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1.发明授权Optical coherence tomography lumen morphology and vascular resistance measurements methods for blood vessel evaluations 有权光学相干断层扫描管腔形态和血管阻力测量方法进行血管评估公开(公告)号：US09572495B2
公开(公告)日：2017-02-21
申请号：US13617441
申请日：2012-09-14
CPC分类号： A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B2034/102 , A61F2/82 , G06T7/0012 , G06T2200/24 , G06T2207/10016 , G06T2207/10101 , G06T2207/30101
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
摘要翻译： 一种自动定位在血管图像中的管腔边界在容器中的位置以及从测量血管直径的方法和装置。 从容器的直径和估计的血流速度，然后确定许多临床显着的生理参数，并且生成各种用户显示关注。 这些图像和参数的一个用途是帮助临床医生放置支架。 在一个实施例中，该系统使用这些测量来允许临床医生模拟支架的放置并确定放置的影响。 此外，从这些患者参数，然后执行各种患者治疗。
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2.发明申请VERSATILE NANOPARTICULATE BIOMATERIAL FOR CONTROLLED DELIVERY AND/OR CONTAINMENT OF THERAPEUTIC AND DIAGNOSTIC MATERIAL 审中-公开用于治疗和诊断材料的控制输送和/或容纳的多种纳米颗粒生物材料公开(公告)号：US20120213697A1
公开(公告)日：2012-08-23
申请号：US13265347
申请日：2010-04-19
申请人： Joel M. Friedman , Adam J. Friedman , George Han , Mahantesh S. Navati , Kevin P. Davies , Moses Tarndie Tar , Alan A. Alfieri , Arturo Casadevall , Ekaterina Dadachova , Helene C. Eisenman , Jasmin N/A , David Spray
发明人： Joel M. Friedman , Adam J. Friedman , George Han , Mahantesh S. Navati , Kevin P. Davies , Moses Tarndie Tar , Alan A. Alfieri , Arturo Casadevall , Ekaterina Dadachova , Helene C. Eisenman , Jasmin N/A , David Spray
IPC分类号： A61K49/00 , A61K33/00 , A61K38/18 , A61K51/12 , A61K47/36 , A61K47/34 , A61K47/24 , A61K49/18 , A61K9/00 , A61K9/50 , A61P35/00 , A61P31/04 , A61P29/00 , A61P15/10 , A61P39/00 , A61K38/02
CPC分类号： A61B5/0478 , A61K9/0034 , A61K9/5036 , A61K9/5161 , A61K45/06
摘要： The invention provides compositions for controlled delivery and/or containment of therapeutic and/or diagnostic agents comprising the agent or agents encapsulated by a matrix containing chitosan, polyethylene glycol (PEG) and/or polyvinyl alcohol (PVA), and tetra-methoxy-ortho-silicate (TMOS) or tetra-ethoxy-ortho-silicate (TEOS), as well as methods for preparing the compositions, and uses of the compositions for therapy and imaging.
摘要翻译： 本发明提供用于受控递送和/或控制治疗和/或诊断试剂的组合物，其包含由含有壳聚糖，聚乙二醇（PEG）和/或聚乙烯醇（PVA）的基质和四甲氧基邻位 硅酸盐（TMOS）或四乙氧基原硅酸盐（TEOS），以及制备组合物的方法，以及该组合物用于治疗和成像的用途。
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公开(公告)号：US08116605B2
公开(公告)日：2012-02-14
申请号：US12886265
申请日：2010-09-20
IPC分类号： G02B6/06
CPC分类号： G02B23/2423 , A61B5/0066 , A61B5/6852 , G02B5/08
摘要： In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.
摘要翻译： 部分地，本发明涉及一种透镜组件。 透镜组件包括微透镜; 与微透镜进行光通信的光束导向器; 和基本透明的薄膜。 基本透明的薄膜能够双向透射光，并产生受控量的反向散射。 另外，胶片围绕光束导向器的一部分。
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4.发明申请Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods 有权流明形态和血管阻力测量数据收集系统，装置和方法公开(公告)号：US20110071404A1
公开(公告)日：2011-03-24
申请号：US12888347
申请日：2010-09-22
CPC分类号： A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B2034/102 , A61F2/82 , G06T7/0012 , G06T2200/24 , G06T2207/10016 , G06T2207/10101 , G06T2207/30101
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
摘要翻译： 一种自动定位在血管图像中的管腔边界在容器中的位置以及从测量血管直径的方法和装置。 从容器的直径和估计的血流速度，然后确定许多临床显着的生理参数，并且生成各种用户显示关注。 这些图像和参数的一个用途是帮助临床医生放置支架。 在一个实施例中，该系统使用这些测量来允许临床医生模拟支架的放置并确定放置的影响。 此外，从这些患者参数，然后执行各种患者治疗。
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5.发明申请Compositions for sustrained release of nitric oxide, methods of preparing same and uses thereof 有权用于一氧化氮的自发释放的组合物，其制备方法及其用途公开(公告)号：US20090297634A1
公开(公告)日：2009-12-03
申请号：US12227657
申请日：2007-06-20
IPC分类号： A61K33/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P9/08 , A61P17/02 , A61P17/14
CPC分类号： A61K33/00 , A61K9/0014 , A61K31/722 , A61K47/10 , A61K47/26 , A61K47/36 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/473 , A61K2300/00
摘要： The invention provides compositions for releasing nitric oxide (NO) comprising a matrix that encapsulates nitric oxide. Nitric oxide is released when the composition is exposed to an aqueous environment. The invention further provides methods of preparing the compositions and uses of the compositions for treating infections and disorders.
摘要翻译： 本发明提供用于释放一氧化氮（NO）的组合物，其包含封装一氧化氮的基质。 当组合物暴露于水性环境时，释放一氧化氮。 本发明还提供了制备用于治疗感染和病症的组合物和用途的方法。
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6.发明授权公开(公告)号：US09138147B2
公开(公告)日：2015-09-22
申请号：US12888347
申请日：2010-09-22
CPC分类号： A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B2034/102 , A61F2/82 , G06T7/0012 , G06T2200/24 , G06T2207/10016 , G06T2207/10101 , G06T2207/30101
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
摘要翻译： 一种自动定位在血管图像中的管腔边界在容器中的位置以及从测量血管直径的方法和装置。 从容器的直径和估计的血流速度，然后确定许多临床显着的生理参数，并且生成各种用户显示关注。 这些图像和参数的一个用途是帮助临床医生放置支架。 在一个实施例中，该系统使用这些测量来允许临床医生模拟支架的放置并确定放置的影响。 此外，从这些患者参数，然后执行各种患者治疗。
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7.发明申请Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods 审中-公开流明形态和血管阻力测量数据采集系统，装置和方法公开(公告)号：US20140276011A1
公开(公告)日：2014-09-18
申请号：US13796710
申请日：2013-03-12
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimate blood flow rate, a number of clinically significant physiological parameters are then determine and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
摘要翻译： 一种自动定位在血管图像中的管腔边界在容器中的位置以及从测量血管直径的方法和装置。 从容器的直径和估计血流速度，然后确定许多临床显着的生理参数，并且生成各种用户显示兴趣。 这些图像和参数的一个用途是帮助临床医生放置支架。 在一个实施例中，该系统使用这些测量来允许临床医生模拟支架的放置并确定放置的影响。 此外，从这些患者参数，然后执行各种患者治疗。
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8.发明申请公开(公告)号：US20180344174A9
公开(公告)日：2018-12-06
申请号：US13796710
申请日：2013-03-12
CPC分类号： A61B5/02007 , A61B5/0066 , A61B5/0084
摘要： A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimate blood flow rate, a number of clinically significant physiological parameters are then determine and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
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公开(公告)号：US09007696B2
公开(公告)日：2015-04-14
申请号：US13617800
申请日：2012-09-14
CPC分类号： G02B23/2423 , A61B5/0066 , A61B5/6852 , G02B5/08
摘要： In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.
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公开(公告)号：US08503844B2
公开(公告)日：2013-08-06
申请号：US13298836
申请日：2011-11-17
CPC分类号： G02B23/2423 , A61B5/0066 , A61B5/6852 , G02B5/08
摘要： In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.
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