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公开(公告)号：US20220310273A1
公开(公告)日：2022-09-29
申请号：US17239118
申请日：2021-04-23
申请人： MBD Co., Ltd.
发明人： Bo Sung KU , Jung Eun KIM
摘要： The system for evaluating sensitivity to an anticancer drug according to the embodiment of the present invention includes a communication unit configured to receive biological test data of a biological specimen isolated from a biological individual and a processor connected to the communication unit, where the processor is configured to determine anticancer drug sensitivity of the biological individual in terms of whether treatment response is positive or negative based on the biological test data, by using a sensitivity prediction model configured to determine sensitivity to an anticancer drug based on an anticancer drug response factor and a cell growth factor, and then to provide results of evaluation on the sensitivity of the biological individual to the anticancer drug.
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公开(公告)号：US20220373462A1
公开(公告)日：2022-11-24
申请号：US17739403
申请日：2022-05-09
申请人： MBD Co., Ltd. , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION , Research & Business Foundation SUNGKYUNKWAN UNIVERSITY
发明人： Bo Sung KU , Jung Eun KIM , Man Ki CHUNG , Dong Woo LEE
摘要： The present invention is directed to a method of measuring cell migration by measuring the invasion ratio of cells incubated on a pillar array inserted into a well structure, the method including steps of: preparing a pillar array having a plurality of micropillars and a well structure having a plurality of microwells into which the plurality of micropillars is insertable, respectively; forming cell spheroids by incubating cells in an extracellular matrix attached to the end contact surfaces of the micropillars; allowing the cells contained in the cell spheroids to invade the end contact surfaces; staining and scanning the cell spheroids, the cells contained in the cell spheroids, and the cells that invaded the end contact surfaces; and calculating the invasion ratio of cells by the following equation through a fluorescence image of the scanned cells: Invasion Ratio = Invasion cell area Total cell area = A Total - A spheroid A Total [ Equation ] wherein Atotal represents the total cell area, and Aspheroid represents the spheroid area.
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公开(公告)号：US10967369B2
公开(公告)日：2021-04-06
申请号：US16073624
申请日：2018-03-30
申请人： MBD CO., LTD.
发明人： Bo Sung Ku , Don Jung Lee
IPC分类号： B01L3/00
摘要： The present invention relates to a pillar structure for a biochip and includes a substrate which has a plate-shaped structure, and pillar members, each of which has one side detachably coupled to the substrate and the other side on which a sample is disposed.
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公开(公告)号：US20180361373A1
公开(公告)日：2018-12-20
申请号：US16061277
申请日：2016-12-12
发明人： Don Jung LEE , Ho Jeong SONG , Dong Woo LEE , Do Hyun NAM
摘要： Technology for a pillar structure for a biochip is disclosed. The pillar structure for a biochip includes: a substrate portion having a plate structure; an insertion pillar portion formed in one piece with the substrate portion and protruding downward from a lower surface of the substrate portion so as to be inserted into a well; and a compensation pillar portion formed in one piece with the substrate portion, the compensation pillar portion corresponding to the insertion pillar portion and protruding upward from an upper surface of the substrate portion. Therefore, when the pillar structure is cooled during an injection molding process, the substrate portion is prevented from being partially recessed, and when samples are analyzed using microscopic images, accuracy and reliability may be improved.
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公开(公告)号：US12092575B2
公开(公告)日：2024-09-17
申请号：US17739403
申请日：2022-05-09
申请人： MBD Co., Ltd. , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION , Research & Business Foundation SUNGKYUNKWAN UNIVERSITY
发明人： Bo Sung Ku , Jung Eun Kim , Man Ki Chung , Dong Woo Lee
CPC分类号： G01N21/64 , C12M23/12 , G01N33/5005 , G01N2021/6439
摘要： The present invention is directed to a method of measuring cell migration by measuring the invasion ratio of cells incubated on a pillar array inserted into a well structure, the method including steps of: preparing a pillar array having a plurality of micropillars and a well structure having a plurality of microwells into which the plurality of micropillars is insertable, respectively; forming cell spheroids by incubating cells in an extracellular matrix attached to the end contact surfaces of the micropillars; allowing the cells contained in the cell spheroids to invade the end contact surfaces; staining and scanning the cell spheroids, the cells contained in the cell spheroids, and the cells that invaded the end contact surfaces; and calculating the invasion ratio of cells by the following equation through a fluorescence image of the scanned cells:
Invasion
Ratio
=
Invasion
cell
area
Total
cell
area
=
A
Total
-
A
spheroid
A
Total
[
Equation
]
wherein Atotal represents the total cell area, and Aspheroid represents the spheroid area.-
公开(公告)号：US20220402890A1
公开(公告)日：2022-12-22
申请号：US17775773
申请日：2020-11-11
申请人： MBD CO., LTD.
发明人： Ho Sang Moon , Bosung Ku , Jungwon Kim , Do Hyeong Na , Gun Hwa Kim , Sin Hyoung Hong , Min Ji Lee , Ji Hoon Lee
IPC分类号： C07D401/12 , C07D401/14 , A61P3/10 , A61P1/16 , A23L33/10
摘要： The present invention relates to a novel quinoline compound and a use thereof and to a novel quinoline compound exhibiting CYP4A inhibition activity and a use thereof for preventing, alleviating, treating a metabolic disease. The compound disclosed in the present invention has a remarkable effect of inhibiting CYP4A and exhibits the activities of promoting the absorption of glucose into hepatocytes, inhibiting fat accumulation in hepatocytes, suppressing endoplasmic reticulum-induced reactive oxygen species, and treating steatohepatitis, and thus can be very advantageously used for developing therapeutics for metabolic diseases such as diabetes mellitus and fatty liver.
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公开(公告)号：US10954481B2
公开(公告)日：2021-03-23
申请号：US16132006
申请日：2018-09-14
申请人： MBD CO., LTD.
发明人： Bosung Ku
摘要： A pillar unit for a bio chip can include a plate-form substrate having a plurality of holder parts, which are spaced apart from each other, and each of the plurality of holder parts includes a holding space, to which a pillar is inserted and fixed, in which each of the plurality of holder parts further includes a pair transformation slits so that the corresponding holder part may be transformed and restored while the pillar is accommodated in the holding space; and a plurality of pillars corresponding to the plurality of holder parts, each of the plurality of pillars is accommodated in the holding space in one of the plurality of holder parts, one end of each of the plurality of pillars is combined with one holder part among the plurality of holder parts and is detachable, and the other end of each of the pillars includes a sample.
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公开(公告)号：US20240287032A1
公开(公告)日：2024-08-29
申请号：US18289752
申请日：2022-05-04
申请人： MBD CO., LTD.
发明人： Bo Sung KU , Ho Sang MOON , Do Hyeong NA , Mi Sun KIM , Han Som PARK
IPC分类号： C07D401/14 , A61K31/496 , A61K31/517 , A61P1/16 , A61P3/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/14 , A61K31/496 , A61K31/517 , A61P1/16 , A61P3/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a novel quinoline or quinazoline compound and the use thereof. The compound according to the present invention shows an excellent inhibitory activity against cytochrome P450 4A (CYP4A) and thus may be utilized for preventing, relieving or treating metabolic diseases.
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公开(公告)号：US20210380916A1
公开(公告)日：2021-12-09
申请号：US17285048
申请日：2019-11-05
申请人： MBD CO., LTD.
发明人： Bo Sung KU , Dong Woo LEE
摘要： The present invention relates to a pillar structure for a biochip. The pillar structure for a biochip according to the present invention is provided to form a biochip for analyzing a sample, which is a biological micromaterial such as a cell, together with a well plate configured to receive a culture solution, and the pillar structure includes: a pillar part having a seating surface on which a cell for culture is placed, and a light irradiation surface configured to be irradiated with light for observing the cell placed on the seating surface; and a plurality of holder parts extending in a state of being spaced apart from the pillar part and having an opening between the adjacent holder parts so that the culture solution is introduced between the holder parts.
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公开(公告)号：US20190233789A1
公开(公告)日：2019-08-01
申请号：US16132006
申请日：2018-09-14
申请人： MBD CO., LTD.
发明人： Bosung KU
CPC分类号： C12M23/12 , B01L3/5085 , B01L3/50853 , B01L2200/025 , B01L2200/028 , B01L2200/10 , B01L2300/046 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , C12M23/42 , C12M23/44 , C12M25/06 , C12M31/02 , G01N33/5302
摘要： Provided is a pillar unit for a bio chip. The pillar unit for a bio chip according to the present invention is to form a bio chip along with a well plate, in which a culture medium is accommodated, wherein the bio chip analyzes samples of biological micro-substances such as cells, and may include: a plate-form substrate including a plurality of holder parts, which is spaced apart from each other, arranged vertically and horizontally, and includes a holding space, to which an object is inserted and fixed, wherein each of the holder parts includes transformation slits so that the holder part may be transformed and restored while the object is accommodated in the holding space; and a plurality of pillars corresponding to the above object which is accommodated in the holding space of the substrate, wherein one end of the pillar is combined with each holder part and is detachable, and the other end of the pillar includes the sample.
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