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公开(公告)号：US20080132513A1
公开(公告)日：2008-06-05
申请号：US11861278
申请日：2007-09-25
申请人： Quinglin Che , Nha Huu Vo , Shoujun Chen
发明人： Quinglin Che , Nha Huu Vo , Shoujun Chen
IPC分类号： A61K31/498 , C07D513/04 , C07D417/02 , C07D239/70 , A61P37/06 , A61P29/00 , A61K31/435 , C07D487/00 , A61K31/429
CPC分类号： C07D513/04 , C07D277/60 , C07D401/04 , C07D403/04 , C07D417/04 , C07D417/14
摘要： The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些稠环化合物或其药学上可接受的盐，溶剂合物，包合物或前药。
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公开(公告)号：US20070244160A1
公开(公告)日：2007-10-18
申请号：US11758225
申请日：2007-06-05
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06384032B1
公开(公告)日：2002-05-07
申请号：US09594362
申请日：2000-06-15
申请人： Mitsunori Ono , Yumiko Wada , Beatrice Brunkhorst , Tadeusz Warchol , Wojciech Wrona , Dan Zhou , Nha Huu Vo , Stephen Gillies
发明人： Mitsunori Ono , Yumiko Wada , Beatrice Brunkhorst , Tadeusz Warchol , Wojciech Wrona , Dan Zhou , Nha Huu Vo , Stephen Gillies
IPC分类号： C07D25146
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).
摘要翻译： 本发明涉及可抑制IL-12产生的式（I）化合物。 还公开了通过向有需要的患者施用有效量的式（I）化合物来抑制IL-12产生的方法。
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公开(公告)号：US20110052643A1
公开(公告)日：2011-03-03
申请号：US12811402
申请日：2009-01-07
申请人： Qinglin Che , Nha Huu Vo , Shoujun Chen , Lijun Sun
发明人： Qinglin Che , Nha Huu Vo , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/56 , C07D333/80 , C07D409/10 , C07D277/60 , C07D221/16 , C07D401/10 , C07D241/54 , C07D223/24 , A61K31/381 , A61K31/4436 , A61K31/4178 , A61K31/428 , A61K31/435 , A61K31/498 , A61K31/55 , C12N5/078 , C12N5/071 , C12N5/0783 , C12N5/0781 , A61P29/00 , A61P19/02 , A61P19/08 , A61P11/06 , A61P17/06 , A61P17/00 , A61P25/16 , A61P37/06 , A61P9/10 , A61P35/00 , A61P3/00 , A61P25/00 , A61P25/28 , A61P37/08 , A61P43/00
CPC分类号： C07D333/80 , C07D209/70 , C07D221/06 , C07D277/60 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些稠环化合物或其药学上可接受的盐。
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公开(公告)号：US07414030B2
公开(公告)日：2008-08-19
申请号：US11029640
申请日：2005-01-05
申请人： Nha Huu Vo , Guoqiang Wang , Guoyou Xu , Ying Hou , Ying Sun , Ly Tam Phan , Zhe Wang , Yat Sun Or
发明人： Nha Huu Vo , Guoqiang Wang , Guoyou Xu , Ying Hou , Ying Sun , Ly Tam Phan , Zhe Wang , Yat Sun Or
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07273853B2
公开(公告)日：2007-09-25
申请号：US11042720
申请日：2005-01-25
申请人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07064110B2
公开(公告)日：2006-06-20
申请号：US10717290
申请日：2003-11-19
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US06720308B1
公开(公告)日：2004-04-13
申请号：US10289820
申请日：2002-11-07
申请人： Nha Huu Vo , Ying Hou , Ly Tam Phan , Yat Sun Or
发明人： Nha Huu Vo , Ying Hou , Ly Tam Phan , Yat Sun Or
IPC分类号： A01N4304
摘要： Novel 11-12 substituted lactone anhydrolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.
摘要翻译： 描述了含有治疗有效量的本发明化合物与药学上可接受的载体的组合的新颖的11-12取代的内酯无水物衍生物和药学上可接受的组合物。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。
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公开(公告)号：US08779154B2
公开(公告)日：2014-07-15
申请号：US11861278
申请日：2007-09-25
申请人： Qinglin Che , Nha Huu Vo , Shoujun Chen
发明人： Qinglin Che , Nha Huu Vo , Shoujun Chen
IPC分类号： A61K31/428 , A61K31/429 , C07D277/60 , C07D513/04
CPC分类号： C07D513/04 , C07D277/60 , C07D401/04 , C07D403/04 , C07D417/04 , C07D417/14
摘要： The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及可用作免疫抑制剂和用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些稠环化合物或其药学上可接受的盐，溶剂化物，包合物或前药。
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公开(公告)号：US20120035352A1
公开(公告)日：2012-02-09
申请号：US13185382
申请日：2011-07-18
申请人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Gouyou Xu
发明人： Yat Sun Or , Guoqiang Wang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Gouyou Xu
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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