公开(公告)号：US5643681A

公开(公告)日：1997-07-01

申请号：US473723

申请日：1995-06-07

Applicant: Marc Voorhees ,  Lloyd Forrestal ,  Harold Fisher

Inventor： Marc Voorhees ,  Lloyd Forrestal ,  Harold Fisher

IPC: A61L33/00 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06 ,  B01D67/00 ,  C08G77/42 ,  C08J7/00 ,  C09D183/10 ,  B32B27/32 ,  B32B27/36

CPC classification number: B01D67/0088 ,  A61L27/34 ,  A61L31/10 ,  A61L33/068 ,  C09D183/10 ,  Y10T428/249978 ,  Y10T428/24998 ,  Y10T428/249992 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31681 ,  Y10T428/31786 ,  Y10T428/31797

Abstract: The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.

Abstract translation: 与血液接触使用的聚合物和金属制品的生物相容性可以通过如上所述涂覆制品而大大改善。 涂层材料是聚内酯 - 聚硅氧烷 - 聚内酯型的三嵌段共聚物。 最佳生物相容性由最佳表面浓度的涂层提供。 可以如所述涂覆多孔膜，提供改善的血液氧合器，血液透析器等的生物相容性。

公开(公告)号：US5962563A

公开(公告)日：1999-10-05

申请号：US748163

申请日：1996-11-12

Applicant: Lloyd Forrestal ,  Marc Voorhees

Inventor： Lloyd Forrestal ,  Marc Voorhees

IPC: B29C33/38 ,  B29C67/24 ,  C08J5/00 ,  C08J5/54

CPC classification number: B29C33/38 ,  B29C67/24 ,  C08J5/00 ,  B29K2995/0026 ,  B29K2995/0056

Abstract: The surface free energy of a polymer blend where a base polymer contains an additive having a different surface free energy than that of the base polymer can be controlled over a wide range of additive surface concentrations by appropriate choice of the mold surface free energy during fabrication. A high surface concentration of additive relative to a low bulk concentration can be achieved, leading to improved biocompatibility without loss of optical clarity.

Abstract translation: 聚合物共混物的表面自由能，其中基础聚合物含有具有与基础聚合物不同的表面自由能的添加剂，可以通过在制造过程中适当选择模具表面自由能，在广泛的添加剂表面浓度范围内进行控制。 可以实现相对于低体积浓度的高表面浓度的添加剂，导致改善的生物相容性而不损失光学透明度。

公开(公告)号：US5738902A

公开(公告)日：1998-04-14

申请号：US728824

申请日：1996-10-10

Applicant: Lloyd Forrestal ,  Marc Voorhees ,  Harold Fisher

Inventor： Lloyd Forrestal ,  Marc Voorhees ,  Harold Fisher

IPC: A61L33/00 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06 ,  B01D67/00 ,  C08G77/42 ,  C08J7/00 ,  C09D183/10 ,  B05D3/06

CPC classification number: B01D67/0088 ,  A61L27/34 ,  A61L31/10 ,  A61L33/068 ,  C09D183/10 ,  Y10T428/249978 ,  Y10T428/24998 ,  Y10T428/249992 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31681 ,  Y10T428/31786 ,  Y10T428/31797

Abstract: The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.

Abstract translation: 与血液接触使用的聚合物和金属制品的生物相容性可以通过如上所述涂覆制品而大大改善。 涂层材料是聚内酯 - 聚硅氧烷 - 聚内酯型的三嵌段共聚物。 最佳生物相容性由最佳表面浓度的涂层提供。 可以如所述涂覆多孔膜，提供改善的血液氧合器，血液透析器等的生物相容性。

公开(公告)号：US5354472A

公开(公告)日：1994-10-11

申请号：US981912

申请日：1992-11-23

Applicant: Marc Voorhees ,  Ben F. Brian, III ,  Lloyd Forrestal

Inventor： Marc Voorhees ,  Ben F. Brian, III ,  Lloyd Forrestal

IPC: G01N30/00 ,  A61M1/36 ,  B01D15/08 ,  B01J20/26 ,  B01J20/28 ,  B01J20/281 ,  B01J20/285 ,  B01J20/32 ,  B01J41/12 ,  B01J41/16 ,  C08J5/22 ,  D04H1/44 ,  D04H1/46 ,  G01N30/88 ,  C02J5/20

CPC classification number: C08J5/2275 ,  A61M1/3675 ,  B01J41/16 ,  B01J41/20 ,  C08J5/2212 ,  D04H1/44 ,  D04H1/46 ,  C08J2301/08 ,  C08J2435/02

Abstract: A novel biocompatible anion exchange membrane is prepared by reacting the hydroxyl groups of a chromatographic support material with a polyester-cellulose solution containing glycidyl trimethyl ammonium chloride and bis glycidyl polyethylene oxide.

Abstract translation: 通过使色谱载体材料的羟基与含有缩水甘油基三甲基氯化铵和双缩水甘油基聚环氧乙烷的聚酯 - 纤维素溶液反应来制备新的生物相容性阴离子交换膜。

公开(公告)号：US5702823A

公开(公告)日：1997-12-30

申请号：US728823

申请日：1996-10-10

Applicant: Lloyd Forrestal ,  Marc Voorhees ,  Yung-Ming Chen ,  Richard A. Edrich

Inventor： Lloyd Forrestal ,  Marc Voorhees ,  Yung-Ming Chen ,  Richard A. Edrich

IPC: A61L33/00 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06 ,  B01D67/00 ,  C08G77/42 ,  C08J7/00 ,  C09D183/10 ,  B32B15/08

CPC classification number: B01D67/0088 ,  A61L27/34 ,  A61L31/10 ,  A61L33/068 ,  C09D183/10 ,  Y10T428/249978 ,  Y10T428/24998 ,  Y10T428/249992 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31681 ,  Y10T428/31786 ,  Y10T428/31797

Abstract: The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.