position, the bottom-most cup is free to fall through the aperture formed in the disk.
摘要翻译： 本发明涉及一种用于自动临床化学分析仪系统的杯子处理子系统，其包括用于保持样品混合物的可嵌套样品杯，用于保持和分配杯子供应到用于运输它们的样品梭中的杯分配器机构，以及 用于控制杯子及其内容物的温度的培养箱。 在一个实施例中，杯包括锥形下部和具有顶部凸缘，底部凸缘和在其间形成的凹槽的圆柱形上部。 提供了一种用于保持和分配多个这样的杯子的装置，其包括用于将杯子保持在堆叠中的供给管，其中所述烟囱具有最底部的杯子和位于最下面的杯子上方的下一个最下面的杯子。 该装置还包括位于供应管的下端处的擒纵机构，其包括具有形成在其中的孔的盘，附接到盘的顶侧的第一叶片和附接到盘的底侧的第二叶片。 盘可以在其中第二叶片接合最底部杯的底部凸缘的第一位置和第二位置之间移动，第二位置中第一叶片插入下一个最下面的杯子的凹槽中并且接合顶部凸缘 的下一个最下面的杯子，其中第二个叶子不再接合最底部的杯子的底部凸缘。 在第二位置，最下面的杯子可自由地落入通过形成在盘中的孔。
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公开(公告)号：US3970074A
公开(公告)日：1976-07-20
申请号：US499408
申请日：1974-08-22
申请人： Ion Mogos , Cornel Ionescu , Dionisie Angelescu , Nicolae Dumitrescu , Millo Andreescu , Constantin Neascu , Mircea Brozici , Mihai Birzanescu , Alexandru Puie , Gheorghe Vasilica
发明人： Ion Mogos , Cornel Ionescu , Dionisie Angelescu , Nicolae Dumitrescu , Millo Andreescu , Constantin Neascu , Mircea Brozici , Mihai Birzanescu , Alexandru Puie , Gheorghe Vasilica
CPC分类号： A61B5/01 , G01K1/026 , G01K13/002
摘要： An array of thermistors mounted on a resilient sponge are pressed against a body area to be examined such that each thermistor contacts a respective location on the body area. The outputs of the thermistors are fed to an electronic recording device (digital voltage recorder) which enters them on a chart so as to produce a visual representation illustrating the variations in temperature on the body area being examined.
摘要翻译： 安装在弹性海绵上的一组热敏电阻被压靠在要检查的身体区域上，使得每个热敏电阻接触身体区域上的相应位置。 热敏电阻的输出被馈送到电子记录装置（数字电压记录器），该电子记录装置在图表上进入它们，以产生示出正在检查的身体区域的温度变化的视觉表示。
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