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公开(公告)号：US5571790A
公开(公告)日：1996-11-05
申请号：US472964
申请日：1995-06-07
Applicant: Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
Inventor： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC classification number: C07K14/501 , A61K38/00 , Y10S930/12
Abstract: Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-lined structures.
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2.发明申请LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies 有权三酰基甘油脂肪酶家族的LLG多肽及其用于酶水解的组合物和方法以及蛋白质和基因治疗公开(公告)号：US20070101451A1
公开(公告)日：2007-05-03
申请号：US11369410
申请日：2006-03-07
Applicant: Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South
Inventor： Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South
IPC: A01K67/027 , C07H21/02 , C12P21/06 , A61K38/46 , A61K39/395 , C12N9/20
CPC classification number: C07K16/40 , A01K2217/05 , A61K38/00 , C12N9/18 , C12N9/20
Abstract: Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of said polypeptides to screen for agonists and or antagonists of said polypeptides. Also disclosed are methods and compositions for the treatment of disorders of lipid metabolism.
Abstract translation: 公开了脂蛋白脂肪酶样多肽，编码所述多肽的核酸，反义序列和针对所述多肽的抗体。 还公开了在重组系统中制备所述多肽的方法，以及所述多肽用于筛选所述多肽的激动剂和/或拮抗剂的方法。 还公开了用于治疗脂质代谢紊乱的方法和组合物。
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3.发明申请Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein Al, very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol 审中-公开用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白A1，极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US20060088504A1
公开(公告)日：2006-04-27
申请号：US11254195
申请日：2005-10-19
Applicant: Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South , Dawn Marchadier , Cyrille Maugeais , Daniel Rader
Inventor： Michael Jaye , Kim-Anh Doan , John Krawiec , Kevin Lynch , Dilip Amin , Victoria South , Dawn Marchadier , Cyrille Maugeais , Daniel Rader
CPC classification number: G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
Abstract: Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
Abstract translation: 用于提高患者中HDL胆固醇和载脂蛋白AI水平以及降低患者中VLDL胆固醇和LDL胆固醇水平的组合物和方法，包括影响基因表达的组合物和方法，LIPG编码脂肪酶 其是三酰基甘油脂肪酶家族的成员或其影响酶的酶活性。
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4.发明申请Compositions and Methods for Effecting the Levels of High Density Lipoprotein (HDL) Cholesterol and Apolipoprotein AI, Very Low Density Lipoprotein (VLDL) Cholesterol and Low Density Lipoprotein (LDL) Cholesterol 审中-公开用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白AI，极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US20090208479A1
公开(公告)日：2009-08-20
申请号：US12197970
申请日：2008-08-25
Applicant: Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
Inventor： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
CPC classification number: G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
Abstract: Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
Abstract translation: 用于提高患者中HDL胆固醇和载脂蛋白AI水平以及降低患者中VLDL胆固醇和LDL胆固醇水平的组合物和方法，包括影响基因表达的组合物和方法，LIPG编码脂肪酶 其是三酰基甘油脂肪酶家族的成员或其影响酶的酶活性。
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5.发明授权DNA encoding human endothelial cell growth factors and plasmids comprising said DNA 失效编码人内皮细胞生长因子的DNA和包含所述DNA的质粒
公开(公告)号：US5849538A
公开(公告)日：1998-12-15
申请号：US840088
申请日：1997-04-11
Applicant: Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
Inventor： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC classification number: C07K14/501 , A61K38/00 , Y10S930/12
Abstract: The present invention is directed to DNA encoding human endothelial cell growth factors, and to plasmids comprising said DNA. In particular, the invention relates to DNA encoding a cleavable signal peptide and an endothelial cell growth factor, wherein removal of said signal peptide yields a mature form of the growth factor.
Abstract translation: 本发明涉及编码人内皮细胞生长因子的DNA和包含所述DNA的质粒。 特别地，本发明涉及编码可切割信号肽和内皮细胞生长因子的DNA，其中所述信号肽的去除产生成熟形式的生长因子。
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Patent Agency Ranking
公开(公告)号：US4868113A
公开(公告)日：1989-09-19
申请号：US835594
申请日：1986-03-03
Applicant: Michael Jaye , Wilson Burgess , Thomas Maciag , William Drohan
Inventor： Michael Jaye , Wilson Burgess , Thomas Maciag , William Drohan
IPC: C12N15/09 , A61K38/00 , A61K38/27 , A61P17/00 , A61P43/00 , C07H21/04 , C07K14/00 , C07K14/50 , C07K14/52 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/10 , C12N15/18 , C12N15/24 , C12N15/74 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/91
CPC classification number: C07K14/501 , A61K38/00 , Y10S930/12
Abstract: Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering ECGF protein essentially free of other proteins of human origin. The product is useful for, among other purposes, diagnostic applications and as potential in the treatment of damaged blood vessels or other endothelial cell-line structures.
Abstract translation: 内皮细胞生长因子通过应用重组DNA技术来制备编码ECGF蛋白质的克隆载体，公开了用于回收基本上不含人源蛋白质的ECGF蛋白质的方法。 该产品除了其它目的之外可用于诊断应用，并且用于治疗损伤的血管或其它内皮细胞系结构的潜力。
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公开(公告)号：US06635197B2
公开(公告)日：2003-10-21
申请号：US09891117
申请日：2001-06-25
Applicant: John David Cortum , Michael Jaye Mathiasmeier , Louis William Stoecker
Inventor： John David Cortum , Michael Jaye Mathiasmeier , Louis William Stoecker
IPC: B29C3106
CPC classification number: C06B21/005 , F42B33/0214 , Y10S425/245
Abstract: A method and apparatus for casting a molten material using a phase-change material. A funnel means is provided that includes a reservoir containing a phase-change material. The funnel means is used in conjunction with a mold. The phase-change material is heated to a temperature above its melting point. A molten material is poured into the mold, and an excess amount of the molten material is retained in the funnel means after the mold is filled. The latent heat of fusion of the phase-change material provides heat to the funnel means as the phase-change material changes from a liquid to a solid. The heat from the phase-change material maintains the temperature of the molten material within the funnel above its melting point as the molten material within the mold begins to solidify and contract, thereby permitting the excess material within the funnel means to feed into the mold and fill any voids or porosities formed by the contraction of the material within the mold. The funnel means may also include a neck-engaging portion in thermal contact with the phase-change material for engaging an upper, or neck, portion of the mold to maintain molten material contained within that portion above its melting temperature for an extended period of time. The apparatus and method are particularly well suited for use in casting explosive projectile shells.
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公开(公告)号：US20130059361A1
公开(公告)日：2013-03-07
申请号：US13323731
申请日：2011-12-12
Applicant: Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
Inventor： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
CPC classification number: G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
Abstract: Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a member of the triacylglycerol lipase family or which effect the enzymatic activity of the enzyme.
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9.发明授权Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol 失效用于影响高密度脂蛋白（HDL）胆固醇和载脂蛋白AI极低密度脂蛋白（VLDL）胆固醇和低密度脂蛋白（LDL）胆固醇水平的组合物和方法公开(公告)号：US07008776B1
公开(公告)日：2006-03-07
申请号：US09277401
申请日：1999-03-26
Applicant: Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
Inventor： Michael Jaye , Kim-Anh Thi Doan , John A. Krawiec , Kevin J. Lynch , Dilip V. Amin , Victoria J. South , Dawn Marchadier , Cyrille Maugeais , Daniel J. Rader
IPC: G01N33/573 , C12N9/20
CPC classification number: G01N33/573 , C12N9/18 , C12N9/20 , G01N2333/918
Abstract: The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid; a neutralizing antibody; an intracellular binding protein; an inhibitor which inhibits the enzymatic activity of LIPG polypeptide; an inhibitor which inhibits the expression of LIPG gene; a ribozyme; an LIPG polypeptide; an enhancer which increases the enzymatic activity of LIPG polypeptide; or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions.In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.
Abstract translation: 本发明涉及用于提高或降低患者中LIPG多肽水平的组合物。 组合物的实施方案包括组合物，其包含：反义核酸; 中和抗体; 细胞内结合蛋白; 抑制LIPG多肽的酶活性的抑制剂; 抑制LIPG基因表达的抑制剂; 核酶; LIPG多肽; 增强LIPG多肽的酶活性的增强剂; 或增加LIPG基因表达的增强子。 本发明还涉及使用上述组合物的方法。 另外本发明还涉及一种用于诊断低胆固醇倾向的方法，一种测定化合物是否能抑制LIPG多肽与HDL胆固醇之间的酶反应的方法，以及用于确定测试化合物是否可以增强酶反应的方法 LIPG多肽和LDL或VLDL胆固醇之间。
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公开(公告)号：US5827826A
公开(公告)日：1998-10-27
申请号：US743261
申请日：1996-11-04
Applicant: Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
Inventor： Michael Jaye , Wilson Burgess , Thomas Maciag , William N. Drohan
CPC classification number: C07K14/501 , A61K38/00 , Y10S930/12
Abstract: The present invention is directed to compositions comprising endothelial cell growth factor, an acceptable carrier and, optionally, an extracellular matrix protein, a glycosaminoglycan or serum albumin. The compositions are useful for wound repair.
Abstract translation: 本发明涉及包含内皮细胞生长因子，可接受的载体和任选的细胞外基质蛋白，糖胺聚糖或血清白蛋白的组合物。 组合物可用于伤口修复。
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