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    Microscale Electrochemical Cell And Methods Incorporating The Cell
    2.
    发明申请
    Microscale Electrochemical Cell And Methods Incorporating The Cell 审中-公开
    微电极电化学电池和结合细胞的方法

    公开(公告)号：US20080182136A1

    公开(公告)日：2008-07-31

    申请号：US11627877

    申请日：2007-01-26

    申请人： Don W. Arnold ,  Guifeng Jiang ,  Nicole E. Hebert

    发明人： Don W. Arnold ,  Guifeng Jiang ,  Nicole E. Hebert

    IPC分类号： H01M14/00 ,  G01N27/26

    CPC分类号： G01N27/403 ,  G01N21/66 ,  G01N21/76 ,  G01N30/7233 ,  G01N30/74

    摘要： An electrochemical cell for processing a sample fluid, has a body with a flow path, the flow path having an inlet and an outlet; a reference electrode in fluid communication with the flow path; a counter electrode in fluid communication with the flow path; a porous working electrode in fluid communication with the flow path, the working electrode having a working electrode material; an electrical connection for the working electrode in electrical contact with the working electrode; and a working electrode section in the flow path. The working electrode is positioned inside the working electrode section. The working electrode section has a volume of from about 1 pL to about 1 μL.

    摘要翻译： 用于处理样品流体的电化学电池具有带流路的主体，所述流路具有入口和出口; 与流路连通的基准电极; 与流路流体连通的对电极; 与所述流路流体连通的多孔工作电极，所述工作电极具有工作电极材料; 用于与工作电极电接触的工作电极的电连接; 和流路中的工作电极部。 工作电极位于工作电极部分内。 工作电极部分具有约1pL至约1μL的体积。

    Method of filling a microchannel separation column
    3.
    发明授权
    Method of filling a microchannel separation column 有权
    填充微通道分离柱的方法

    公开(公告)号：US06444150B1

    公开(公告)日：2002-09-03

    申请号：US09161321

    申请日：1998-09-25

    申请人： Don W. Arnold

    发明人： Don W. Arnold

    IPC分类号： B29C6700

    CPC分类号： G01N30/56 ,  G01N30/6004 ,  G01N30/6095 ,  G01N2030/565

    摘要： A method for packing a stationary phase into a small diameter fluid passageway or flow channel. Capillary action is employed to distribute a stationary phase uniformly along both the length and diameter of the flow channel. The method disclosed here: 1) eliminates the need for high pressure pumps and fittings and the safety hazards associated therewith; 2) allows the use of readily available commercial microparticles, either coated or uncoated, as the stationary phase; 3) provides for different types of particles, different particle sizes, and different particle size distributions to be packed in sequence, or simultaneously; 4) eliminates the need for plugging the flow channel prior to adding the stationary phase to retain the packing particles; and 5) many capillaries can be filled simultaneously.

    摘要翻译： 将固定相包装到小直径流体通道或流动通道中的方法。 采用毛细管作用来均匀地沿流动通道的长度和直径分布固定相。 这里公开的方法：1）消除了对高压泵和配件的需要以及与之相关的安全隐患; 2）允许使用易于获得的商业微粒，无论是涂覆的还是未涂覆的，作为固定相; 3）提供按顺序或同时包装的不同类型的颗粒，不同的颗粒尺寸和不同的颗粒尺寸分布; 4）消除了在添加固定相以保持填料颗粒之前堵塞流动通道的需要; 和5）可以同时填充许多毛细血管。

    Method for eliminating gas blocking in electrokinetic pumping systems
    4.
    发明授权
    Method for eliminating gas blocking in electrokinetic pumping systems 有权
    在动力泵送系统中消除气体阻塞的方法

    公开(公告)号：US06287440B1

    公开(公告)日：2001-09-11

    申请号：US09336535

    申请日：1999-06-18

    申请人： Don W. Arnold ,  Phillip H. Paul ,  Joseph S. Schoeniger

    发明人： Don W. Arnold ,  Phillip H. Paul ,  Joseph S. Schoeniger

    IPC分类号： B01D5702

    CPC分类号： F04B53/06 ,  F04B19/006

    摘要： A method for eliminating gas bubble blockage of current flow during operation of an electrokinetic pump. By making use of the ability to modify the surface charge on the porous dielectric medium used in electrokinetic pumps, it becomes possible to place electrodes away from the pressurized region of the electrokinetic pump. While gas is still generated at the electrodes they are situated such that the generated gas can escape into a larger buffer reservoir and not into the high pressure region of the pump where the gas bubbles can interrupt current flow. Various combinations of porous dielectric materials and ionic conductors can be used to create pumps that have desirable electrical, material handling, and flow attributes.

    摘要翻译： 一种在电动泵运行过程中消除气流阻塞电流的方法。 通过利用在电动泵中使用的多孔介电介质上的表面电荷的修饰能力，可以将电极放置在电动泵的加压区域之外。 虽然在电极处仍然产生气体，但是它们被定位成使得所产生的气体可以逸出到更大的缓冲容器中，而不会进入泵的高压区域，在该高压区域中气泡可以中断电流。 可以使用多孔介电材料和离子导体的各种组合来产生具有期望的电气，材料处理和流动属性的泵。

    Electrokinetic high pressure hydraulic system
    5.
    发明授权
    Electrokinetic high pressure hydraulic system 有权
    电动高压液压系统

    公开(公告)号：US06277257B1

    公开(公告)日：2001-08-21

    申请号：US09271687

    申请日：1999-03-18

    申请人： Phillip H. Paul ,  David J. Rakestraw ,  Don W. Arnold ,  Kenneth R. Hencken ,  Joseph S. Schoeniger ,  David W. Neyer

    发明人： Phillip H. Paul ,  David J. Rakestraw ,  Don W. Arnold ,  Kenneth R. Hencken ,  Joseph S. Schoeniger ,  David W. Neyer

    IPC分类号： B01D6144

    CPC分类号： G01N30/32 ,  F04B19/006 ,  G01N2030/285 ,  G01N2030/326

    摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.

    摘要翻译： 一种电动高压液压泵，用于在毛细管系统中操纵流体。 泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体 特别是在毛细管系统（Microsystems）中通常流动。 本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及 现场可携带性。 通过控制施加到电动泵的电压来实现压力和溶剂流​​速的控制。

    Microfluidic connections
    6.
    发明授权
    Microfluidic connections 有权
    微流体连接

    公开(公告)号：US08021056B2

    公开(公告)日：2011-09-20

    申请号：US12874055

    申请日：2010-09-01

    申请人： Don W. Arnold ,  Kenneth R. Hencken ,  Sammy S. Datwani ,  Patrick Pak-Ho Leung ,  Douglas R. Cyr ,  Jason E. Rehm

    发明人： Don W. Arnold ,  Kenneth R. Hencken ,  Sammy S. Datwani ,  Patrick Pak-Ho Leung ,  Douglas R. Cyr ,  Jason E. Rehm

    IPC分类号： G02B6/36 ,  G02B6/38

    CPC分类号： B01L3/502715 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/0816 ,  G01N30/6095 ,  G01N30/6026

    摘要： A junction is made between a first microfluidic substrate (12) having an elongate component (303) protruding from it and a second microfluidic substrate (22) having a corresponding conduit (261). Each of the substrates has a pair of alignment features, for example planar orthogonal surfaces (13, 15; 23, 25) or grooves (141, 151; 241, 251) in opposite sides of the substrate. The substrates are placed on an alignment jig 6 having location features (63, 65) corresponding to the alignment features. The elongate component can be surrounded by a compressible gasket 40). The substrates are pushed towards each other so that the elongate component enters the conduit and the gasket, if any, is compressed. A fluid-tight junction results so long as the substrates are maintained in the necessary position, either by permanent means, or, if a junction which can be disassembled is needed, by maintaining pressure between the substrates. Novel apparatus and novel microfluidic assemblies, including microfluidic chips having grooves in their sides, are described.

    摘要翻译： 在具有从其突出的细长部件（303）的第一微流体衬底（12）和具有相应管道（261）的第二微流体衬底（22）之间形成接头。 每个基板具有一对对准特征，例如在基板的相对侧中的平面正交表面（13,15; 23,25）或凹槽（141,151; 241,251）。 基板被放置在对准夹具6上，对准夹具6具有与对准特征对应的位置特征（63,65）。 细长部件可以被可压缩垫片40）包围。 基板被推向彼此，使得细长部件进入导管，并且垫圈（如果有的话）被压缩。 只要通过永久的方式将基板保持在必要的位置，或者如果需要可以拆卸的接头，则通过保持基板之间的压力，导致流体密封接合。 描述了新颖的装置和新颖的微流体组件，包括在其侧面具有凹槽的微流体芯片。

    Precision flow control system
    7.
    发明授权
    Precision flow control system 有权
    精密流量控制系统

    公开(公告)号：US07927477B2

    公开(公告)日：2011-04-19

    申请号：US12334375

    申请日：2008-12-12

    申请人： Phillip H. Paul ,  Jason E. Rehm ,  Don W. Arnold

    发明人： Phillip H. Paul ,  Jason E. Rehm ,  Don W. Arnold

    IPC分类号： G05B24/04

    CPC分类号： G01N30/32 ,  B01D61/56 ,  G01N2030/324 ,  G01N2030/326 ,  G05D7/0694 ,  G05D11/132 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86027 ,  G01N30/34 ,  G01N2030/285

    摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.

    摘要翻译： 精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。 多个可变压力流体通过单个出口泵送流体。 流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。 可变压力流体供应可以气动驱动。

    Precision Flow Control System
    9.
    发明申请
    Precision Flow Control System 有权
    精密流量控制系统

    公开(公告)号：US20090090174A1

    公开(公告)日：2009-04-09

    申请号：US12334375

    申请日：2008-12-12

    申请人： Phillip H. Paul ,  Jason E. Rehm ,  Don W. Arnold

    发明人： Phillip H. Paul ,  Jason E. Rehm ,  Don W. Arnold

    IPC分类号： G01N30/32 ,  B01D35/14 ,  G05D7/06

    CPC分类号： G01N30/32 ,  B01D61/56 ,  G01N2030/324 ,  G01N2030/326 ,  G05D7/0694 ,  G05D11/132 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86027 ,  G01N30/34 ,  G01N2030/285

    摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.

    摘要翻译： 精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。 多个可变压力流体通过单个出口泵送流体。 流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。 可变压力流体供应可以气动驱动。

    Precision flow control system
    10.
    发明授权
    Precision flow control system 有权
    精密流量控制系统

    公开(公告)号：US08685218B2

    公开(公告)日：2014-04-01

    申请号：US13046496

    申请日：2011-03-11

    申请人： Phillip H. Paul ,  Jason E. Rehm ,  Don W. Arnold

    发明人： Phillip H. Paul ,  Jason E. Rehm ,  Don W. Arnold

    IPC分类号： G05B24/04

    CPC分类号： G01N30/32 ,  B01D61/56 ,  G01N2030/324 ,  G01N2030/326 ,  G05D7/0694 ,  G05D11/132 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86027 ,  G01N30/34 ,  G01N2030/285

    摘要： A precision flow controller is capable of providing a flow rate less than 100 microliters/minute and varying the flow rate in a prescribed manner that is both predictable and reproducible where the accuracy and precision of the flowrate is less than 5% of the flow rate. A plurality of variable pressure fluid supplies pump fluid through a single outlet. Flowmeters measure the flow rates and a controller compares the flow rates to desired flowrates and, if necessary, adjusts the plurality of variable pressure fluid supplies so that the variable pressure fluid supplies pump fluid at the desired flow rate. The variable pressure fluid supplies can be pneumatically driven.

    摘要翻译： 精密流量控制器能够提供小于100微升/分钟的流量，并以规定的方式改变流速，既可预测又可再现，其中流量的精度和精度小于流量的5％。 多个可变压力流体通过单个出口泵送流体。 流量计测量流量，并且控制器将流量与所需流量进行比较，并且如果需要，调整多个可变压力流体供应，使得可变压力流体以期望的流速供应泵流体。 可变压力流体供应可以气动驱动。