知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.019 秒)

    Oxysulfonyl urea ACAT inhibitors
    1.
    发明授权
    Oxysulfonyl urea ACAT inhibitors 失效
    氧基磺酰脲ACAT抑制剂

    公开(公告)号：US5364882A

    公开(公告)日：1994-11-15

    申请号：US984028

    申请日：1992-12-01

    申请人： Joseph A. Picard ,  Drago R. Sliskovic

    发明人： Joseph A. Picard ,  Drago R. Sliskovic

    IPC分类号： A61K31/415 ,  A61K20060101 ,  A61K31/445 ,  A61K31/47 ,  A61K31/472 ,  A61K31/64 ,  A61P3/06 ,  A61P3/08 ,  A61P9/10 ,  C07C20060101 ,  C07C307/02 ,  C07D20060101 ,  C07D211/16 ,  C07D213/40 ,  C07D217/00 ,  C07D231/40 ,  C07D261/08 ,  C07D261/14 ,  C07D263/32 ,  C07D263/48 ,  C07D295/20 ,  C07D307/14 ,  C07D333/20 ,  A61K31/255 ,  C07C309/63

    CPC分类号： C07C307/02

    摘要： Compounds of the formula ##STR1## wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein each of R.sub.1 and R.sub.2 is hydrogen, an aralkyl group, a straight or branched hydrocarbon group having from 1 to 20 carbon atoms and may be saturated or unsaturated, an alkyl group of from 1 to 6 carbon atoms wherein the terminal carbon is substituted, the group --(CH.sub.2).sub.p)--Q wherein p is zero to three and Q is a 5- or 6-membered monocyclic or fused bicyclic heterocycle, phenyl or NR.sub.1 R.sub.2 taken together form a monocyclic heterocyclic ring, and R.sub.3 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, --(CH.sub.2).sub.p --Q wherein p and Q are as defined above, an aralkyl group or a straight or branched hydrocarbon group having from 1 to 20 carbon atoms and being straight or branched, which compounds are useful in treating hypercholesterolemia.

    摘要翻译： 其中R为氢，具有1至8个碳原子的直链或支链烷基或苄基的式IMAMA的化合物; 其中R 1和R 2各自为氢，芳烷基，具有1至20个碳原子并且可以是饱和或不饱和的直链或支链烃基，其中末端碳被取代的具有1至6个碳原子的烷基， 基团 - （CH 2）p）-Q其中p为0至3，Q为5或6元单环或稠合双环杂环，苯基或NR 1 R 2一起形成单环杂环，并且R 3为苯基，取代的苯基 ，萘基，取代的萘基， - （CH 2）pQ其中p和Q如上所定义，芳烷基或具有1至20个碳原子的直链或支链烃基是直链或支链的，该化合物可用于治疗高胆固醇血症 。

    Oxysulfonyl carbamates
    5.
    发明授权
    Oxysulfonyl carbamates 失效
    氧化磺酰基氨基甲酸酯

    公开(公告)号：US5384328A

    公开(公告)日：1995-01-24

    申请号：US65716

    申请日：1993-05-21

    申请人： Joseph A. Picard ,  Drago R. Sliskovic

    发明人： Joseph A. Picard ,  Drago R. Sliskovic

    IPC分类号： C07C307/02 ,  C07C333/12 ,  A61K31/27

    CPC分类号： C07C333/12 ,  C07C307/02

    摘要： The present invention is directed to compounds of the following general Formula I, methods for using the compounds of Formula I, pharmaceutical compositions thereof, and processes for preparing the compounds. ##STR1## wherein X is oxygen or sulfur; wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl;wherein each of R.sub.1 and R.sub.2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a 5- or 6-membered monocyclic or fused bicyclic heterocyclic group, or a hydrocarbon chain having from 1 to 20 carbon atoms and from 1 to 3 double bonds.

    摘要翻译： 本发明涉及以下通式I的化合物，使用式I化合物的方法，其药物组合物及其制备方法。 式Ⅰ其中X是氧或硫; 其中R是氢，具有1至8个碳原子的直链或支链烷基或苄基; 其中R 1和R 2各自为苯基，取代的苯基，萘基，取代的萘基，芳烷基，5-或6-元单环或稠合双环杂环基，或具有1至20个碳原子和1至 3双键。

    Sulfonyl urea and carbamate ACAT inhibitors
    7.
    发明授权
    Sulfonyl urea and carbamate ACAT inhibitors 失效
    磺酰脲和氨基甲酸酯ACAT抑制剂

    公开(公告)号：US5254589A

    公开(公告)日：1993-10-19

    申请号：US776112

    申请日：1991-10-15

    申请人： Joseph A. Picard ,  William H. Roark ,  Bruce D. Roth

    发明人： Joseph A. Picard ,  William H. Roark ,  Bruce D. Roth

    IPC分类号： C07C311/53 ,  C07C311/55 ,  A61K31/175

    CPC分类号： C07C311/53 ,  C07C311/55

    摘要： A pharmaceutically useful compound which lowers blood cholesterol levels having the formula ##STR1## wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; R.sub.1 is hydrogen, lower alkyl or benzyl; and R.sub.2 is a straight or branched alkyl group having from 5 to 17 carbon atoms which may be substituted on the 1-carbon position with methyl, ethyl, phenyl, or substituted phenyl, or a cycloalkyl group having from 3 to 8 carbon atoms.

    摘要翻译： 降低具有式“IMAGE”的血液胆固醇水平的药学上有用的化合物，其中X是氧或-NH-; Ar是苯基，取代的苯基，萘基或取代的萘基; R1是氢，低级烷基或苄基; 并且R 2是具有5至17个碳原子的直链或支链烷基，其可以在1-碳位上被甲基，乙基，苯基或取代的苯基或具有3至8个碳原子的环烷基取代。

    Oxysulfonyl carbamates
    8.
    发明授权
    Oxysulfonyl carbamates 失效
    氧化磺酰基氨基甲酸酯

    公开(公告)号：US5245068A

    公开(公告)日：1993-09-14

    申请号：US15662

    申请日：1993-02-09

    申请人： Joseph A. Picard ,  Drago R. Sliskovic

    发明人： Joseph A. Picard ,  Drago R. Sliskovic

    IPC分类号： C07C307/02 ,  C07C333/12

    CPC分类号： C07C333/12 ,  C07C307/02

    摘要： The present invention is directed to compounds of the following general Formula I, methods for using the compounds of Formula I, pharmaceutical compositions thereof, and processes for preparing the compounds. ##STR1## wherein X is oxygen or sulfur; wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein each of R.sub.1 and R.sub.2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a 5- or 6-membered monocyclic or fused bicyclic heterocyclic group, or a hydrocarbon chain having from 1 to 20 carbon atoms and from 1 to 3 double bonds.

    摘要翻译： 本发明涉及以下通式I的化合物，使用式I化合物的方法，其药物组合物及其制备方法。 式Ⅰ其中X是氧或硫; 其中R是氢，具有1至8个碳原子的直链或支链烷基或苄基; 其中R 1和R 2各自为苯基，取代的苯基，萘基，取代的萘基，芳烷基，5-或6-元单环或稠合双环杂环基，或具有1至20个碳原子和1至 3双键。

    .alpha.-aryl or heteroaryl-substituted amide ester ACAT inhibitors
    10.
    发明授权
    .alpha.-aryl or heteroaryl-substituted amide ester ACAT inhibitors 失效
    α-芳基或杂芳基取代的酰胺酯ACAT抑制剂

    公开(公告)号：US5502198A

    公开(公告)日：1996-03-26

    申请号：US398704

    申请日：1995-03-06

    申请人： Joseph A. Picard ,  Drago R. Sliskovic

    发明人： Joseph A. Picard ,  Drago R. Sliskovic

    IPC分类号： C07D239/42 ,  A61K31/215 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/505 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C233/11 ,  C07C233/22 ,  C07C233/29 ,  C07D213/56 ,  C07D213/55

    CPC分类号： C07D213/56 ,  C07C233/11 ,  C07C233/29

    摘要： Pharmaceutically useful compounds having acyl-coenzyme A: cholesterol acyltransferase inhibitory activity having the general formula ##STR1## wherein Ar is di- or trisubstituted aryl or heteroaryl; R.sub.14 and R.sub.15 are each independently aryl, heteroaryl, hydrogen, fluorine, or alkyl, with the proviso that R.sub.14 and R.sub.15 are not both hydrogen, fluorine, or a straight or branched chain alkyl or a combination thereof; and R.sub.16 is a straight or branched hydrocarbon chain having 1 to 20 carbon atoms and is saturated or unsaturated and has 1 to 3 double bonds, the double bonds being adjacent or nonadjacent.

    摘要翻译： 具有酰基辅酶A的药用有用化合物：具有通式的胆固醇酰基转移酶抑制活性，其中Ar是二取代或三取代的芳基或杂芳基; R 14和R 15各自独立地为芳基，杂芳基，氢，氟或烷基，条件是R 14和R 15不同时为氢，氟或直链或支链烷基或其组合; R16为碳原子数为1〜20的直链或支链烃链，为饱和或不饱和的1〜3个双键，双键相邻或不相邻。