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11 条记录 (耗时 0.017 秒)

    Non-woven wash cloth
    3.
    发明授权
    Non-woven wash cloth 有权
    无纺布布

    公开(公告)号：US07427574B2

    公开(公告)日：2008-09-23

    申请号：US11208079

    申请日：2005-08-19

    申请人： Jennifer Allen

    发明人： Jennifer Allen

    IPC分类号： D04H1/40 ,  D04H1/46 ,  B32B27/36 ,  A61M35/00 ,  A01N25/34

    CPC分类号： D04H1/46 ,  D04H1/74 ,  Y10T428/24942 ,  Y10T428/2495 ,  Y10T442/682 ,  Y10T442/684 ,  Y10T442/697

    摘要： A non-woven washcloth formed from a blend of two different size polyester fibers, the majority of which have a length about half of that of the minority. The washcloth has good absorbing and holding properties for a solution containing chlorhexidine gluconate, while also releasing said chlorhexidine gluconate when wiped on skin.

    摘要翻译： 由两种不同尺寸的聚酯纤维的混合物形成的无纺布毛巾，其大部分长度约为少数的纤维的一半。 对于含有洗必泰葡萄糖酸盐的溶液，洗涤布具有良好的吸收和保持性能，同时在擦拭皮肤时也释放出所述氯己定葡萄糖酸氯己定。

    Non-woven wash cloth
    6.
    发明申请
    Non-woven wash cloth 有权
    无纺布布

    公开(公告)号：US20070042666A1

    公开(公告)日：2007-02-22

    申请号：US11208079

    申请日：2005-08-19

    申请人： Jennifer Allen

    发明人： Jennifer Allen

    IPC分类号： D04H1/46 ,  B32B27/32

    CPC分类号： D04H1/46 ,  D04H1/74 ,  Y10T428/24942 ,  Y10T428/2495 ,  Y10T442/682 ,  Y10T442/684 ,  Y10T442/697

    摘要： A non-woven washcloth formed from a blend of two different size polyester fibers, the majority of which have a length about half of that of the minority. The washcloth has good fluid retention properties, and releases fluids in a controlled manner when used.

    摘要翻译： 由两种不同尺寸的聚酯纤维的混合物形成的无纺布毛巾，其大部分长度约为少数的纤维的一半。 洗脸布具有良好的流体保持性能，并在使用时以受控的方式释放流体。

    GFP mutagenesis amplification: use of a fluorescence-antibiotic resistance fusion dual reporter construct to provide quantitative and highly sensitive detection of mutations
    7.
    发明授权
    GFP mutagenesis amplification: use of a fluorescence-antibiotic resistance fusion dual reporter construct to provide quantitative and highly sensitive detection of mutations 有权
    GFP诱变扩增：使用荧光抗生素抗性融合双重报道构建体提供定量和高度灵敏的突变检测

    公开(公告)号：US09068972B2

    公开(公告)日：2015-06-30

    申请号：US13504911

    申请日：2010-11-02

    申请人： Manel Camps ,  Jennifer Allen

    发明人： Manel Camps ,  Jennifer Allen

    IPC分类号： G01N21/64 ,  C12N15/63 ,  C40B30/06 ,  G01N33/50

    CPC分类号： G01N33/5023 ,  C12N15/1086 ,  C12Q1/6897 ,  G01N2500/10

    摘要： A reversion mutation assay that is unique in providing a quantitative readout for mutagenesis. This assay is based on the creation of a functional GFP-β-lactamase fusion protein as a reporter providing both antibiotic resistance and fluorescence. This dual reporter is placed in a multicopy plasmid to increase the number of targets, with a reversion site at the N-terminus. Rare mutations at the reversion site allow read-through of the fusion protein, producing both beta-lactamase (providing antibiotic resistance) and GFP (emitting fluorescence). In the presence of carbenicillin, beta-lactamase production confers a selective advantage that allows amplification of mutant plasmids, raising the level of fluorescence emitted by GFP to levels that are detectable by fluorimetry. A window of time can be found where fluorescence is proportional to the number of mutation events at the reversion site, making fluorescence a quantitative measure of mutagenesis. Quantitative (as opposed to binary) detection of mutations allows substantial savings in test sample. This has applications in drug discovery, allowing high-throughput screening for DNA-targeting compounds and early pre-screening of leads for potential carcinogenic activity. The increased sensitivity of this assay also facilitates monitoring complex environmental samples.

    摘要翻译： 在提供定量读数用于诱变方面独特的逆转突变测定法。 该测定基于产生功能性GFP-＆bgr-β-内酰胺酶融合蛋白作为提供抗生素抗性和荧光的报告物。 将该双重报告物置于多拷贝质粒中以增加靶的数目，其N-末端具有逆转位点。 在反转位点的罕见突变允许融合蛋白的读取，产生β-内酰胺酶（提供抗生素抗性）和GFP（发射荧光）。 在羧苄青霉素存在下，β-内酰胺酶的产生具有允许扩增突变质粒的选择性优势，将GFP发射的荧光水平提高到通过荧光测定可检测的水平。 可以发现一个时间窗口，其中荧光与反转位点处的突变事件的数量成比例，使荧光成为诱变的定量测量。 定量（而不是二元）检测突变可以大大节省测试样品。 这在药物发现中有应用，允许对DNA靶向化合物进行高通量筛选和对潜在致癌活性进行早期预筛选。 该测定的灵敏度增加也有助于监测复杂的环境样品。

    GFP MUTAGENESIS AMPLIFICATION: USE OF A FLUORESCENCE-ANTIBIOTIC RESISTANCE FUSION DUAL REPORTER CONSTRUCT TO PROVIDE QUANTITATIVE AND HIGHLY SENSITIVE DETECTION OF MUTATIONS
    8.
    发明申请
    GFP MUTAGENESIS AMPLIFICATION: USE OF A FLUORESCENCE-ANTIBIOTIC RESISTANCE FUSION DUAL REPORTER CONSTRUCT TO PROVIDE QUANTITATIVE AND HIGHLY SENSITIVE DETECTION OF MUTATIONS 有权
    GFP MUTAGENESIS放大：使用荧光抗性抗性融合双重报告器结构提供定量和敏感性检测突变

    公开(公告)号：US20120302461A1

    公开(公告)日：2012-11-29

    申请号：US13504911

    申请日：2010-11-02

    申请人： Manel Camps ,  Jennifer Allen

    发明人： Manel Camps ,  Jennifer Allen

    IPC分类号： G01N21/64 ,  C12N15/63 ,  C40B30/06

    CPC分类号： G01N33/5023 ,  C12N15/1086 ,  C12Q1/6897 ,  G01N2500/10

    摘要： A reversion mutation assay that is unique in providing a quantitative readout for mutagenesis. This assay is based on the creation of a functional GFP-β-lactamase fusion protein as a reporter providing both antibiotic resistance and fluorescence. This dual reporter is placed in a multicopy plasmid to increase the number of targets, with a reversion site at the N-terminus. Rare mutations at the reversion site allow read-through of the fusion protein, producing both beta-lactamase (providing antibiotic resistance) and GFP (emitting fluorescence). In the presence of carbenicillin, beta-lactamase production confers a selective advantage that allows amplification of mutant plasmids, raising the level of fluorescence emitted by GFP to levels that are detectable by fluorimetry. A window of time can be found where fluorescence is proportional to the number of mutation events at the reversion site, making fluorescence a quantitative measure of mutagenesis. Quantitative (as opposed to binary) detection of mutations allows substantial savings in test sample. This has applications in drug discovery, allowing high-throughput screening for DNA-targeting compounds and early pre-screening of leads for potential carcinogenic activity. The increased sensitivity of this assay also facilitates monitoring complex environmental samples.

    摘要翻译： 在提供定量读数用于诱变方面独特的逆转突变测定法。 该测定基于产生功能性GFP-＆bgr-β-内酰胺酶融合蛋白作为提供抗生素抗性和荧光的报告物。 将该双重报告物置于多拷贝质粒中以增加靶的数目，其N-末端具有逆转位点。 在反转位点的罕见突变允许融合蛋白的读取，产生β-内酰胺酶（提供抗生素抗性）和GFP（发射荧光）。 在羧苄青霉素存在下，β-内酰胺酶的产生具有允许扩增突变质粒的选择性优势，将GFP发射的荧光水平提高到通过荧光测定可检测的水平。 可以发现一个时间窗口，其中荧光与反转位点处的突变事件的数量成比例，使荧光成为诱变的定量测量。 定量（而不是二元）检测突变可以大大节省测试样品。 这在药物发现中有应用，允许对DNA靶向化合物进行高通量筛选和对潜在致癌活性进行早期预筛选。 该测定的灵敏度增加也有助于监测复杂的环境样品。

    Disinfectant delivery system, and method of providing alcohol-free disinfection
    9.
    发明申请
    Disinfectant delivery system, and method of providing alcohol-free disinfection 有权
    消毒剂输送系统和无酒精消毒方法

    公开(公告)号：US20060280648A1

    公开(公告)日：2006-12-14

    申请号：US11507288

    申请日：2006-08-21

    申请人： Thomas Keaty ,  Ram Chakroborty ,  Jennifer Allen ,  Ajay Chawla ,  Robert Panek ,  Paul Hanifl

    发明人： Thomas Keaty ,  Ram Chakroborty ,  Jennifer Allen ,  Ajay Chawla ,  Robert Panek ,  Paul Hanifl

    IPC分类号： A61L2/18

    CPC分类号： A61L2/232 ,  A01N47/44 ,  A61L2/18 ,  Y10T442/682 ,  A01N25/34 ,  A01N2300/00

    摘要： A disinfectant delivery system and method of providing alcohol-free disinfection to a body to be disinfected, as well as a method of infection reduction by preparation of a patient before an invasive procedure. A blended cloth comprising first fibers and second fibers is provided with the first fibers generally being greater in quantity by weight than the second fibers. A disinfectant solution impregnates the blended cloth, with the disinfectant solution having chlorhexidine gluconate as an active ingredient and having no alcohol. In the method according to the invention, at least one impregnated blended cloth is used to disinfect at least a portion of a body. A plurality of blended cloths can be provided for disinfecting discrete portions of the body. When an invasive procedure is to be performed on a patient, a further method according to the invention of infection reduction comprises using a CHG-impregnated cloth to disinfect at least a portion of the patient at least one day prior to the invasive procedure proximate the location of the invasive procedure.

    摘要翻译： 一种消毒剂递送系统和对待消毒的身体提供无酒精消毒的方法，以及通过在侵入性手术之前制备患者感染减少的方法。 提供包含第一纤维和第二纤维的混合布，其中第一纤维的重量通常大于第二纤维的重量。 消毒剂溶液浸渍混合布，消毒剂溶液以葡萄糖酸洗必太为活性成分，不含酒精。 在根据本发明的方法中，使用至少一种浸渍的混合布来对身体的至少一部分进行消毒。 可以提供多个混合布来消毒身体的离散部分。 当对患者进行侵入性手术时，根据本发明的感染减少的另一方法包括使用CHG浸渍的布在邻近位置的侵入性手术之前至少一天对患者的至少一部分进行消毒 的侵入性手术。