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公开(公告)号：US09926601B2
公开(公告)日：2018-03-27
申请号：US14000995
申请日：2012-02-24
申请人： Frank B. Gertler , Christopher Boyce Burge , Irina M. Shapiro , Wu Albert Cheng , John S. Condeelis , Maja H. Oktay
发明人： Frank B. Gertler , Christopher Boyce Burge , Irina M. Shapiro , Wu Albert Cheng , John S. Condeelis , Maja H. Oktay
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57415
摘要： The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
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2.发明授权Tumor microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors 有权肿瘤微环境转移瘤（TMEM）及其在肿瘤诊断，预后和治疗中的应用公开(公告)号：US08642277B2
公开(公告)日：2014-02-04
申请号：US12804779
申请日：2010-07-29
IPC分类号： G01N33/567 , G01N33/574 , C07K16/28 , C07K16/30
CPC分类号： G01N33/574 , G01N33/57484 , G01N2333/70503 , G01N2333/70596 , G01N2800/52 , G01N2800/56
摘要： Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.
摘要翻译： 公开了用于确定经历转移的肿瘤细胞的风险的方法，用于评估对局部肿瘤进行治疗的受试者的预后，以及用于确定局部肿瘤的治疗过程，包括检测内皮细胞，巨噬细胞， 和侵入性肿瘤细胞直接结合在受试者的肿瘤样品中。
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3.发明申请Tumor Microenvironment of metastasis (TMEM) and uses thereof in diagnosis, prognosis and treatment of tumors 有权肿瘤转移微环境（TMEM）及其在肿瘤诊断，预后和治疗中的应用公开(公告)号：US20110059470A1
公开(公告)日：2011-03-10
申请号：US12804779
申请日：2010-07-29
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： G01N33/574 , G01N33/57484 , G01N2333/70503 , G01N2333/70596 , G01N2800/52 , G01N2800/56
摘要： Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor cell in direct apposition in a tumor sample from a subject.
摘要翻译： 公开了用于确定经历转移的肿瘤细胞的风险的方法，用于评估对局部肿瘤进行治疗的受试者的预后，以及用于确定局部肿瘤的治疗过程，包括检测内皮细胞，巨噬细胞， 和侵入性肿瘤细胞直接结合在受试者的肿瘤样品中。
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4.发明申请Isolation, Gene Expression, and Chemotherapeutic Resistance of Motile Cancer Cells 有权免疫细胞的分离，基因表达和化疗抗性公开(公告)号：US20080138805A1
公开(公告)日：2008-06-12
申请号：US11659514
申请日：2005-08-04
申请人： John S. Condeelis
发明人： John S. Condeelis
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/118 , G01N33/5005 , G01N33/5029 , G01N33/56966 , G01N33/574
摘要： Methods of isolating motile cells of interest from an animal tissue is provided. Also provided are methods of determining mRNA or protein expression of a gene in motile cells of interest from an animal tissue. Additionally, methods of determining whether a cancer in a tissue of a mammal is likely to metastasize are provided. Methods are also provided for inhibiting metastasis of a cancer in a tissue of a mammal. Further provided are methods of determining resistance of a motile cancer cell population in an animal tissue to a chemotherapeutic agent.
摘要翻译： 提供从动物组织分离感兴趣的细胞的方法。 还提供了从动物组织确定感兴趣的运动细胞中的基因的mRNA或蛋白质表达的方法。 此外，提供了确定哺乳动物组织中的癌症是否可能转移的方法。 还提供了用于抑制哺乳动物组织中癌症转移的方法。 还提供了确定动物组织中的运动性癌细胞群体对化学治疗剂的抗性的方法。
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5.发明申请METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS 有权METASASIS特异性SPRICE变体及其在诊断，预后和治疗肿瘤中的应用公开(公告)号：US20140057966A1
公开(公告)日：2014-02-27
申请号：US14074089
申请日：2013-11-07
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/713
CPC分类号： C12Q1/6886 , A61K31/713 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57438 , G01N33/57496
摘要： Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
摘要翻译： 提供了转移性肿瘤的诊断，预后和治疗的方法和试剂盒，其中转移性肿瘤的特征在于Mena的+++，++和/或11a变体的表达变化。
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公开(公告)号：US20120322685A1
公开(公告)日：2012-12-20
申请号：US13574831
申请日：2011-01-14
IPC分类号： C12Q1/24 , C40B30/04 , G01N33/574
CPC分类号： G01N33/5029 , A61B10/02 , G01N33/5091
摘要： The present invention provides a method of isolating motile cells from an animal tissue, the method comprising implanting in the animal tissue a cell trap comprising a chamber with an inlet for ingress of motile cells and a porous matrix located in the chamber comprising a chemotactic factor, for a time sufficient for the motile cells to migrate into the cell trap; removing the implanted cell trap; and retrieving the motile cells from the cell trap.
摘要翻译： 本发明提供了一种从动物组织中分离运动细胞的方法，所述方法包括在动物组织中植入细胞捕获器，该细胞捕获器包括具有用于进入运动细胞的入口的腔室和位于所述腔室中的包含趋化因子的多孔基质， 足够的时间让运动细胞迁移到细胞陷阱中; 去除植入的细胞阱; 以及从细胞捕获器检索运动细胞。
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7.发明申请公开(公告)号：US20170335406A1
公开(公告)日：2017-11-23
申请号：US15661021
申请日：2017-07-27
IPC分类号： C12Q1/68 , A61K31/713 , G01N33/50 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/713 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57438 , G01N33/57496
摘要： Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
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8.发明申请ALTERNATIVELY SPLICED mRNA ISOFORMS AS PROGNOSTIC INDICATORS FOR METASTATIC CANCER 有权作为分泌癌的预后指标的异位mRNA表达公开(公告)号：US20140066319A1
公开(公告)日：2014-03-06
申请号：US14000995
申请日：2012-02-24
申请人： Frank B. Gertler , Christopher Boyce Burge , Irina M. Shapiro , Wu Albert Cheng , John S. Condeelis , Maja H. Oktay
发明人： Frank B. Gertler , Christopher Boyce Burge , Irina M. Shapiro , Wu Albert Cheng , John S. Condeelis , Maja H. Oktay
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , G01N33/57415
摘要： The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively spliced mRNA isoforms of a cell motility gene, a cell adhesion gene and/or an actin cytoskeletal remodeling gene in the sample, or any specified genes or the level of RNA binding proteins compared to a predetermined non-metastasizing control.
摘要翻译： 本发明提供了一种用于鉴定可能转移或可能转移的肿瘤的方法，包括获得肿瘤样品并定量细胞运动性基因，细胞粘附基因和/或肌动蛋白细胞骨架的可变剪接的mRNA同种型 与预定的非转移对照相比，样品中的重塑基因，或任何指定的基因或RNA结合蛋白的水平。
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9.发明申请Metastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors 有权转移特异性剪接变体，其在肿瘤的诊断，预后和治疗中的用途及其用途公开(公告)号：US20100047240A1
公开(公告)日：2010-02-25
申请号：US12462324
申请日：2009-07-31
IPC分类号： C12Q1/68 , C07K5/10 , G01N33/53 , A61K39/395
CPC分类号： C12Q1/6886 , A61K31/713 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57438 , G01N33/57496
摘要： Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
摘要翻译： 提供了转移性肿瘤的诊断，预后和治疗的方法和试剂盒，其中转移性肿瘤的特征在于Mena的+++，++和/或11a变体的表达变化。
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10.发明授权公开(公告)号：US09719142B2
公开(公告)日：2017-08-01
申请号：US14074089
申请日：2013-11-07
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/50 , G01N33/574 , A61K31/713
CPC分类号： C12Q1/6886 , A61K31/713 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57438 , G01N33/57496
摘要： Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
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