Strain-Independent Amplification of Pathogens and Vaccines Thereto
    4.
    发明申请
    Strain-Independent Amplification of Pathogens and Vaccines Thereto 有权
    病原菌和疫苗的应变无关扩增

    公开(公告)号:US20080311155A1

    公开(公告)日:2008-12-18

    申请号:US11662828

    申请日:2005-09-14

    Abstract: This in invention relates to methods for the nucleic acid amplification of multiple variants (strains) of any pathogen present in a sample, and preferably in a sample from a pathogen infected individual. In preferred embodiments, the pathogen is a retrovirus, such as HIV. The amplified pathogen nucleic acid can be used to identify the pathogen variants present in a sample, to quantitate the pathogen present in a sample, and as a nucleic acid vaccine, or in the preparation of antigen presenting cell vaccines. Nucleic acids produced by the methods of the invention or the proteins encoded thereby can be used to transfect/load antigen presenting cells. The loaded antigen presenting cells can then be used as a vaccine for the treatment of pathogen infection. In another embodiment, nucleic acids produced by the methods of the invention can be used directly as nucleic acid vaccines without prior loading into antigen presenting cells.

    Abstract translation: 本发明涉及用于核酸扩增样品中存在的任何病原体的多种变体(菌株)的方法,优选来自病原体感染个体的样品。 在优选的实施方案中,病原体是逆转录病毒,例如HIV。 扩增的病原体核酸可用于鉴定样品中存在的病原体变体,以定量样品中存在的病原体,以及作为核酸疫苗或制备抗原呈递细胞疫苗。 通过本发明的方法产生的核酸或由其编码的蛋白质可用于转染/负载抗原呈递细胞。 然后将负载的抗原呈递细胞用作用于治疗病原体感染的疫苗。 在另一个实施方案中,通过本发明的方法产生的核酸可以直接用作核酸疫苗而不预先加载到抗原呈递细胞中。

    WELLBORE COMMUNICATION SYSTEM AND METHOD
    5.
    发明申请
    WELLBORE COMMUNICATION SYSTEM AND METHOD 审中-公开
    井沟通信系统和方法

    公开(公告)号:US20070168132A1

    公开(公告)日:2007-07-19

    申请号:US11278712

    申请日:2006-04-05

    CPC classification number: E21B47/12

    Abstract: A communication system is used to download data from a downhole tool. The system includes at least one removable memory unit positioned in the downhole tool, at least one surface computer for receiving data from the at least one memory unit and a communication link for transmitting data from the memory unit to the surface computer. The communication link may be a direct, hard-wired, wireless or optical link.

    Abstract translation: 通信系统用于从井下工具下载数据。 该系统包括位于井下工具中的至少一个可移除存储器单元,用于从至少一个存储器单元接收数据的至少一个表面计算机和用于将数据从存储器单元传输到表面计算机的通信链路。 通信链路可以是直接的,硬连线的,无线的或光链路。

    Image server synchronization
    7.
    发明授权
    Image server synchronization 失效
    图像服务器同步

    公开(公告)号:US06938045B2

    公开(公告)日:2005-08-30

    申请号:US10051337

    申请日:2002-01-18

    Abstract: A package of local files are maintained in a first local computing device and a descriptive record of the local files is maintained in a second local computing device. A directory-modified-date parameter within the first local computing device and a file-modified-date parameter in the second local computing device, but updated in accordance with a local clock from the first local computing device, are used to maintain the descriptive record in the second local computing device synchronized with changes to the local files in the first local computing device. Copies of the descriptive record and package of local files are maintained in a remote computing system. A first package-modified-date, PMD, parameter in the second local computing device and a second PMD parameter in the remote computing system are used to maintain the copies in the remote computing system synchronized with those in first and second local computing devices.

    Abstract translation: 一组本地文件被维护在第一本地计算设备中,并且本地文件的描述性记录被维护在第二本地计算设备中。 第一本地计算设备内的目录修改日期参数和第二本地计算设备中的文件修改日期参数,但是根据来自第一本地计算设备的本地时钟更新的参数被用于维护描述性记录 在第二本地计算设备中与第一本地计算设备中的本地文件的改变同步。 在远程计算系统中维护本地文件的描述性记录和包的副本。 使用第二本地计算设备中的第一包修改日期PMD参数和远程计算系统中的第二PMD参数来维护远程计算系统中的副本与第一和第二本地计算设备中的副本同步。

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