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公开(公告)号：USRE42376E1
公开(公告)日：2011-05-17
申请号：US12785269
申请日：2010-05-21
Applicant: Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
Inventor： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Philip Frost
IPC: A61K31/47 , C07D215/44
CPC classification number: C07D215/54 , C07D215/44 , C07D215/56
Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
Abstract translation: 本发明提供具有以下结构的式I化合物：其中G1，G2，R1，R4，Z，n和X在本说明书中定义，或其药学上可接受的盐，其可用作抗肿瘤剂和治疗多囊肾病 。
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2.发明授权Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones 失效新型2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代环戊烯酮
公开(公告)号：US4737590A
公开(公告)日：1988-04-12
申请号：US268178
申请日：1981-05-29
Applicant: Middleton B. Floyd, Jr.
Inventor： Middleton B. Floyd, Jr.
IPC: C07C29/42 , C07C43/12 , C07C43/166 , C07C43/176 , C07C45/00 , C07C51/09 , C07C51/363 , C07C51/367 , C07C53/19 , C07C53/42 , C07C59/01 , C07C405/00 , C07D307/935 , C07D309/12 , C07F1/02 , C07F3/02 , C07F7/08 , C07F7/18
CPC classification number: C07D307/935 , C07C29/42 , C07C405/00 , C07C43/12 , C07C43/166 , C07C43/176 , C07C45/00 , C07C51/09 , C07C51/363 , C07C51/367 , C07C53/19 , C07C53/42 , C07C59/01 , C07D309/12 , C07F1/02 , C07F3/02 , C07F7/1896 , C07B2200/09
Abstract: This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.
Abstract translation: 本公开描述了可用作制备E2，E3和F系列的同型或非前列腺素的中间体的新型4-氧-2-取代 - 环戊-2-烯-1-酮。
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公开(公告)号：US4536517A
公开(公告)日：1985-08-20
申请号：US488237
申请日：1983-04-25
Applicant: Middleton B. Floyd, Jr. , Jo A. Goidl
Inventor： Middleton B. Floyd, Jr. , Jo A. Goidl
IPC: A61K31/12 , A61K31/135 , A61K31/185 , A61K31/19 , A61K31/34 , A61K31/38 , C07C45/28 , C07C45/46 , C07C45/64 , C07C45/71 , C07C49/782 , C07C49/807 , C07C49/813 , C07C49/82 , C07C49/83 , C07C49/84 , C07C49/86 , C07D307/91 , C07D333/22 , C07D333/76
CPC classification number: C07D307/91 , A61K31/12 , A61K31/135 , A61K31/185 , A61K31/19 , A61K31/34 , A61K31/38 , C07C309/00 , C07C45/28 , C07C45/46 , C07C45/64 , C07C45/71 , C07C49/782 , C07C49/807 , C07C49/813 , C07C49/82 , C07C49/83 , C07C49/84 , C07C49/86 , C07D333/22 , C07D333/76 , Y10S514/866
Abstract: A method of treating diabetes mellitus using arylglyoxals which are known compounds.
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4.发明授权Novel hydroxy substituted prostanoic acids, esters, congeners, intermediates and process 失效新型羟基取代的前列腺酸，酯，同系物，中间体和方法
公开(公告)号：US4439365A
公开(公告)日：1984-03-27
申请号：US58415
申请日：1979-07-18
Applicant: Middleton B. Floyd, Jr. , Martin J. Weiss , John F. Poletto , Robert E. Schaub , Karel F. Bernady
Inventor： Middleton B. Floyd, Jr. , Martin J. Weiss , John F. Poletto , Robert E. Schaub , Karel F. Bernady
IPC: C07C29/143 , C07C29/42 , C07C43/12 , C07C45/00 , C07C45/63 , C07C51/60 , C07C405/00 , C07D303/38 , C07D307/935 , C07D309/12 , C07F1/00 , C07F5/06 , C07F9/54 , C09B11/06
CPC classification number: C07D303/38 , C07C29/143 , C07C29/42 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07C405/0033 , C07C43/12 , C07C51/60 , C07D307/935 , C07D309/12 , C07F1/00 , C07F5/062 , C07F9/5407 , C07B2200/09
Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.
Abstract translation: 本公开描述了可用作支气管扩张剂，抗溃疡剂或作为中间体的某些11-羟基和11-脱氧-9-酮（或羟基） - 前列环酸衍生物。
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5.发明授权
公开(公告)号：US4291175A
公开(公告)日：1981-09-22
申请号：US137082
申请日：1980-04-03
Applicant: Allan Wissner , Middleton B. Floyd, Jr.
Inventor： Allan Wissner , Middleton B. Floyd, Jr.
IPC: C07C45/59 , C07C59/245 , C07C405/00 , C07D307/32 , C07D307/42 , C07D307/46 , C07D317/16 , C07D317/24 , C07D317/34 , C07F7/18 , C07F9/54 , C07C35/06 , C07C49/597 , C07C49/798
CPC classification number: C07D307/32 , C07C405/0016 , C07C405/0025 , C07C45/59 , C07C59/245 , C07D307/42 , C07D307/46 , C07D317/16 , C07D317/24 , C07D317/34 , C07F7/1856 , C07F9/5407 , Y10S514/822 , Y10S514/929
Abstract: Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
Abstract translation: 公开前列腺素类似物，其具有以基团-CH（OR'）OR“终止的α-链，其中R'和R”相同或不同，并且是氢，C 1至C 4烷酰基或任选取代的苯甲酰基，取代基 选自C1至C4烷基，C1至C4烷氧基，卤素和三氟甲基。 这些化合物可用作降压药，胃分泌和血小板聚集抑制剂和支气管扩张剂。
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Patent Agency Ranking
公开(公告)号：US4288630A
公开(公告)日：1981-09-08
申请号：US137084
申请日：1980-04-03
Applicant: Allan Wissner , Middleton B. Floyd, Jr.
Inventor： Allan Wissner , Middleton B. Floyd, Jr.
IPC: C07C45/59 , C07C49/743 , C07C59/245 , C07C405/00 , C07D307/42 , C07D307/54 , C07D307/60 , C07D317/16 , C07D317/18 , C07D317/34 , C07F7/18 , C07F9/54 , C07C49/597 , C07C35/06 , C07C49/798
CPC classification number: C07D307/42 , C07C405/0016 , C07C405/0025 , C07C45/59 , C07C49/743 , C07C59/245 , C07D307/54 , C07D307/60 , C07D317/16 , C07D317/18 , C07D317/34 , C07F7/1856 , C07F9/5407
Abstract: Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.
Abstract translation: 公开前列腺素类似物，其具有以基团-CH（OR'）OR“终止的α-链，其中R'和R”相同或不同，并且是氢，C 1至C 4烷酰基或任选取代的苯甲酰基，取代基 选自C1至C4烷基，C1至C4烷氧基，卤素和三氟甲基。 这些化合物可用作降压药，胃分泌和血小板聚集抑制剂和支气管扩张剂。
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公开(公告)号：US4260805A
公开(公告)日：1981-04-07
申请号：US79621
申请日：1979-09-27
Applicant: Middleton B. Floyd, Jr.
Inventor： Middleton B. Floyd, Jr.
IPC: C07C405/00 , C07D307/32 , C07F7/18 , C07C177/00
CPC classification number: C07D307/32 , C07C243/00 , C07C405/00 , C07F7/1856
Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
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公开(公告)号：US4250321A
公开(公告)日：1981-02-10
申请号：US79634
申请日：1979-09-27
Applicant: Middleton B. Floyd, Jr.
Inventor： Middleton B. Floyd, Jr.
IPC: C07C405/00 , C07D307/54 , C07F7/18 , C07C177/00
CPC classification number: C07C251/72 , C07C243/00 , C07C405/00 , C07D307/54 , C07F7/1856
Abstract: This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
Abstract translation: 本公开内容描述了可用作支气管扩张剂，降血压药，抗溃疡剂或中间体的某些11-羟基和11-脱氧-1-酮羧酸前列腺酸及其衍生物。
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公开(公告)号：US4239900A
公开(公告)日：1980-12-16
申请号：US74942
申请日：1979-09-13
Applicant: Middleton B. Floyd, Jr. , Martin J. Weiss , Charles V. Grudzinskas , Sow-Mei L. Chen
Inventor： Middleton B. Floyd, Jr. , Martin J. Weiss , Charles V. Grudzinskas , Sow-Mei L. Chen
IPC: C07C29/10 , C07C29/42 , C07C405/00 , C07D307/42 , C07F7/08 , C07F7/18 , C07F7/22 , C07C177/00
CPC classification number: C07D307/42 , C07C29/10 , C07C29/42 , C07C405/00 , C07F7/0818 , C07F7/1864 , C07F7/1896 , C07F7/2212 , C07B2200/07 , C07C2101/10
Abstract: 15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents, and as agents for the control of excessive gastric secretion.
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10.发明授权Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones 失效新型2-取代-3,4-环氧环戊烷-1-酮，2-取代-3,4-环氧环戊烷-1-醇和各种2-取代环戊烯酮
公开(公告)号：US4237316A
公开(公告)日：1980-12-02
申请号：US616790
申请日：1975-09-25
Applicant: Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
Inventor： Karel F. Bernady , Middleton B. Floyd, Jr. , John F. Poletto , Robert E. Schaub , Martin J. Weiss
IPC: C07C33/42 , C07C43/166 , C07C43/176 , C07C51/09 , C07C51/363 , C07C51/367 , C07C405/00 , C07D309/12 , C07F7/18 , C07C51/353
CPC classification number: C07F7/1896 , C07C33/423 , C07C405/00 , C07C43/166 , C07C43/176 , C07C51/09 , C07C51/363 , C07C51/367 , C07D309/12
Abstract: This disclosure describes novel 4-oxy-2-substituted-cyclopent-2-en-1-ones useful as intermediates for the preparation of homo and nor prostaglandins of the E.sub.2, E.sub.3 and F series.
Abstract translation: 本公开描述了可用作制备E2，E3和F系列的同型或非前列腺素的中间体的新型4-氧-2-取代 - 环戊-2-烯-1-酮。
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