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公开(公告)号：US09625388B2
公开(公告)日：2017-04-18
申请号：US12762703
申请日：2010-04-19
申请人： Masaki Ishisaka , Kazuki Kishi , Masakazu Fukuda
发明人： Masaki Ishisaka , Kazuki Kishi , Masakazu Fukuda
CPC分类号： G01N21/6486 , G01N15/147 , G01N2015/0092 , G01N2015/1497
摘要： A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided. The cell analysis apparatus (10) includes: an optical detection section (3) for flowing a measurement sample obtained from a biological sample and a pigment into a flow cell (51), irradiating the measurement sample flowing in the flow cell (51) with laser beam and detecting fluorescence from the measurement sample; a signal processing circuit (4) for acquiring, based on a fluorescence signal outputted from the detection section (3), a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal; and a system control section (13) for distinguishing between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value reflecting the height of the waveform of the fluorescence signal and the value reflecting the length of the ridge line of the waveform of the fluorescence signal obtained by the signal processing circuit (4).
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2.发明授权公开(公告)号：US08992101B2
公开(公告)日：2015-03-31
申请号：US13883870
申请日：2011-12-19
申请人： Masakazu Fukuda , Ryuichiro Sato , Hisao Yui , Hiroshi Takayanagi
发明人： Masakazu Fukuda , Ryuichiro Sato , Hisao Yui , Hiroshi Takayanagi
IPC分类号： G02B6/255
CPC分类号： G02B6/255 , G02B6/2553 , G02B6/2558
摘要： An optical fiber reinforcing heating device has a base part, to which a first lid part for covering a sleeve accommodation groove for containing a fiber reinforcement sleeve covering a fusion-splicing part of optical fibers is attached so as to be openable and closable. A pair of fiber holders for holding and securing the optical fibers are disposed on both end sides of the first lid part. Each fiber holder has a second lid part which is attached to a fiber container so as to be openable and closable and presses the optical fiber against the fiber container. A switch lever which is movable longitudinally of the sleeve accommodation groove is disposed on the upper face of the second lid part built in with a pin adapted to move in conjunction with the switch lever. A joint hole adapted to engage the pin is formed within the first lid part.
摘要翻译： 一种光纤加强加热装置，具有基部，该第一盖部用于覆盖覆盖光纤的熔接部的纤维增强套筒的套筒收容槽，该套筒收容槽被安装成可开闭的。 用于保持和固定光纤的一对光纤保持器设置在第一盖部分的两端侧。 每个纤维保持器具有第二盖部分，其附接到纤维容器以便可打开和关闭，并将光纤按压在纤维容器上。 在套筒容纳槽纵向移动的开关杆设置在第二盖部分的上表面上，该第二盖部分内置有适于与开关杆一起移动的销。 在第一盖部分内形成适于接合销的接合孔。
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公开(公告)号：US20120279359A1
公开(公告)日：2012-11-08
申请号：US13511487
申请日：2010-11-22
IPC分类号： G02B6/245
CPC分类号： G02B6/245 , B25B7/00 , H02G1/1212 , H02G1/1224 , H02G1/1241 , H02G1/1275
摘要： An optical fiber jacket remover draws a glass fiber out from a coating by cutting the coating in a jacket removing portion and moving an optical fiber holding portion away from a jacket remover main unit in a heated state. The jacket removing portion is provided with a heater supporting member on which a heater is mounted. The heater supporting member is accommodated in a recessed receiving portion formed in a case. A heat insulating space is formed between the recessed receiving portion and the heater supporting member. A side surface of the heater supporting member and an inside surface of a lateral wall of the recessed receiving portion are brought into contact with each other via a lateral rib formed on the heater supporting member, and the heat insulating space is thereby blocked.
摘要翻译： 光纤护套去除器通过切割护套去除部分中的涂层并且在加热状态下将光纤保持部分从夹套去除器主单元移开而从涂层中抽出玻璃纤维。 护套移除部分设置有加热器支撑构件，加热器支撑构件安装在加热器支撑构件上。 加热器支撑构件容纳在形成在壳体中的凹入的接收部分中。 在凹入的接收部分和加热器支撑构件之间形成绝热空间。 加热器支撑构件的侧表面和凹入的接收部分的侧壁的内表面通过形成在加热器支撑构件上的横向肋彼此接触，并且隔热空间被阻挡。
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公开(公告)号：US08008089B2
公开(公告)日：2011-08-30
申请号：US11238896
申请日：2005-09-29
申请人： Masakazu Fukuda , Yutaka Ikeda , Hiromi Onomichi
发明人： Masakazu Fukuda , Yutaka Ikeda , Hiromi Onomichi
CPC分类号： G01N15/1459 , G01N9/36 , G01N21/41 , G01N33/493 , G01N35/00603 , G01N2015/008 , G01N2015/1488 , G01N2035/00326 , Y10T436/10 , Y10T436/101666 , Y10T436/103332 , Y10T436/115831
摘要： A system for checking measurement results is provided with a urine qualitative analyzer for measuring the specific gravity of a urine, urinary particle analyzer for measuring urine conductivity, and a computer. The urine specific gravity measured by the urine qualitative analyzer, and the urine conductivity measured by the urinary particle analyzer are respectively transmitted to the computer. The correlative relationship between urine specific gravity and urine conductivity is stored in the memory of the computer, and the computer determines whether or not the received urine specific gravity and conductivity match the correlative relationship, and this determination result is output.
摘要翻译： 用于检查测量结果的系统具有用于测量尿比重的尿定性分析仪，用于测量尿导电性的尿粒分析仪和计算机。 通过尿定性分析仪测定的尿比重和由尿粒分析仪测得的尿电导率分别传送到计算机。 尿比重与尿液电导率之间的相关关系存储在计算机的存储器中，计算机确定接收到的尿比重和电导率是否与相关关系匹配，并输出该确定结果。
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公开(公告)号：US07800742B2
公开(公告)日：2010-09-21
申请号：US12286702
申请日：2008-10-01
申请人： Masakazu Fukuda , Masaki Ishisaka
发明人： Masakazu Fukuda , Masaki Ishisaka
CPC分类号： G01N15/147 , G01N15/1434 , G01N15/1459 , G01N2015/1477 , G01N2021/6439
摘要： The present invention is to present a cell analyzer capable of measuring cells which are approximately 20 to 100 μm in size with high precision via flow cytometry. The cell analyzer 10 comprises: a flow cell 51 in which a measurement sample including a measurement target cell flows; a light source part 53 for irradiating a light on the measurement sample flowing in the flow cell 51; an optical system 52 for forming a beam spot on the measurement sample flowing in the flow cell 51, the beam spot having a diameter of 3˜8 μm in a flow direction of the measurement sample and a diameter of 300˜600 μm in a direction perpendicular to the flow direction of the measurement sample; and a light receiving part 55, 58, 59 for receiving a light from the measurement sample.
摘要翻译： 本发明提供一种能够通过流式细胞术以高精度测量大小为约20至100μm的细胞的细胞分析仪。 细胞分析装置10包括：流动池51，其中包括测量目标细胞的测量样本流动; 用于对在流动池51中流动的测量样品照射光的光源部53; 用于在流动池51中流动的测量样品上形成束斑的光学系统52，在测量样品的流动方向上具有直径为3〜8μm的束斑，在测量样品的流动方向上的直径为300〜600μm 垂直于测量样品的流动方向; 以及用于接收来自测量样品的光的光接收部分55,58,59。
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公开(公告)号：US5695721A
公开(公告)日：1997-12-09
申请号：US549215
申请日：1995-10-27
申请人： Nobuhiro Kitagawa , Masakazu Fukuda
发明人： Nobuhiro Kitagawa , Masakazu Fukuda
CPC分类号： B01F7/244 , Y10T436/2575
摘要： A specimen stirring device has a stirring impeller on a rotating shaft enclosed in a pipe having one or more side holes in a central portion thereof and a nozzle portion at its end and by rotation of the stirring impeller can create a circulating flow of specimen liquid flowing out of the pipe through the nozzle portion, upward along the outside of the pipe and back into the pipe through the side holes and thereby efficiently stir a specimen liquid in a specimen container even if the specimen container is long and slender or has a tapered bottom and without there being a possibility of the stirring impeller and the specimen container making contact with and damaging each other. A specimen sampling apparatus including this specimen stirring device is also disclosed.
摘要翻译： 样品搅拌装置在旋转轴上具有搅拌叶轮，旋转轴包含在其中心部分中具有一个或多个侧孔的管中，其端部处的喷嘴部分和搅拌叶轮的旋转可产生流动的样品液体的循环流动 通过喷嘴部分从管子的外部向上并且通过侧孔返回到管中，从而有效地搅拌样本容器中的样本液体，即使样本容器长而细长或具有锥形底部 并且不存在搅拌叶轮和样品容器彼此接触和损坏的可能性。 还公开了一种包括该样品搅拌装置的标本取样装置。
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公开(公告)号：US20090091746A1
公开(公告)日：2009-04-09
申请号：US12286702
申请日：2008-10-01
申请人： Masakazu Fukuda , Masaki Ishisaka
发明人： Masakazu Fukuda , Masaki Ishisaka
CPC分类号： G01N15/147 , G01N15/1434 , G01N15/1459 , G01N2015/1477 , G01N2021/6439
摘要： The present invention is to present a cell analyzer capable of measuring cells which are approximately 20 to 100 μm in size with high precision via flow cytometry. The cell analyzer 10 comprises: a flow cell 51 in which a measurement sample including a measurement target cell flows; a light source part 53 for irradiating a light on the measurement sample flowing in the flow cell 51; an optical system 52 for forming a beam spot on the measurement sample flowing in the flow cell 51, the beam spot having a diameter of 3˜8 μm in a flow direction of the measurement sample and a diameter of 300˜600 μm in a direction perpendicular to the flow direction of the measurement sample; and a light receiving part 55, 58, 59 for receiving a light from the measurement sample.
摘要翻译： 本发明是提供能够通过流式细胞术以高精度大小测量大约20〜100μm的细胞的细胞分析装置。 细胞分析装置10包括：流动池51，其中包括测量目标细胞的测量样本流动; 用于对在流动池51中流动的测量样品照射光的光源部53; 用于在流动池51中流动的测量样品上形成束斑的光学系统52，在测量样品的流动方向上具有直径为3〜8μm的束斑，在方向上具有300〜600μm的直径 垂直于测量样品的流动方向; 以及用于接收来自测量样品的光的光接收部分55,58,59。
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公开(公告)号：US07174266B2
公开(公告)日：2007-02-06
申请号：US11213699
申请日：2005-08-30
申请人： Hiromi Onomichi , Masakazu Fukuda
发明人： Hiromi Onomichi , Masakazu Fukuda
IPC分类号： G06F15/00
CPC分类号： G01N35/00594 , G01N35/00603 , G01N2035/00891
摘要： An analyzer that comprises a sample measuring mechanism for measuring a sample and generating a measurement value, a memory for storing a plurality of standard values for evaluation of the measurement value, the plurality of standard values including a fixed standard value and a variable standard value, a controlller for evaluating the measurement value based on the standard values; and an output device for outputting result of the evaluation of the measurement value by the evaluation means is disclosed. A computer program product is also disclosed.
摘要翻译： 一种分析器，包括：用于测量样本并产生测量值的样本测量机构;存储器，用于存储用于评估测量值的多个标准值;所述多个标准值包括固定标准值和可变标准值; 控制器，用于基于标准值来评估测量值; 并且公开了一种用于输出评估装置对测量值的评估结果的输出装置。 还公开了一种计算机程序产品。
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公开(公告)号：US6118522A
公开(公告)日：2000-09-12
申请号：US288503
申请日：1999-04-08
申请人： Kazuyuki Kanai , Masakazu Fukuda
发明人： Kazuyuki Kanai , Masakazu Fukuda
CPC分类号： G01N15/1429 , G01N33/493 , G01N15/1459 , G01N2015/0065 , G01N2015/1493
摘要： An apparatus for differentiating erythrocytes in urine includes: a sheath flow cell for forming a urine specimen flow by surrounding a urine specimen with a sheath liquid, the urine specimen containing particles; a light application device for applying light to the urine specimen flow; a light detector for detecting a light signal emitted by each particle in the urine specimen flow; an identification device for identifying erythrocytes from the particles in the urine specimen flow in accordance with the detected light signal; a particle size distribution preparing device for preparing a particle size distribution diagram of the identified erythrocytes; a determining device for determining an origin of the erythrocytes in accordance with an erythrocyte size value at which an accumulated frequency of erythrocytes as counted from a smallest size in the particle size distribution diagram agrees with a preset value larger than half of a total accumulated frequency in the particle size distribution diagram; and an output device for outputting a determination result.
摘要翻译： 用于分离尿液中的红细胞的装置包括：用鞘液包围尿液样本形成尿液样本流的鞘流池，含有颗粒的尿液样本; 用于向所述尿液样本流施加光的光施加装置; 光检测器，用于检测尿液样本流中每个颗粒发射的光信号; 根据检测到的光信号，从尿液样本中的颗粒中鉴定红细胞的识别装置; 用于制备鉴定的红细胞的粒度分布图的粒度分布制备装置; 用于根据红细胞大小值确定红细胞的来源的确定装置，其中在粒度分布图中从最小尺寸计数的红细胞的累积频率与大于总体累积频率的一半的预设值一致 粒度分布图; 以及输出装置，用于输出确定结果。
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公开(公告)号：US5173740A
公开(公告)日：1992-12-22
申请号：US733612
申请日：1991-07-22
CPC分类号： G01N15/1404
摘要： A flow cell for a fluid particle analyzer comprises a narrow measuring liquid path, liquid introducing paths continuous to this measuring liquid path, liquid specimen nozzles disposed so that the front ends may be opposite to each other across the measuring liquid path, and sheath liquid inlets and waste liquid outlets disposed in the liquid introducing paths, respectively.The particle analyzer is designed to emit light to the liquid specimen flowing as a sheath flow in the measuring liquid path in the flow cell and detect the light from the particles individually. Since two liquid specimen nozzles are disposed opposite to each other, measurements from the liquid specimen discharging from one of the liquid specimen nozzles can take place while preparation of the other liquid specimen takes place, so that the analysis processing time can be notably shortened.
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