-
公开(公告)号:US20110186157A1
公开(公告)日:2011-08-04
申请号:US13046496
申请日:2011-03-11
申请人: Phillip H. PAUL , Jason E. Rehm , Don W. Arnold
发明人: Phillip H. PAUL , Jason E. Rehm , Don W. Arnold
IPC分类号: F15D1/00
CPC分类号: G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要: A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译: 精密流量控制器能够提供小于100微升/分钟的流量,并以规定的方式改变流速,既可预测又可再现,其中流量的精度和精度小于流量的5%。 多个可变压力流体通过单个出口泵送流体。 流量计测量流量,并且控制器将流量与所需流量进行比较,并且如果需要,调整多个可变压力流体供应,使得可变压力流体以期望的流速供应泵流体。 可变压力流体供应可以气动驱动。
-
公开(公告)号:US20110018259A1
公开(公告)日:2011-01-27
申请号:US12874055
申请日:2010-09-01
申请人: Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人: Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
IPC分类号: F16L25/00
CPC分类号: B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要: A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译: 在具有从其突出的细长部件(303)的第一微流体衬底(12)和具有相应管道(261)的第二微流体衬底(22)之间形成接头。 每个基板具有一对对准特征,例如在基板的相对侧中的平面正交表面(13,15; 23,25)或凹槽(141,151; 241,251)。 基板被放置在对准夹具6上,对准夹具6具有与对准特征对应的位置特征(63,65)。 细长部件可以被可压缩垫片40)包围。 基板被推向彼此,使得细长部件进入导管,并且垫圈(如果有的话)被压缩。 只要通过永久的方式将基板保持在必要的位置,或者如果需要可以拆卸的接头,则通过保持基板之间的压力,导致流体密封接合。 描述了新颖的装置和新颖的微流体组件,包括在其侧面具有凹槽的微流体芯片。
-
公开(公告)号:US20100086443A1
公开(公告)日:2010-04-08
申请号:US12625194
申请日:2009-11-24
CPC分类号: G01N30/16 , G01N2030/324 , Y10T436/2575
摘要: A liquid sample is prepared at a preparation site and then processed, e.g. in an HPLC column. The sample is prepared and conveyed to the device at a flow rate which is substantially less than the flow rate through the device. The different flow rates are preferably provided by variable rate working fluid supplies which drive the sample from the preparation site and through the device.
摘要翻译: 在制备部位制备液体样品,然后加工,例如 在HPLC柱中。 制备样品并以基本上小于通过装置的流速的流速将其输送到装置。 不同的流速优选由可变速率的工作流体供应提供,驱动样品从制备部位并通过该装置。
-
公开(公告)号:US07364647B2
公开(公告)日:2008-04-29
申请号:US10198223
申请日:2002-07-17
申请人: Phillip H. Paul , David W. Neyer , Jason E. Rehm
发明人: Phillip H. Paul , David W. Neyer , Jason E. Rehm
CPC分类号: B01F13/0076 , B01D61/18 , B01F5/0682 , B01F5/0692 , B01F15/0201 , B01F15/0232 , B01L3/5023 , B01L3/502707 , B01L3/502753 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0877 , B01L2300/0887 , B01L2400/0418 , F04B19/006 , F04B43/043 , F04B43/06 , F16K99/0001 , F16K99/0025 , F16K99/0049 , G01N27/44791 , G01N30/461 , G01N30/6065 , G01N30/6095 , G01N2030/027 , G01N2030/285 , G01N2030/326 , G01N2030/347 , G01N2030/525 , G01N2030/528 , Y10T156/1046
摘要: A laminated flow device comprises a porous material encapsulated within bonding material. The porous material forms a flow path and the bonding material forms an enclosure surrounding the flow path. Micro-components, such as capillaries, electrodes, reservoirs, bridges, electrokinetic elements, and detectors, can be encapsulated within the device.
摘要翻译: 层压流动装置包括封装在粘合材料内的多孔材料。 多孔材料形成流动路径,并且结合材料形成围绕流动路径的外壳。 诸如毛细管,电极,储存器,桥,电动元件和检测器的微组件可以封装在装置内。
-
公开(公告)号:US08021056B2
公开(公告)日:2011-09-20
申请号:US12874055
申请日:2010-09-01
申请人: Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人: Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
CPC分类号: B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要: A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译: 在具有从其突出的细长部件(303)的第一微流体衬底(12)和具有相应管道(261)的第二微流体衬底(22)之间形成接头。 每个基板具有一对对准特征,例如在基板的相对侧中的平面正交表面(13,15; 23,25)或凹槽(141,151; 241,251)。 基板被放置在对准夹具6上,对准夹具6具有与对准特征对应的位置特征(63,65)。 细长部件可以被可压缩垫片40)包围。 基板被推向彼此,使得细长部件进入导管,并且垫圈(如果有的话)被压缩。 只要通过永久的方式将基板保持在必要的位置,或者如果需要可以拆卸的接头,则通过保持基板之间的压力,导致流体密封接合。 描述了新颖的装置和新颖的微流体组件,包括在其侧面具有凹槽的微流体芯片。
-
公开(公告)号:US07927477B2
公开(公告)日:2011-04-19
申请号:US12334375
申请日:2008-12-12
申请人: Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人: Phillip H. Paul , Jason E. Rehm , Don W. Arnold
IPC分类号: G05B24/04
CPC分类号: G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要: A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译: 精密流量控制器能够提供小于100微升/分钟的流量,并以规定的方式改变流速,既可预测又可再现,其中流量的精度和精度小于流量的5%。 多个可变压力流体通过单个出口泵送流体。 流量计测量流量,并且控制器将流量与所需流量进行比较,并且如果需要,调整多个可变压力流体供应,使得可变压力流体以期望的流速供应泵流体。 可变压力流体供应可以气动驱动。
-
公开(公告)号:US20090090174A1
公开(公告)日:2009-04-09
申请号:US12334375
申请日:2008-12-12
申请人: Phillip H. Paul , Jason E. Rehm , Don W. Arnold
发明人: Phillip H. Paul , Jason E. Rehm , Don W. Arnold
CPC分类号: G01N30/32 , B01D61/56 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , Y10T137/85978 , Y10T137/85986 , Y10T137/86027 , G01N30/34 , G01N2030/285
摘要: A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.
摘要翻译: 精密流量控制器能够提供小于100微升/分钟的流量,并以规定的方式改变流速,既可预测又可再现,其中流量的精度和精度小于流量的5%。 多个可变压力流体通过单个出口泵送流体。 流量计测量流量,并且控制器将流量与所需流量进行比较,并且如果需要,调整多个可变压力流体供应,使得可变压力流体以期望的流速供应泵流体。 可变压力流体供应可以气动驱动。
-
公开(公告)号:US06962658B2
公开(公告)日:2005-11-08
申请号:US10441640
申请日:2003-05-20
CPC分类号: G01N30/16 , G01N2030/324 , Y10T436/2575
摘要: A variable flow rate injector provides accurate, precise, and reproducible injection volumes that have low dispersion. The invention is particularly well-suited for HPLC injection volumes
-
公开(公告)号:US08673144B2
公开(公告)日:2014-03-18
申请号:US12625194
申请日:2009-11-24
IPC分类号: B01D15/08
CPC分类号: G01N30/16 , G01N2030/324 , Y10T436/2575
摘要: A liquid sample is prepared at a preparation site and then processed, e.g. in an HPLC column. The sample is prepared and conveyed to the device at a flow rate which is substantially less than the flow rate through the device. The different flow rates are preferably provided by variable rate working fluid supplies which drive the sample from the preparation site and through the device.
摘要翻译: 在制备部位制备液体样品,然后加工,例如 在HPLC柱中。 制备样品并以基本上小于通过装置的流速的流速将其输送到装置。 不同的流速优选由可变速率的工作流体供应提供,驱动样品从制备部位并通过该装置。
-
公开(公告)号:US07802923B2
公开(公告)日:2010-09-28
申请号:US10599591
申请日:2005-04-01
申请人: Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
发明人: Don W. Arnold , Kenneth R. Hencken , Sammy S. Datwani , Patrick Pak-Ho Leung , Douglas R. Cyr , Jason E. Rehm
CPC分类号: B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2300/0816 , G01N30/6095 , G01N30/6026
摘要: A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13,15; 23,25) or grooves (141,151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.
摘要翻译: 在具有从其突出的细长部件(303)的第一微流体衬底(12)和具有相应管道(261)的第二微流体衬底(22)之间形成接头。 每个基板具有一对对准特征,例如在基板相对侧的平面正交表面(13,15; 23,25)或凹槽(141,151; 241,251)。 基板被放置在对准夹具6上,对准夹具6具有与对准特征对应的位置特征(63,65)。 细长部件可以被可压缩垫片40)包围。 基板被推向彼此,使得细长部件进入导管,并且垫圈(如果有的话)被压缩。 只要通过永久的方式将基板保持在必要的位置,或者如果需要可以拆卸的接头,则通过保持基板之间的压力,导致流体密封接合。 描述了新颖的装置和新颖的微流体组件,包括在其侧面具有凹槽的微流体芯片。
-
-
-
-
-
-
-
-
-