公开(公告)号：US09132294B2

公开(公告)日：2015-09-15

申请号：US13158947

申请日：2011-06-13

申请人： Qian Zheng ,  Siming W. Chen ,  Uma Santhanam ,  John W. Lyga

发明人： Qian Zheng ,  Siming W. Chen ,  Uma Santhanam ,  John W. Lyga

IPC分类号： A61K36/00 ,  A61Q19/08 ,  A61K8/46 ,  A61K8/49 ,  A61K8/97

CPC分类号： A61K8/97 ,  A61K8/466 ,  A61K8/49 ,  A61K31/5377 ,  A61K36/185 ,  A61K36/39 ,  A61K36/53 ,  A61K36/74 ,  A61K45/06 ,  A61K2800/20 ,  A61Q19/00 ,  A61Q19/08

摘要： The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.

摘要翻译： 本公开内容涉及用于治疗，预防和改善皮肤的状况和美学外观的方法，特别是通过施用一种或其组合来治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹 刺激MAGP-1表达的天然化合物或提取物，并改善老化和/或光损伤皮肤的外观。 本发明的组合物局部施用于皮肤，或通过定向方式递送至有效改善皮肤状况和美观外观的量的有需要的部位。

公开(公告)号：US08686013B2

公开(公告)日：2014-04-01

申请号：US13217870

申请日：2011-08-25

申请人： John W. Lyga

发明人： John W. Lyga

IPC分类号： A01N43/76 ,  A61K31/42

CPC分类号： C07D263/34 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

摘要： Cosmetic compositions comprising substituted amino heterocyclic carbamoyl analogs and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The substituted amino heterocyclic carbamoyl analogs are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.

摘要翻译： 公开了包含取代的氨基杂环氨基甲酰基类似物的化妆品组合物和使用这些组合物以赋予皮肤抗衰老益处的方法。 认为取代的氨基杂环氨基甲酰基类似物对于涉及皮肤老化的一种或多种生物化学途径具有调节活性。

公开(公告)号：US20110257195A1

公开(公告)日：2011-10-20

申请号：US13164915

申请日：2011-06-21

申请人： Dmitri S. Ptchelintsev ,  Hong Hu ,  Gopinathan K. Menon ,  Kristine Schmalenberg ,  John W. Lyga

发明人： Dmitri S. Ptchelintsev ,  Hong Hu ,  Gopinathan K. Menon ,  Kristine Schmalenberg ,  John W. Lyga

IPC分类号： A61K8/49 ,  A61Q19/00 ,  A61Q19/08

CPC分类号： A61K31/496 ,  A61K8/494 ,  A61Q19/00 ,  A61Q19/08

摘要： Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.

公开(公告)号：US07767667B2

公开(公告)日：2010-08-03

申请号：US12196893

申请日：2008-08-22

申请人： John A. Dixson ,  Zeinab M. Elshenawy ,  Harvey R. Wendt ,  Saroj Sehgel ,  Robert H. Henrie, II ,  David M. Roush ,  Ping Ding ,  John W. Lyga ,  Stephen F. Donovan

发明人： John A. Dixson ,  Zeinab M. Elshenawy ,  Harvey R. Wendt ,  Saroj Sehgel ,  Robert H. Henrie, II ,  David M. Roush ,  Ping Ding ,  John W. Lyga ,  Stephen F. Donovan

IPC分类号： A01N43/50 ,  A61P7/04 ,  C07D233/20 ,  C07D405/04 ,  C07D403/04

CPC分类号： A01N43/88 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/76 ,  A01N43/78 ,  C07D211/70 ,  C07D211/74 ,  C07D233/10 ,  C07D233/20 ,  C07D233/22 ,  C07D233/24 ,  C07D233/26 ,  C07D233/64 ,  C07D263/14 ,  C07D273/04 ,  C07D277/14 ,  C07D307/06 ,  C07D307/12 ,  C07D307/20 ,  C07D309/18 ,  C07D309/20 ,  C07D309/22 ,  C07D309/30 ,  C07D333/08 ,  C07D333/16 ,  C07D333/32 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07F9/6506 ,  C07F9/6533 ,  C07F9/65586

摘要： It has now been found that certain novel heterocyclic derivitives have provided unexpected insecticidal activity. These compounds are represented by formula (I): R Preferred are those compounds of formula (I) where R2 and R3 taken together is ═NCH(R6)CH(R7)N(R8)—, ═NC(R6)═C(R7)N(R8)—, or ═CHN═C(R7)N(R8)—, and tautomers thereof, and where R4 and R5 taken together is —C(R11)═C(R12)C(R13)═C(R14) 1 12, -, where R,R,R6, R7, R8, RI1, R R13, R14, and X are described. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound with at least one insecticidally compatable carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 现在已经发现某些新的杂环衍生物已经提供了意想不到的杀虫活性。 这些化合物由式（I）表示：R优选的是式（I）的化合物，其中R 2和R 3一起是= NCH（R6）CH（R7）N（R8） - ，= NC（R6）= C（ R 7）N（R 8） - 或= CHN = C（R 7）N（R 8） - 及其互变异构体，其中R 4和R 5一起为-C（R 11）= C（R 12）C（R 13） （R14）112， - ，其中描述了R，R，R 6，R 7，R 8，R 1c，R 13，R 14和X。 此外，还公开了包含杀虫有效量的至少一种式（I）化合物和任选的有效量的至少一种具有至少一种杀虫相容性载体的第二化合物的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US20100152045A1

公开(公告)日：2010-06-17

申请号：US11915974

申请日：2006-05-24

申请人： John W. Lyga ,  Frank Zawacki ,  Larry Y. Zhang

发明人： John W. Lyga ,  Frank Zawacki ,  Larry Y. Zhang

IPC分类号： A01N43/64 ,  C07D249/06 ,  A01N43/713 ,  C07D257/04 ,  C07D249/08 ,  A01N43/653 ,  A01N43/836 ,  C07D271/06

CPC分类号： C07D249/06 ,  C07D233/56 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D271/06 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/06 ,  C07D413/04 ,  C07D413/06

摘要： Certain novel phenylalkyl substituted azole derivatives have unexpected insecticidal activity. These compounds are represented by formula I: where A, B, D, E, G, a, b, c, d, and R through R11, inclusively, are folly described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 某些新的苯基烷基取代的唑衍生物具有出人意料的杀虫活性。 这些化合物由式I表示：其中A，B，D，E，G，a，b，c，d和R至R 11包括本文中所述。 此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US07576224B2

公开(公告)日：2009-08-18

申请号：US11292023

申请日：2005-12-01

申请人： George Theodoridis ,  Edward J. Barron ,  Dominic P. Suarez ,  Y. Larry Zhang ,  Ping Ding ,  David M. Roush ,  Stephen F. Donovan ,  Frank J. Zawacki ,  Walter H. Yeager ,  John W. Lyga ,  Daniel H. Cohen

发明人： George Theodoridis ,  Edward J. Barron ,  Dominic P. Suarez ,  Y. Larry Zhang ,  Ping Ding ,  David M. Roush ,  Stephen F. Donovan ,  Frank J. Zawacki ,  Walter H. Yeager ,  John W. Lyga ,  Daniel H. Cohen

IPC分类号： C07D307/80 ,  C07D495/10

CPC分类号： A01N43/30 ,  A01N43/32 ,  A01N43/40 ,  A01N43/60 ,  A01N47/16 ,  C07D211/22 ,  C07D307/79 ,  C07D307/83 ,  C07D311/04 ,  C07D401/04 ,  C07D495/10

摘要： Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives of Formula I are disclosed. These compounds provide unexpected insecticidal activity across a spectrum of insect pests combined with desirable physical properties including improved photostability. wherein x and y are integers independently selected from 0 or 1; and B is a bridging group *—(CR16R17)q—(CR18R19)r—(CR20R21)s-Lt-(CR22R23)u—(CR24R25)v—(CR26R27)w—, where the asterisk denotes attachment at A; and q, r, s, u, v and w are integers independently selected from 0, 1 and 2; and t is an integer selected from 0 and 1. A, D, E, G, M, R through R11, and R16 through R27, inclusively, are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I and methods of controlling insects by applying said compositions to a locus where insects are present or are expected to be present are also disclosed.

摘要翻译： 公开了杀虫（二卤代丙烯基）苯基烷基取代的二氢苯并呋喃和式I的二氢苯并吡喃衍生物。 这些化合物在一系列昆虫害虫中提供了意想不到的杀虫活性，并结合所需的物理性质，包括改善的光稳定性。 其中x和y是独立地选自0或1的整数; * - （CR16R17）q-（CR18R19）r-（CR20R21）s-Lt-（CR22R23），而B是桥接基团<？in-line-formula description =“In-line Formulas”end =“lead” u-（CR24R25）v-（CR26R27）w - ，<？在线公式描述=“在线公式”end =“tail”？>其中星号表示在A附近; q，r，s，u，v和w是独立地选自0,1和2的整数; 并且t是选自0和1的整数。本文充分描述了A，D，E，G，M，R至R 11和R 16至R 27。 此外，还公开了包含杀虫有效量的至少一种式I化合物的组合物和通过将所述组合物施用于存在昆虫或预期存在的场所来控制昆虫的方法。

公开(公告)号：US20090082203A1

公开(公告)日：2009-03-26

申请号：US11721661

申请日：2005-12-09

申请人： John W. Lyga ,  David S. Rosen ,  Y. Larry Zhang ,  Ping Ding ,  Robert N. Henrie, II ,  Frank J. Zawacki ,  Charles E. Hatch, III ,  Shunxiang Zhang ,  Jaidev S. Goudar

发明人： John W. Lyga ,  David S. Rosen ,  Y. Larry Zhang ,  Ping Ding ,  Robert N. Henrie, II ,  Frank J. Zawacki ,  Charles E. Hatch, III ,  Shunxiang Zhang ,  Jaidev S. Goudar

IPC分类号： A01N43/40 ,  C07D211/00 ,  A01P15/00

CPC分类号： C07D405/10 ,  C07D401/10 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D411/10 ,  C07D413/10

摘要： It has now been found that certain novel bis(substituted phenyl)-1 {[4-(saturated heterocyclyl-substituted)phenyl-methyl](4-piperidyl)}methane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I); where R through R15, m, n, s, A, B, D and W are defined herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 现已发现某些新的双（取代苯基）-1 {[4-（饱和杂环基取代的）苯基 - 甲基]（4-哌啶基）}甲烷衍生物提供了意想不到的杀虫活性。 这些化合物由式（I）表示; 其中R至R 15，m，n，s，A，B，D和W如本文所定义。 此外，还公开了包含杀虫有效量的至少一种式（I）化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：US07300946B2

公开(公告)日：2007-11-27

申请号：US10538998

申请日：2003-12-08

申请人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Steven Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

发明人： Ping Ding ,  Robert N. Henrie, II ,  Daniel H. Cohen ,  John W. Lyga ,  David S. Rosen ,  George Theodoridis ,  Qun Zhang ,  Walter H. Yeager ,  Stephen F. Donovan ,  Steven Shunxiang Zhang ,  Inna Shulman ,  Seong Jae Yu ,  Guozhi Wang ,  Y. Larry Zhang ,  Ariamala Gopalsamy ,  Dennis L. Warkentin ,  Paul E. Rensner ,  Ian R. Silverman ,  Thomas G. Cullen

IPC分类号： A61K31/44 ,  A61K31/445 ,  A61K31/4422 ,  C07D211/06 ,  C07D211/08 ,  C07D211/70 ,  C07D211/82

CPC分类号： C07D405/14 ,  A01N43/40 ,  A01N43/54 ,  A01N43/713 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/24 ,  C07D211/26 ,  C07D211/28 ,  C07D211/32 ,  C07D211/94 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/14 ,  C07D513/04

摘要： It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present

摘要翻译： 现在已经发现，某些新的N-（取代的芳基）-4（二取代的甲基）哌啶和吡啶衍生物已经提供了意想不到的杀虫活性。 这些化合物由式（I）表示：其中m，n，q，r和s独立地选自0或1; 且p为0,1,2或3; A是C或CH; 和B，D，E，R，R 1，R 2，R 3，R 4，R 本文中充分描述了本发明的第5，第6，第七和第八和第八。 此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所

公开(公告)号：US07208450B2

公开(公告)日：2007-04-24

申请号：US10510331

申请日：2004-04-28

申请人： George Theodoridis ,  Edward J. Barron ,  Dominic P. Suarez ,  Y. Larry Zhang ,  Ping Ding ,  John W. Lyga ,  Matthew P. Whiteside

发明人： George Theodoridis ,  Edward J. Barron ,  Dominic P. Suarez ,  Y. Larry Zhang ,  Ping Ding ,  John W. Lyga ,  Matthew P. Whiteside

IPC分类号： A01N43/76 ,  A01N43/78 ,  C07D263/54 ,  C07D277/62

CPC分类号： A01N43/30 ,  A01N43/32 ,  A01N43/40 ,  A01N43/60 ,  A01N47/16 ,  C07D211/22 ,  C07D307/79 ,  C07D307/83 ,  C07D311/04 ,  C07D401/04 ,  C07D495/10

摘要： Certain novel (dihalopropenyl)phenylalkyl substituted benzoxazole and benzothiazole derivatives have unexpected insecticidal activity. These compounds are represented by formula (I): where R through R11, inclusively. x, A, B, y, D, E and G are fully described herein. Preferred compounds of the present invention are those wherein the benzo-fused ring moiety is attached to the remainder of the molecule at the positions designated as (5) or (6) and where R11 is either C1–C3 alkyl or halo C1–C3 alkyl. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

摘要翻译： 某些新的（二卤代丙烯基）苯基烷基取代的苯并恶唑和苯并噻唑衍生物具有出人意料的杀虫活性。 这些化合物由式（I）表示：其中R 1至R 11包括。 这里完整地描述了x，A，B，y，D，E和G。 本发明优选的化合物是其中苯并稠环部分在（5）或（6）表示的位置连接到分子的其余部分，其中R 11是C < C 1 -C 3烷基或卤素C 1 -C 3烷基。 此外，还公开了包含杀虫有效量的至少一种式（I）化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

公开(公告)号：USH2007H1

公开(公告)日：2001-12-04

申请号：US08780371

申请日：1997-01-09

申请人： Ian R. Silverman ,  Syed F. Ali ,  Daniel H. Cohen ,  John W. Lyga ,  Kirk A. Simmons ,  Thomas G. Cullen

发明人： Ian R. Silverman ,  Syed F. Ali ,  Daniel H. Cohen ,  John W. Lyga ,  Kirk A. Simmons ,  Thomas G. Cullen

IPC分类号： C07D29500

摘要： Compounds of the following structure are disclosed as effective insecticides: in which: A and B are independently lower alkyl; U is lower alkylidene, lower alkenylidene, or CH—Z, where Z is hydrogen, lower alkyl, lower cycloalkyl, or phenyl; R is phenyl or a dibenzocyclo(C5-8)alkyl, each optionally substituted, or where R3 and R4 are independently selected from phenyl, optionally substituted with, halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkenyl, or phenyl; R1 is selected from a variety of substituents, including 3-R2, where R2 is where D, E, and G are hydrogen, hydroxy, halogen, cyano, hydroxy, lower alkyl, lower haloalkyl, lower alkoxy, nitro, lower haloalkylsuffonyloxy, lower alkylcarboxylato, lower alkylcarbonylamino, lower alkylcarbonyl, lower alkoxycarbonyl, arylcarbonylamino; D and E taken together may form the group —O(CH2)O—; J is hydrogen or lower alkyl; m is 2 or 3, n is 1, 2, or 3; and halogen is chlorine, bromine, or fluorine.