公开(公告)号：US20080138611A1

公开(公告)日：2008-06-12

申请号：US11722054

申请日：2005-12-16

申请人： Mikito Yasuzawa ,  Takashi Koide

发明人： Mikito Yasuzawa ,  Takashi Koide

IPC分类号： B32B9/04 ,  B05D1/36

CPC分类号： C23C18/1225 ,  B05D7/51 ,  C09D183/16 ,  C23C18/122 ,  Y10T428/26 ,  Y10T428/265

摘要： A method for modifying the surface of a substrate includes the following steps: (1) a step for forming a polysilazane coating by applying a polysilazane onto the surface of a substrate; (2) a step for applying an organic compound of which main backbone comprises an organic group represented by the following formula [1]: —[(R)mO]n— (wherein R represents an alkylene group, and m and n respectively represent a positive number of not less than 1) onto the surface of the polysilazane coating; and (3) a step for heating the substrate having undergone the steps (1) and (2), thereby converting the polysilazane to silica and bonding the organic compound to the silica of the silica layer.

摘要翻译： 改性基材表面的方法包括以下步骤：（1）通过将聚硅氮烷涂覆在基材的表面上形成聚硅氮烷涂层的步骤; （2）主要骨架包含由下式[1]表示的有机基团的有机化合物的步骤： - [（R）m O] n < - （其中R表示亚烷基，m和n分别表示不小于1的正数）到聚硅氮烷涂层的表面上; 和（3）加热步骤（1）和（2）的基板的步骤，从而将聚硅氮烷转化为二氧化硅并将有机化合物粘合到二氧化硅层的二氧化硅上。

公开(公告)号：US20070088208A1

公开(公告)日：2007-04-19

申请号：US10544243

申请日：2004-02-16

申请人： Mikito Yasuzawa ,  Shinji Imai

发明人： Mikito Yasuzawa ,  Shinji Imai

IPC分类号： A61B5/05 ,  A61N1/00 ,  A61B5/04 ,  A61N1/04 ,  G01N27/30

CPC分类号： A61B5/04001 ,  A61B2562/0215 ,  A61N1/05

摘要： The object of the present invention is to provide a linear device which is very thin, can be inserted into a desired region of a subject, and minimizes the damage to the subject. The linear device is a linear member, which comprises a base layer extending in the axial directions of the linear member and a plurality of layers formed on the base layer and extending in the axial directions of the linear member. Two or more of said plurality of layers are conductive layers and two or more of said plurality of layers are insulating layers. Each insulating layer is disposed between the conductive layers. When the linear device is embedded in or its front end is inserted into a region of a subject, electric stimuli can be given to the region and the electric resistance of the region can be measured. Because the linear device is very thin, pain or uncomfortable feeling at the region is slight when it is inserted or embedded in a region of the human body or the like.

摘要翻译： 本发明的目的是提供一种非常薄的线性装置，其可被插入到受试者的期望区域中，并且使对受试者的损害最小化。 线性装置是线性构件，其包括在线性构件的轴向方向上延伸的基底层和形成在基底层上并在线性构件的轴向方向上延伸的多个层。 所述多个层中的两个或多个是导电层，并且所述多个层中的两个或更多个层是绝缘层。 每个绝缘层设置在导电层之间。 当将线性装置嵌入或将其前端插入到受试者的区域中时，可以对该区域施加电刺激，并且可以测量该区域的电阻。 由于线性装置非常薄，所以在插入或嵌入人体等的区域时，该区域的疼痛或不舒适的感觉是轻微的。

公开(公告)号：US08364233B2

公开(公告)日：2013-01-29

申请号：US12278829

申请日：2007-02-08

申请人： Mikito Yasuzawa ,  Shinya Furukawa

发明人： Mikito Yasuzawa ,  Shinya Furukawa

IPC分类号： A61B5/04 ,  C12M1/34

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/150977 ,  A61B5/151 ,  A61B5/685 ,  Y10T436/104998

摘要： A biodevice is in an elongated form and has a conductive layer and an insulating layer stacked on a side surface of a shaft member at the center. A cylindrical hollow section is formed through the device, being connected to the exterior at a front end and extending from this front end axially. An electrode section is formed on an inner surface. A sensing substance such as enzyme may be placed at the electrode section to detect a current value corresponding to the concentration or quantity of an object under test placed between a counter electrode and the biodevice.

摘要翻译： 生物器件是细长的形式，并且在中心处具有层叠在轴构件的侧表面上的导电层和绝缘层。 通过该装置形成圆柱形的中空部分，其在前端处连接到外部并且从该前端轴向延伸。 电极部分形成在内表面上。 诸如酶的感测物质可以放置在电极部分处，以检测对应于放置在对电极和生物器件之间的被测物体的浓度或数量的电流值。

公开(公告)号：US08277929B2

公开(公告)日：2012-10-02

申请号：US11722054

申请日：2005-12-16

申请人： Mikito Yasuzawa ,  Takashi Koide

发明人： Mikito Yasuzawa ,  Takashi Koide

IPC分类号： B32B27/32 ,  B32B9/04 ,  B05D1/40 ,  B05D3/02

CPC分类号： C23C18/1225 ,  B05D7/51 ,  C09D183/16 ,  C23C18/122 ,  Y10T428/26 ,  Y10T428/265

摘要： A method for modifying the surface of a substrate includes the following steps: (1) a step for forming a polysilazane coating by applying a polysilazane onto the surface of a substrate; (2) a step for applying an organic compound of which main backbone comprises an organic group represented by the following formula [1]: —[(R)mO]n— (wherein R represents an alkylene group, and m and n respectively represent a positive number of not less than 1) onto the surface of the polysilazane coating; and (3) a step for heating the substrate having undergone the steps (1) and (2), thereby converting the polysilazane to silica and bonding the organic compound to the silica of the silica layer.

摘要翻译： 改性基材表面的方法包括以下步骤：（1）通过将聚硅氮烷涂覆在基材的表面上形成聚硅氮烷涂层的步骤; （2）主骨架包含由下式[1]表示的有机基团的有机化合物的步骤： - [（R）mO] n - （其中R表示亚烷基，m和n分别表示 正数不少于1）在聚硅氮烷涂层的表面上; 和（3）加热步骤（1）和（2）的基板的步骤，从而将聚硅氮烷转化为二氧化硅并将有机化合物粘合到二氧化硅层的二氧化硅上。

公开(公告)号：US20090069654A1

公开(公告)日：2009-03-12

申请号：US12278829

申请日：2007-02-08

申请人： Mikito Yasuzawa ,  Shinya Furukawa

发明人： Mikito Yasuzawa ,  Shinya Furukawa

IPC分类号： A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/150977 ,  A61B5/151 ,  A61B5/685 ,  Y10T436/104998

摘要： A biodevice is in an elongated form and has a conductive layer and an insulating layer stacked on a side surface of a shaft member at the center. A cylindrical hollow section is formed through the device, being connected to the exterior at a front end and extending from this front end axially. An electrode section is formed on an inner surface. A sensing substance such as enzyme may be placed at the electrode section to detect a current value corresponding to the concentration or quantity of an object under test placed between a counter electrode and the biodevice.

摘要翻译： 生物器件是细长的形式，并且在中心处具有层叠在轴构件的侧表面上的导电层和绝缘层。 通过该装置形成圆柱形的中空部分，其在前端处连接到外部并且从该前端轴向延伸。 电极部分形成在内表面上。 诸如酶的感测物质可以放置在电极部分处，以检测对应于放置在对电极和生物器件之间的被测物体的浓度或数量的电流值。