公开(公告)号：US6156555A

公开(公告)日：2000-12-05

申请号：US172120

申请日：1998-10-14

Applicant: Toshii Iida ,  Toshihiko Kaminuma ,  Yuka Fuse ,  Masahiro Tajima ,  Mitsuo Yanagi ,  Hiroshi Okamoto ,  Jiro Kishimoto ,  Ohji Ifuku ,  Ichiro Kato

Inventor： Toshii Iida ,  Toshihiko Kaminuma ,  Yuka Fuse ,  Masahiro Tajima ,  Mitsuo Yanagi ,  Hiroshi Okamoto ,  Jiro Kishimoto ,  Ohji Ifuku ,  Ichiro Kato

IPC: C07K1/107 ,  C12N9/02 ,  C12N15/53 ,  C12N15/60 ,  C12N9/48 ,  C12N9/14 ,  C12N9/78 ,  C12N9/80 ,  C12N15/00

CPC classification number: C12N9/0071 ,  C07K1/107 ,  C12Y114/17003 ,  Y10S435/814 ,  Y10S435/815

Abstract: A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal .alpha.-hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of 25 to 40.degree. C. and a molecular weight of about 25 kDa or about 36 kDa, and metal ions and ascorbic acid act as a cofactor. A purified enzyme-II is obtained that participates in C-terminal amidation by acting on the peptide C-terminal .alpha.-hydroxyglycine adduct to produce a C-terminal amidated compound. The enzyme has an optimum pH of about 5 to 6, an optimum temperature of 15 to 35.degree. C. and a molecular weight of about 40 kDa or about 43 kDa. Enzyme-I does not act on the peptide C-terminal .alpha.-hydroxyglycine adduct and enzyme-II does not act on the peptide C-terminal glycine adduct. The enzymes may be purified from a biological material such as horse serum by affinity chromatography using a peptide C-terminal glycine adduct as a ligand. The enzymes may also be obtained from host cells transformed with a plasmid containing a cDNA coding for the enzymes. Assay of activity of the enzymes is carried out by measuring the C-terminal .alpha.-hydroxyglycine adduct or the C-terminal amidated compound that has been isolated such as by high performance liquid chromatography with the use of an acetonitrile-containing buffer.

Abstract translation: 获得通过作用于肽C-末端甘氨酸加合物以形成肽C末端α-羟基甘氨酸加合物参与C-末端酰胺化的纯化的酶I. 酶的最佳pH为约5至7，最适温度为25至40℃，分子量为约25kDa或约36kDa，金属离子和抗坏血酸用作辅因子。 获得了通过作用于肽C-末端α-羟基甘氨酸加合物参与C-末端酰胺化产生C末端酰胺化合物的纯化的酶-II。 酶的最佳pH为约5至6，最适温度为15至35℃，分子量为约40kDa或约43kDa。 酶-I不对肽C-端α-羟基甘氨酸加合物起作用，酶-II不对肽C-末端甘氨酸加合物起作用。 可以使用肽C-末端甘氨酸加合物作为配体通过亲和层析从生物材料如马血清中纯化酶。 酶也可以从用含有编码酶的cDNA的质粒转化的宿主细胞获得。 酶的活性测定是通过使用含有乙腈的缓冲液，通过高分辨液相色谱法测定已分离的C末端α-羟基甘氨酸加成物或C末端酰胺化合物进行的。

公开(公告)号：US5294550A

公开(公告)日：1994-03-15

申请号：US913884

申请日：1992-07-17

Applicant: Ken Kusakari ,  Mineyuki Yokoyama ,  Mitsuo Yanagi

Inventor： Ken Kusakari ,  Mineyuki Yokoyama ,  Mitsuo Yanagi

IPC: A01H4/00 ,  A01H5/02 ,  C12N5/04 ,  C12P19/44 ,  C12N5/00 ,  C12N5/02

CPC classification number: A01H4/00 ,  A01H5/02 ,  C12N5/04

Abstract: An improved process for the organ cultivation of a Mishima-saiko root is provided. In the cultivation of a Mishima-saiko root, by carrying out the cultivation while regulating the saccharide concentration to be less than 2%, until the adventitious roots have spread out, and optionally adding an additional saccharide, the productivity of saiko-saponin can be enhanced.

Abstract translation: 提供了改良三岛根的器官培养方法。 在三岛根的培养中，通过在调节糖浓度小于2％的同时进行培养，直到不定根扩散，并且任选地加入另外的糖，可以将saiko-saponin的生产率 增强。

公开(公告)号：US4556899A

公开(公告)日：1985-12-03

申请号：US386071

申请日：1982-06-07

Applicant: Yasutoshi Kurihara ,  Yoshihiro Suzuki ,  Michio Ooue ,  Hiroaki Hachino ,  Mitsuo Yanagi

Inventor： Yasutoshi Kurihara ,  Yoshihiro Suzuki ,  Michio Ooue ,  Hiroaki Hachino ,  Mitsuo Yanagi

IPC: H05K1/05 ,  H01L21/52 ,  H01L21/58 ,  H01L23/14 ,  H01L23/40 ,  H01L23/538 ,  H01L23/36 ,  H01L23/54

CPC classification number: H01L23/142 ,  H01L23/538 ,  H01L2224/48091 ,  H01L2224/48227 ,  H05K1/053

Abstract: In an insulated type semiconductor device, a metal member is disposed between an insulating member and a circuit element which includes a semiconductor substrate. The metal member is a composite metal member having at least two different kinds of metal layers bonded to each other. In a preferred embodiment, in order to reduce undesirable effects caused by differences in the thermal coefficients .alpha..sub.I and .alpha..sub.S of the insulating member and the semiconductor substrate, respectively, the thermal expansion coefficient of said composite metal member as a whole .alpha..sub.M is adjusted in a range between .alpha..sub.I and .alpha..sub.S.

Abstract translation: 在绝缘型半导体器件中，金属构件设置在绝缘构件和包括半导体衬底的电路元件之间。 金属构件是具有彼此结合的至少两种不同种类的金属层的复合金属构件。 在优选实施例中，为了减少由绝缘构件和半导体衬底的热系数α1和αS的差异引起的不期望的影响，调整整个αM的复合金属构件的热膨胀系数 在αI和αS之间的范围内。

公开(公告)号：US4542398A

公开(公告)日：1985-09-17

申请号：US621370

申请日：1984-06-18

Applicant: Tsutomu Yatsuo ,  Masayoshi Naito ,  Takahiro Nagano ,  Tomio Yasuda ,  Jin Onuki ,  Mitsuo Yanagi ,  Fumio Sato

Inventor： Tsutomu Yatsuo ,  Masayoshi Naito ,  Takahiro Nagano ,  Tomio Yasuda ,  Jin Onuki ,  Mitsuo Yanagi ,  Fumio Sato

IPC: H01L29/74 ,  H01L21/52 ,  H01L23/48 ,  H01L23/482 ,  H01L29/08 ,  H01L29/423 ,  H01L29/744

CPC classification number: H01L23/4824 ,  H01L24/72 ,  H01L29/0804 ,  H01L29/42304 ,  H01L29/42308 ,  H01L29/744 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01042 ,  H01L2924/01047 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/09701 ,  H01L2924/1301 ,  H01L2924/19043

Abstract: A multi-emitter type semiconductor device, namely, a semiconductor device having an arrangement in which a majority of emitter regions are divided by a gate region and surrounded thereby. In the semiconductor device, a member adapted to apply an external control signal to a gate electrode takes the form of a closed-loop shape and the majority of emitter regions are arranged on both sides of the loop. This arrangement ensures that the individual emitter regions, even when the number of the emitter regions is increased to a great extent, can be applied with a uniform control signal, thereby preventing degradation of the turn-off characteristics.

Abstract translation: 多射极型半导体器件，即具有这样一种布置的半导体器件，其中大部分发射极区域被栅极区域分开并被其包围。 在半导体器件中，适于向栅电极施加外部控制信号的部件采取闭环形状，并且大部分发射极区域布置在环路的两侧。 这种布置确保即使当发射极区域的数量增加到很大程度时，各个发射极区域也可以应用均匀的控制信号，从而防止关断特性的劣化。

公开(公告)号：US5871995A

公开(公告)日：1999-02-16

申请号：US070301

申请日：1991-05-24

Applicant: Toshii Iida ,  Toshihiko Kaminuma ,  Yuka Fuse ,  Masahiro Tajima ,  Mitsuo Yanagi ,  Hiroshi Okamoto ,  Jiro Kishimoto ,  Ohji Ifuku ,  Ichiro Kato

Inventor： Toshii Iida ,  Toshihiko Kaminuma ,  Yuka Fuse ,  Masahiro Tajima ,  Mitsuo Yanagi ,  Hiroshi Okamoto ,  Jiro Kishimoto ,  Ohji Ifuku ,  Ichiro Kato

IPC: C07K1/107 ,  C12N9/02 ,  C12N15/53 ,  C12N15/60 ,  C12N9/48 ,  C12N9/14 ,  C12N9/78 ,  C12N9/80

CPC classification number: C12N9/0071 ,  C07K1/107 ,  C12Y114/17003 ,  Y10S435/814 ,  Y10S435/815

Abstract: A purified enzyme-I is obtained that participates in C-terminal amidation by acting on a peptide C-terminal glycine adduct to form a peptide C-terminal .alpha.-hydroxyglycine adduct. The enzyme has an optimum pH of about 5 to 7, an optimum temperature of 25.degree. to 40.degree. C. and a molecular weight of about 25 kDa or about 36 kDa, and metal ions and ascorbic acid act as a cofactor. A purified enzyme-II is obtained that participates in C-terminal amidation by acting on a peptide C-terminal .alpha.-hydroxyglycine adduct to produce a C-terminal amidated compound. The enzyme has an optimum pH of about 5 to 6, an optimum temperature of 15.degree. to 35.degree. C. and a molecular weight of about 40 kDa or about 43 kDa. Enzyme-I does not act on the peptide C-terminal .alpha.-hydroxyglycine adduct and enzyme-II does not act on the peptide C-terminal glycine adduct. The enzymes may be purified from a biological material such as horse serum by affinity chromatography using a peptide C-terminal glycine adduct as a ligand. The enzymes may also be obtained from host cells transformed with a plasmid containing a cDNA coding for the enzymes. Assay of activity of the enzymes is carried out by measuring adduct (II) or the compound (III) that has been isolated such as by high performance liquid chromatography with the use of an acetonitrile-containing buffer.

Abstract translation: PCT No.PCT / JP90 / 01036 Sec。 371日期1991年5月24日 102（e）日期1991年5月24日PCT提交1990年4月12日PCT公布。 公开号WO91 / 02790 日期1991年3月7日获得通过作用于肽C-末端甘氨酸加合物以形成肽C-末端α-羟基甘氨酸加合物参与C-末端酰胺化的纯化的酶-I。 酶的最佳pH为约5至7，最适温度为25至40℃，分子量为约25kDa或约36kDa，金属离子和抗坏血酸用作辅因子。 获得了通过作用于肽C-末端α-羟基甘氨酸加合物以产生C末端酰胺化合物而参与C-末端酰胺化的纯化的酶-II。 酶的最佳pH为约5至6，最适温度为15-35℃，分子量为约40kDa或约43kDa。 酶-I不对肽C-端α-羟基甘氨酸加合物起作用，酶-II不对肽C-末端甘氨酸加合物起作用。 可以使用肽C-末端甘氨酸加合物作为配体通过亲和层析从生物材料如马血清中纯化酶。 酶也可以从用含有编码酶的cDNA的质粒转化的宿主细胞获得。 酶的活性测定是通过使用含乙腈的缓冲液测定加成物（II）或分离的化合物（III），例如通过高效液相色谱法进行的。

公开(公告)号：US5682466A

公开(公告)日：1997-10-28

申请号：US117765

申请日：1993-09-08

Applicant: Akira Maeda ,  Motohisa Funabashi ,  Hiromasa Yamaoka ,  Nobuyuki Fujikura ,  Mikio Yoda ,  Mitsuo Yanagi

Inventor： Akira Maeda ,  Motohisa Funabashi ,  Hiromasa Yamaoka ,  Nobuyuki Fujikura ,  Mikio Yoda ,  Mitsuo Yanagi

IPC: G05B13/02 ,  G06K9/64 ,  G06F17/00

CPC classification number: G05B13/0275 ,  G06K9/64 ,  Y10S706/903

Abstract: An information processing apparatus, which is easy to design and has functions of high speed processing, learning, and so on, includes a plurality of memories for storing sets of previously known input data (called response pattern data) and correct output data corresponding thereto; a comparator for providing input data supplied in actual operations to the plurality of sets and comparing the input data with the response pattern data in each set; an evaluation unit for evaluating the distance (degree of similarity) between the input data and the response pattern data; and a generator for generating final outputs by composing the evaluation result for each set and the output data in that set, for example, using a method which calculates weighted average values based on the evaluated distances.

Abstract translation: 易于设计并具有高速处理，学习等功能的信息处理装置包括多个存储器，用于存储先前已知的输入数据（称为响应模式数据）和正确的对应的输出数据的集合; 比较器，用于将实际操作中提供的输入数据提供给多个组，并将输入数据与每组中的响应模式数据进行比较; 评估单元，用于评估输入数据和响应模式数据之间的距离（相似度）; 以及发生器，用于通过组合各组的评估结果和该组中的输出数据来生成最终输出，例如使用基于评估的距离来计算加权平均值的方法。

公开(公告)号：US5354675A

公开(公告)日：1994-10-11

申请号：US459829

申请日：1990-01-29

Applicant: Toshii Iida ,  Yuka Fuse ,  Masahiro Tajima ,  Mitsuo Yanagi ,  Hiroshi Okamoto

Inventor： Toshii Iida ,  Yuka Fuse ,  Masahiro Tajima ,  Mitsuo Yanagi ,  Hiroshi Okamoto

IPC: C07K1/107 ,  C12N9/02 ,  C12P21/00 ,  C12N9/00

CPC classification number: C12N9/0071 ,  C07K1/107 ,  C12Y114/17003

Abstract: A C-terminal amidating enzyme composition is disclosed having the ability to amidate the C-terminus of peptides with a C-terminal glycine. The C-terminal amidating enzyme is characterized by having a stable pH range of 5 to 9, metal ions and L-ascorbic acid as cofactors, two active fractions at molecular weights of about 50,000 and about 100,000 as determined from gel filtration, isoelectric points of about 4.5 pH for the active fraction having a molecular weight of about 50,000 and about 6.7 pH for the active fraction having a molecular weight of about 100,000 according to isoelectric point chromatography, and is activated by addition of catalase.

Abstract translation: PCT No.PCT / JP89 / 00521 Sec。 371 1990年1月29日第 102（e）日期1990年1月29日PCT提交1989年5月25日PCT公布。 出版物WO89 / 12096 公开了C端氨酰化酶组合物，其具有用C-末端甘氨酸酰胺化肽​​的C末端的能力。 C末端酰胺化酶的特征在于具有5至9的稳定的pH范围，金属离子和L-抗坏血酸作为辅因子，分子量约50,000和约100,000的活性级分由凝胶过滤确定，等电点 根据等电点色谱法，对于分子量约为50,000的活性级分，对于分子量为约50,000的活性级分和约6.7pH的活性级分为大约4.5的pH，并且通过加入过氧化氢酶来活化。

公开(公告)号：US5638492A

公开(公告)日：1997-06-10

申请号：US291869

申请日：1994-08-17

Applicant: Akira Maeda ,  Motohisa Funabashi ,  Hiromasa Yamaoka ,  Nobuyuki Fujikura ,  Mikio Yoda ,  Mitsuo Yanagi ,  Toshihide Ichimori

Inventor： Akira Maeda ,  Motohisa Funabashi ,  Hiromasa Yamaoka ,  Nobuyuki Fujikura ,  Mikio Yoda ,  Mitsuo Yanagi ,  Toshihide Ichimori

IPC: G05B13/02 ,  G06K9/64 ,  G06F17/00

CPC classification number: G06K9/64 ,  G05B13/0285 ,  F02D41/1405 ,  Y10S706/903

Abstract: An information processing apparatus is capable of achieving high-level functions such as high-speed processing and learning without requiring a complex algorithm based on, for example, knowledge processing. A plurality of sets of known input data and correct output data corresponding thereto are beforehand stored. The stored input data is called response pattern data. Data actually inputted in the system operation is supplied to the plural sets of data. For each set of data, the input data is compared with the response pattern data to evaluate a distance (degree of similarity) therebetween. Results of evaluations for the respective sets of data are combined with the associated output data, for example, according to weighted average values on the basis of the evaluated distance, thereby generating final outputs.

Abstract translation: 信息处理装置能够实现诸如高速处理和学习的高级功能，而不需要基于例如知识处理的复杂算法。 预先存储多组已知的输入数据和与之对应的正确的输出数据。 存储的输入数据称为响应模式数据。 在系统操作中实际输入的数据被提供给多组数据。 对于每组数据，将输入数据与响应模式数据进行比较，以评估它们之间的距离（相似度）。 将各组数据的评估结果与相关的输出数据组合，例如根据所评估距离的加权平均值，从而产生最终输出。

公开(公告)号：US4728667A

公开(公告)日：1988-03-01

申请号：US858471

申请日：1986-04-30

Applicant: Mitsuo Yanagi ,  Masataka Ogawa ,  Uhei Tamura ,  Tetsuo Sakamoto

Inventor： Mitsuo Yanagi ,  Masataka Ogawa ,  Uhei Tamura ,  Tetsuo Sakamoto

IPC: A61K8/42 ,  A61K8/67 ,  A61K31/165 ,  A61K31/355 ,  A61Q5/00 ,  A61K31/17

CPC classification number: A61Q5/006 ,  A61K8/42 ,  A61K8/678 ,  Y10S424/04 ,  Y10S514/852 ,  Y10S514/88 ,  Y10S514/881

Abstract: A hair treatment composition comprising 0.1% by weight or more of 3,4,4'-trichlorocarbanilide and 0.03% by weight or more of vitamine E acetate in an aqueous medium.This hair treatment composition can effectively prevent dandruff in the hair without causing adverse side effects to the skin or scalp.

Abstract translation: 包含0.1重量％以上的3,4,4'-三氯碳酰苯胺和0.03重量％以上的维生素E乙酸酯在水性介质中的护发组合物。 这种头发处理组合物可以有效地防止毛发中的头皮屑，而不会对皮肤或头皮造成不利的副作用。

公开(公告)号：US3976789A

公开(公告)日：1976-08-24

申请号：US438525

申请日：1974-02-01

Applicant: Kenichi Tomita ,  Mitsuo Yanagi ,  Toshiaki Kobayashi

Inventor： Kenichi Tomita ,  Mitsuo Yanagi ,  Toshiaki Kobayashi

IPC: A61K8/37 ,  A61Q1/06 ,  A61Q19/00 ,  A61Q19/10 ,  A61K47/00

CPC classification number: A61Q19/00 ,  A61K8/375 ,  A61K2800/75 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q19/10 ,  A61Q5/06

Abstract: A cosmetic composition comprising at least one compound selected from the group consisting of saturated triesters and tetraesters having a side chain at the 2-position and having the general formulaR(OCOR').sub.nwherein R is an alkyl group of trimethylolethane, trimethylolpropane or pentaerythritol, R' is an alkyl group of 2-ethylhexanoic acid, 2-hexyl-decanoic acid or 2-hepty-undecanoic acid, and n is an integer of 3 and 4.

Abstract translation: 一种化妆品组合物，其包含至少一种选自饱和三酯和具有2位侧链的四酯的化合物，并具有通式R（OCOR'）n WHEREIN R是三羟甲基乙烷的烷基，三羟甲基丙烷或季戊四醇 R'是2-乙基己酸，2-己基癸酸或2-庚基十一烷酸的烷基，n是3和4的整数。