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10 条记录 (耗时 0.037 秒)

    11-C-substituted erythromycin derivatives
    1.
    发明授权
    11-C-substituted erythromycin derivatives 有权
    11-C-取代的红霉素衍生物

    公开(公告)号：US06953782B2

    公开(公告)日：2005-10-11

    申请号：US10745856

    申请日：2003-12-24

    申请人： Ly Tam Phan ,  Yat Sun Or ,  Jay Judson Farmer

    发明人： Ly Tam Phan ,  Yat Sun Or ,  Jay Judson Farmer

    IPC分类号： A61K31/365 ,  A61K31/70 ,  A61K31/7048 ,  C07D313/00 ,  C07D313/06 ,  C07D313/20 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11-C-substituted derivatives of clarithromycin
    2.
    发明授权
    11-C-substituted derivatives of clarithromycin 失效
    克拉霉素的11-C-取代衍生物

    公开(公告)号：US06812216B2

    公开(公告)日：2004-11-02

    申请号：US10178991

    申请日：2002-06-25

    申请人： Ly Tam Phan ,  Jay Judson Farmer ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Jay Judson Farmer ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08 ,  A61K31/70

    摘要： There are described 11-C-substituted derivatives of clarithromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了克拉霉素的11-C-取代衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向动物施用含有治疗有效量的本发明化合物的药物组合物和这些化合物的制备方法来治疗细菌感染的方法。

    6,11-bicyclic erythromycin derivatives
    5.
    发明授权
    6,11-bicyclic erythromycin derivatives 有权
    6,11-双环红霉素衍生物

    公开(公告)号：US07129221B2

    公开(公告)日：2006-10-31

    申请号：US10436622

    申请日：2003-05-13

    申请人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Yao-Ling Qiu ,  Nha Huu Vo ,  Jay Judson Farmer ,  Ying Hou

    发明人： Yat Sun Or ,  Guoqiang Wang ,  Ly Tam Phan ,  Deqiang Niu ,  Yao-Ling Qiu ,  Nha Huu Vo ,  Jay Judson Farmer ,  Ying Hou

    IPC分类号： A61K31/7048 ,  A61K31/7052 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11-C-substituted ketolides
    7.
    发明授权
    11-C-substituted ketolides 失效
    11-C-取代的酮内酯

    公开(公告)号：US06750204B2

    公开(公告)日：2004-06-15

    申请号：US10179590

    申请日：2002-06-25

    申请人： Ly Tam Phan ,  Jay Judson Farmer ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Jay Judson Farmer ,  Yat Sun Or

    IPC分类号： A01N4304

    CPC分类号： C07H17/08

    摘要： There are described 11-C-substituted derivatives of erythromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了红霉素的11-C取代衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向动物施用含有治疗有效量的本发明化合物的药物组合物和这些化合物的制备方法来治疗细菌感染的方法。