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    Sulfoximine and suldodiimine matrix metalloproteinase inhibitors
    2.
    发明授权
    Sulfoximine and suldodiimine matrix metalloproteinase inhibitors 失效
    磺酰亚胺和sododiimine基质金属蛋白酶抑制剂

    公开(公告)号：US5470834A

    公开(公告)日：1995-11-28

    申请号：US132411

    申请日：1993-10-06

    Applicant: Martin A. Schwartz ,  Harold Van Wart

    Inventor： Martin A. Schwartz ,  Harold Van Wart

    IPC: A61K38/00 ,  C07C381/10 ,  C07D209/18 ,  C07D233/54 ,  C07D233/64 ,  C07D263/26 ,  C07D403/12 ,  C07K5/06 ,  C07K5/065 ,  A61K38/05 ,  A61K38/06 ,  C07K5/062

    CPC classification number: C07D233/64 ,  C07C381/10 ,  C07D209/18 ,  C07D263/26 ,  C07D403/12 ,  C07K5/06 ,  C07K5/06078 ,  A61K38/00 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/843 ,  Y10S514/912

    Abstract: Novel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of the formula, ##STR1## wherein: R.sup.1 is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino lower-alkyl, carbamoyl lower-alkyl, lower-alkyl carbonyl, lower-alkyoxyalkyl, aralkyl and heteroaralkyl;X is NH or O;R.sup.2 is selected from the group consisting of hydrogen, lower-alkyl and aralkyl;R.sup.3 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, aralkyl and heteroaralkyl; andR.sup.4 is selected from the group consisting of lower alkyl, aralkyl and --CH(R.sup.5)--C(O)NH.sub.2,wherein R.sup.5 is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, imidazoylalkyl, hydroxymethyl, 1-hydroxyethyl, mercapto lower-alkyl, and methylthio lower-alkyl;useful for modulating physiological functions or treating diseases and disease conditions associated with matrix metalloproteinase modulation.

    Abstract translation: 新型的亚砜亚胺和亚磺酰亚胺基质金属蛋白酶抑制剂，其分子式为：其中：R1选自低级烷基，羟基低级烷基，氨基低级烷基，氨基甲酰基低级烷基，低级烷基羰基， 低级烷氧基烷基，芳烷基和杂芳烷基; X是NH或O; R2选自氢，低级烷基和芳烷基; R 3选自氢，低级烷基，氨基低级烷基，鸟嘌呤低级烷基，芳烷基和杂芳烷基; 并且R 4选自低级烷基，芳烷基和-CH（R 5）-C（O）NH 2，其中R 5选自氢，低级烷基，氨基低级烷基，脒基低级烷基 ，咪唑基烷基，羟甲基，1-羟乙基，巯基低级烷基和甲硫基低级烷基; 可用于调节生理功能或治疗与基质金属蛋白酶调节相关的疾病和疾病状况。

    Method of inhibiting vascular permeability
    3.
    发明授权
    Method of inhibiting vascular permeability 有权
    抑制血管通透性的方法

    公开(公告)号：US07442681B2

    公开(公告)日：2008-10-28

    申请号：US11054789

    申请日：2005-02-10

    Applicant: Martin A. Schwartz ,  Rebecca A. Stockton

    Inventor： Martin A. Schwartz ,  Rebecca A. Stockton

    IPC: A61K38/00 ,  C07K17/00 ,  C12Q1/06

    CPC classification number: C12N9/1205 ,  A61K38/005 ,  Y10S435/81

    Abstract: The present invention provides a method of regulating vascular permeability. A peptide inhibitor of p21-activated kinase has been found to inhibit the increase in vascular permeability induced by several factors. The present invention further provides methods of identifying regulators of vascular permeability. This peptide or other p21-activated kinase inhibitors should therefore be useful to treat disorders where vascular leak is a contributing factor.

    Abstract translation: 本发明提供调节血管通透性的方法。 已经发现p21激活的激酶的肽抑制剂抑制由几种因素引起的血管渗透性的增加。 本发明还提供鉴定血管通透性调节剂的方法。 因此，该肽或其他p21激活的激酶抑制剂应用于治疗血管渗漏是促成因素的疾病。

    Cleavable cross-linking reagent
    4.
    发明授权
    Cleavable cross-linking reagent 失效
    可切割交联试剂

    公开(公告)号：US4647671A

    公开(公告)日：1987-03-03

    申请号：US694698

    申请日：1985-01-25

    Applicant: Martin A. Schwartz

    Inventor： Martin A. Schwartz

    IPC: C07D207/40 ,  C07D207/404 ,  G01N33/534 ,  G01N33/60 ,  C07D207/452

    CPC classification number: C07D207/404 ,  G01N33/534 ,  G01N33/60

    Abstract: An alkali-cleavable heterobifunctional cross-linking analytical reagent is provided in the form of a compound having the structure ##STR1## in which R.sub.1 and R.sub.2 is each an alkylene group having from 2 to 4 carbon atoms.

    Abstract translation: 提供了具有结构（2-羟基-5-叠氮基苯甲酰基）-NHR1 + TR 的化合物形式的碱可裂解异双功能交联分析试剂，其中R 1和R 2各自为具有2 至4个碳原子。

    Analog/digital voice storage cellular telephone
    6.
    再颁专利
    Analog/digital voice storage cellular telephone 失效
    模拟/数字语音存储蜂窝电话

    公开(公告)号：USRE34976E

    公开(公告)日：1995-06-20

    申请号：US13022

    申请日：1993-02-01

    Applicant: Richard J. Helferich ,  Martin A. Schwartz

    Inventor： Richard J. Helferich ,  Martin A. Schwartz

    IPC: H04B1/66 ,  H04M1/725 ,  H04M1/65 ,  H04M11/00

    CPC classification number: H04M1/725 ,  H04B1/662 ,  H04M1/6505

    Abstract: An analog-to-digital voice storage cellular telephone for recording voice messages while the user is away from the cellular telephone unit. In a preferred embodiment, the analog-to-digital voice storage cellular telephone comprises call answering circuitry which is activated after a predetermined number of rings. Detection circuitry waits to detect a SAT signal during a preset period of time. Once the SAT signal is detected a prerecorded outgoing message is transmitted to the caller. The voice storage cellular telephone records incoming voice messages. which are retrieved and replayed by users at their convenience. If the SAT signal is not detected, call terminating circuitry immediately terminates call. In accordance with one aspect, voice messages may be recorded at the central cellular station in real time, subsequently transmitted to the voice storage cellular telephone at a high speed and reproduced at normal speed to reduce air transmission time and cost.

    Methods of use for integrin B.sub.1C cell growth inhibitor
    10.
    发明授权
    Methods of use for integrin B.sub.1C cell growth inhibitor 失效
    整合素B1C细胞生长抑制剂的使用方法

    公开(公告)号：US06013495A

    公开(公告)日：2000-01-11

    申请号：US951200

    申请日：1997-10-14

    Applicant: Martin A. Schwartz ,  Jere E. Meredith, Jr. ,  Yoshikazu Takada ,  Lucia Languino

    Inventor： Martin A. Schwartz ,  Jere E. Meredith, Jr. ,  Yoshikazu Takada ,  Lucia Languino

    IPC: A61K38/00 ,  C07K14/705 ,  C12N1/38 ,  C07K7/08 ,  C07K14/435 ,  C12N13/00

    CPC classification number: C07K14/7055 ,  A61K38/00

    Abstract: The present invention provides a method for inhibiting cell proliferation in a cell comprising contacting the cell with a nucleic acid sequence or a polypeptide having essentially the sequence of the .beta..sub.1C integrin. Also included in the invention are peptides consisting of amino acid residues which are the size of or fewer than the sequence of the cytoplasmic domain of the .beta..sub.1C integrin consisting essentially of the amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2, and functional fragments thereof which are useful for inhibiting cellular proliferation. Peptides, polynucleotides, and antibodies immunoreactive with the peptides, and methods of use for inhibiting cell growth are also provided.

    Abstract translation: 本发明提供了抑制细胞中细胞增殖的方法，包括使细胞与基本上具有β1C整联蛋白序列的核酸序列或多肽接触。 本发明还包括由基本上由SEQ ID NO：1和SEQ ID NO：2的氨基酸序列组成的β1C整联蛋白的大小或小于其序列的氨基酸残基的肽 及其功能片段，其可用于抑制细胞增殖。 还提供了肽，多核苷酸和与肽免疫反应的抗体，以及用于抑制细胞生长的方法。

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