Abstract:
Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
Abstract:
The rotating pile for undergrounding contains a pile-head pipe having a longitudinal center line, a pipe wall, one end portion, and the other end portion opposite to the one end portion. Three or four recessed portions in which the pipe wall is recessed toward the center line are formed in the one end portion. Blades defined by the pipe wall are formed between the adjacent recessed portions. Each of the recessed portions is inclined from the circumferential surface of the pile-head pipe toward the center line. The pipe wall defining one of the adjacent recessed portions contact with the pipe wall defining the other recessed portion so as to cause the one end to be substantially closed. The blades extend radially outward from the center line. The blades gradually expand in the circumferential direction of the pile-head pipe from its top end toward its base end portion.
Abstract:
A device for fitting an elastic ring such as a piston seal, O-ring or the like into an inner circumferential groove of an article such as a hydraulic cylinder or the like. The device comprises a support supporting the article, a tubular retaining member having an inner circumferential groove, means supplying the elastic ring transversely into the groove of the retaining member through a cut-out portion formed in the retaining member, a chucking member adapted to be inserted into the retaining member and into the article for receiving the elastic ring from the retaining member and delivering the elastic ring into the article, means for deforming elastically at least a portion of the elastic ring radially inwardly in delivering the elastic ring from the retaining member to the chucking member, and a clamping mechanism provided on the chucking member for clamping the elastically deformed ring in translating the chucking member from the retaining member to the article.
Abstract:
A programmable controller includes two CPU units each having a detachably attached special-function module for carrying out a calculation process, each of the two CPU units recognizing conditions of the other CPU unit, one of them becoming an active unit and the other becoming a standby unit such that when the active unit fails and goes down the standby unit is switched to become active and resumes operations. The special-function module attached to the active CPU unit becomes an active module and carries out control processes with the active CPU unit and the other special-function module attached to the standby CPU unit becomes a standby module.
Abstract:
In the polishing system of the present invention, a adhering unit adheres a wafer on a carrying plate using liquid. A polishing unit polishes the wafer using a polishing plate. A feeding unit conveys the carrying plate from the adhering unit to the polishing unit. A dismounting unit removes the wafer from the carrying plate. A first discharging unit conveys the carrying plate from the polishing unit to the dismounting unit. A cleaning unit cleans the vacant carrying plate. A second discharging unit conveys the carrying plate from the dismounting unit to the cleaning unit. A third discharging unit conveys the carrying plate from the cleaning unit to the adhering unit. The units are formed into a loop lines so that the carrying plate is circulated in the loop line and the wafers are polished therein.
Abstract:
A polishing machine of the present invention is capable of uniformly polishing a member to be polished with high flatness, and polishing cloth, which is employed in the polishing machine, is uniformly abraded. In the polishing machine, a polishing plate is capable of rotating. A supporting table rotatably supports the polishing plate. A rotary driving mechanism is mounted on the supporting table, and it rotates the polishing plate. A base supports the supporting table. An orbital driving mechanism moves the supporting table along a circular orbit without spinning about its own axis.
Abstract:
Novel 5-alkylidene-4-substituted-2-cyclopentenones and 5-(1-hydroxy-aliphatic hydrocarbon)-4-substituted-2-cyclopentenones.These novel cyclopentenones and 5-alkylidene-3-hydroxy-4-substituted cyclopentanones have a pharmaceutical activity for treatment of tumors.
Abstract:
Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
Abstract:
Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.
Abstract:
A composite sleeve for use in a hot-rolling roll for H-section steel and channel steel comprises a working layer adapted to contact the material to be rolled and composed of two layers, i.e., a first outer layer made of one of adamite with graphite, spheroidal graphite cast iron and adamite having high resistance to sticking, and a second outer layer made of adamite or high chromium iron having high resistance to wear; and an inner layer adapted to be out of contact with the material and made of spheroidal graphite cast steel or spheroidal graphite cast iron having high toughness. The first outer layer covers the second outer layer, and the second outer layer covers the inner layer, the three layers of the first outer layer, the second outer layer and the inner layer being joined together by melting.