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公开(公告)号：US20110046238A1
公开(公告)日：2011-02-24
申请号：US12546284
申请日：2009-08-24
申请人： Bruce A. Keiser , Timothy S. Keizer , Brett M. Showalter , Tiffany Bohnsack , James H. Adair , Mylisa Parette , Amy Knupp , Andrei S. Zelenev , Jason R. Burney
发明人： Bruce A. Keiser , Timothy S. Keizer , Brett M. Showalter , Tiffany Bohnsack , James H. Adair , Mylisa Parette , Amy Knupp , Andrei S. Zelenev , Jason R. Burney
CPC分类号： A01N25/08 , D06P1/67366
摘要： The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers. As such, the particle can be used in a variety of applications including any of a variety of high temperature, at acidic, neutral, or basic pH, or pressure environments. The carrier particles have applications as diverse as papermaking, water treatment, chemical tracing, personal care, microbiological control, oil recovery, delivery of polymers, for example.
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公开(公告)号：US06214756B1
公开(公告)日：2001-04-10
申请号：US08874798
申请日：1997-06-13
IPC分类号： C04B3546
CPC分类号： C04B35/63488 , C04B35/581 , C04B35/584 , C04B35/632 , C04B35/634 , C04B35/63444
摘要： A uniform suspension of ceramic powder and method for making the same. The suspension is prepared by mixing finely divided ceramic powder in an aqueous carrier fluid, combining with a dispersing agent, and alternatively, an organic binder when forming a slip. The ceramic powder has an average particle size of about 0.5 micron or less and is present in the suspension in a loading of up to 30% by volume of the total solids in suspension. A passivating agent is present in the carrier fluid in an amount of 0.5 to 5% by weight of the ceramic powder present for suspension and slip respectively. After the addition of a dispersant, the suspension has a Bingham yield point of less than 230 dynes/cm2 and an apparent viscosity of less than 3000 cps. A green layer produced from the slip exhibits a pore size of less than 0.5 micron.
摘要翻译： 陶瓷粉末的均匀悬浮液及其制造方法。 通过将细分散的陶瓷粉末混合在水性载体流体中，与分散剂组合，或者在形成滑移时与有机粘合剂混合来制备悬浮液。 陶瓷粉末具有约0.5微米或更小的平均粒度，并且以悬浮液中总固体的至多30体积％的负载量存在于悬浮液中。 载体流体中的钝化剂分别以用于悬浮和滑动的陶瓷粉末的0.5至5重量％的量存在。 添加分散剂后，悬浮液的Bingham屈服点小于230达因/ cm2，表观粘度小于3000cps。 由滑动层产生的绿色层表现出小于0.5微米的孔径。
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公开(公告)号：US5501877A
公开(公告)日：1996-03-26
申请号：US308156
申请日：1994-09-19
摘要： A method for creating a patterned thin film of a high surface energy material on a substrate comprising the steps of creating a photomask pattern on the substrate using photolithography, providing an oppositely charged surface on the substrate and photomask, if such does not exist, from that of particles of the high surface energy material, removing the photomask and exposing the substrate to an aqueous colloidal suspension of particles composed of the high surface energy material to adsorb seed particles onto the surface of the substrate, or removing the photomask after adsorbing seed particles to the surface, and then depositing a uniform thin film of the high surface energy material by chemical vapor deposition onto the seeded substrate.
摘要翻译： 一种用于在衬底上形成高表面能材料的图案化薄膜的方法，包括以下步骤：使用光刻法在衬底上产生光掩模图案，在衬底上提供相反电荷的表面和光掩模（如果不存在） 的高表面能材料的颗粒，去除光掩模，并将基底暴露于由高表面能材料构成的颗粒的水性胶体悬浮液中，以将种子颗粒吸附到基材的表面上，或者在将种子颗粒吸附到颗粒之后去除光掩模 然后通过化学气相沉积将高表面能材料的均匀薄膜沉积到接种的基底上。
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4.发明授权
公开(公告)号：US5492769A
公开(公告)日：1996-02-20
申请号：US948354
申请日：1992-09-17
CPC分类号： C04B41/4545 , B05D5/02 , C03C17/007 , C08J7/06 , C23C26/00 , C23C26/02 , C03C2217/42 , C04B2111/00362 , Y10T428/12056
摘要： A method is provided for improving the scratch or surface wear resistance of substrates by embedding discrete, hard particles within the surface layer of the substrate. Discrete, hard particles are applied to the substrate surface and then embedded within and bonded to the surface layer of the substrate by softening the substrate surface layer by either thermal or solvent means. Suitable substrate materials include thermoplastics, thermoset plastics, polymers, glass, soft metals, and composites. Suitable hard particles include diamond, silicon dioxide, aluminum oxide, cubic boron nitride, boron carbide, silicon carbide, silicon nitride, tantalum carbide, titanium carbide, titanium nitride, tungsten carbide, and zirconia alloys containing at least one phase stabilization additive selected from the group yttrium, hafnium, calcium, magnesium, and cesium. Scratch resistant substrates or articles having discrete, hard particles embedded within the surface layer of the substrate or article are also provided. These substrates or articles essentially have the surface wear characteristics of the hard particles or material embedded within the surface layer. Thus, it is possible to prepare plastic materials or articles having significantly improved scratch or surface wear resistance without significantly increasing the weight or external dimensions of the plastic materials or articles.
摘要翻译： 提供了一种通过在分散的硬质颗粒内嵌入衬底的表面层来改善衬底的划伤或表面耐磨性的方法。 将离散的硬颗粒施加到基材表面，然后通过热或溶剂方法软化基材表面层，然后嵌入基材的表面层中并结合到基材的表面层。 合适的基材包括热塑性塑料，热固性塑料，聚合物，玻璃，软金属和复合材料。 合适的硬颗粒包括金刚石，二氧化硅，氧化铝，立方氮化硼，碳化硼，碳化硅，氮化硅，碳化钽，碳化钛，氮化钛，碳化钨和含有至少一种相稳定添加剂的氧化锆合金， 钇，铪，钙，镁和铯。 还提供了具有嵌入在基材或制品的表面层内的分散的硬颗粒的耐刮擦基材或制品。 这些基材或制品基本上具有嵌入在表面层内的硬质颗粒或材料的表面磨损特性。 因此，可以制备具有显着改善的耐擦伤性或表面耐磨性的塑料材料或制品，而不显着增加塑料材料或制品的重量或外部尺寸。
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5.发明授权In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles 有权通过封装在磷酸钙纳米粒子中的近红外线的体内光动力治疗癌症公开(公告)号：US08771741B2
公开(公告)日：2014-07-08
申请号：US12657556
申请日：2010-01-22
申请人： James H. Adair , Mark Kester , Erhan I. Altinoglu , Brian M. Barth , Timothy J. Russin , James M. D. Kaiser , Thomas T. Morgan , Karen L. Eklund
发明人： James H. Adair , Mark Kester , Peter C. Eklund , Erhan I. Altinoglu , Brian M. Barth , Timothy J. Russin , James M. D. Kaiser , Thomas T. Morgan
IPC分类号： A61K9/14
CPC分类号： A61K41/0057 , A61K9/51 , A61K47/6921 , A61K47/6923
摘要： Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.
摘要翻译： 描述了纳米包封的光敏剂及其在治疗肿瘤和/或成像中的用途。 优选地，将光敏剂包封在磷酸钙纳米颗粒（CPNP）中。 将PS封装在CPNP中增加PS的半衰期，增加PS进入靶细胞组织的吸收，增加PS的光稳定性，增加PS的光效，增加PS的体内保留或组合 最终使其成为用于光动力疗法，成像靶组织，血管或肿瘤，和/或检测或定位肿瘤的高效药物。
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公开(公告)号：US20110046241A1
公开(公告)日：2011-02-24
申请号：US12546369
申请日：2009-08-24
CPC分类号： D21H19/38 , C02F1/50 , C02F2303/08
摘要： The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers. As such, the particle can be used in a variety of applications including any of a variety of high temperature, at acidic, neutral, or basic pH, or pressure environments. The carrier particles have applications as diverse as papermaking, water treatment, chemical tracing, personal care, microbiological control, oil recovery, delivery of polymers, for example.
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7.发明申请In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles 有权通过封装在磷酸钙纳米粒子中的近红外线的体内光动力治疗癌症公开(公告)号：US20100247436A1
公开(公告)日：2010-09-30
申请号：US12657556
申请日：2010-01-22
申请人： James H. Adair , Mark Kester , Peter C. Eklund , Karen L. Eklund , Erhan Altinoglu , Brian M. Barth , Timothy J. Russin , James M.D. Kaiser , Thomas T. Morgan
发明人： James H. Adair , Mark Kester , Peter C. Eklund , Karen L. Eklund , Erhan Altinoglu , Brian M. Barth , Timothy J. Russin , James M.D. Kaiser , Thomas T. Morgan
CPC分类号： A61K41/0057 , A61K9/51 , A61K47/6921 , A61K47/6923
摘要： Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.
摘要翻译： 描述了纳米包封的光敏剂及其在治疗肿瘤和/或成像中的用途。 优选地，将光敏剂包封在磷酸钙纳米颗粒（CPNP）中。 将PS封装在CPNP中增加PS的半衰期，增加PS进入靶细胞组织的吸收，增加PS的光稳定性，增加PS的光效，增加PS的体内保留或组合 最终使其成为用于光动力疗法，成像靶组织，血管或肿瘤，和/或检测或定位肿瘤的高效药物。
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8.发明授权Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo 有权钙磷硅酸盐纳米颗粒的生物缀合用于体内细胞的选择性靶向公开(公告)号：US09149544B2
公开(公告)日：2015-10-06
申请号：US12941719
申请日：2010-11-08
申请人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
发明人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
CPC分类号： A61K49/0093 , A61K41/0057 , A61K47/48861 , A61K47/6923 , A61K49/0034 , A61K49/0043
摘要： Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要翻译： 非聚集的可再吸收的磷酸钙纳米粒子（CPNP）被生物缀合成靶向特定细胞特异性的分子。 CPNPs在正常生理pH下是稳定的颗粒。 化疗和成像剂可以与CPNP整体形成，使得它们在CPNP内被分隔。 以这种方式，保护试剂免于在正常生理pH下与环境的相互作用。 然而，一旦CPNP被摄取，在细胞内的pH值下，CPNP溶解释放药剂。 因此，化学治疗或显像剂被递送到特定的细胞并允许这些细胞的治疗和/或成像。 使用生物共轭CPNP都限制了全身暴露于药剂的量，并将更高浓度的药剂递送至细胞。 生物缀合CPNP的方法和原理通过乳腺癌，胰腺癌和白血病靶向分子的生物缀合的实例来教导。
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公开(公告)号：US08071132B2
公开(公告)日：2011-12-06
申请号：US11142913
申请日：2005-06-01
申请人： James H. Adair , Sarah M. Rouse , Jun Wang , Mark Kester , Christopher Siedlecki , William B. White , Erwin Vogler , Alan Snyder , Carlo G. Pantano , Victor Ruiz-Velasco , Lawrence Sinoway
发明人： James H. Adair , Sarah M. Rouse , Jun Wang , Mark Kester , Christopher Siedlecki , William B. White , Erwin Vogler , Alan Snyder , Carlo G. Pantano , Victor Ruiz-Velasco , Lawrence Sinoway
IPC分类号： A61K9/14
CPC分类号： A61K49/0041 , A61K47/6923 , A61K47/6929 , A61K49/0093 , B01J13/02 , B82Y5/00 , B82Y30/00 , Y10T428/2982 , Y10T428/2984 , Y10T428/2989 , Y10T428/2991 , Y10T428/2995
摘要： The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.
摘要翻译： 本发明提供了一种用于合成非聚集的，高度分散的，稳定的核/壳纳米复合材料颗粒的方法，其包括制备含有纳米复合颗粒的反胶束微乳液，用硅烷偶联剂处理微乳液，破碎微乳液以形成悬浮液 该纳米复合颗粒通过向微乳液中加入酸/醇溶液，将纳米复合材料颗粒的悬浮液保持在约6和7之间的pH，同时洗涤和分散纳米复合颗粒的悬浮液，优选用尺寸排阻HPLC系统修饰为 确保纳米复合材料颗粒的团聚。 纳米复合材料颗粒的一次粒径可以在约1至100nm之间，优选约10至50nm，更优选约10至20nm，最优选约20nm的范围内。
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公开(公告)号：US20100331431A1
公开(公告)日：2010-12-30
申请号：US12495109
申请日：2009-06-30
CPC分类号： C01B33/18 , B82Y30/00 , C01B33/146 , C01B33/149 , C01P2002/84 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/12
摘要： The present invention relates to a method for forming a silica-based particle or composite consisting of a silica-based material, an active, with or without a surface modification, and the related composition. The silica-based particle is illustrated by the formula (SiO2)x(OH)yRzSt, whereby R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, and water soluble agents and, optionally, a surface modifier, S, which may be either organic, polymeric, or inorganic. Examples of a surface modifying material are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers. As such, the particle can be used in a variety of applications including any of a variety of high temperature, at acidic, neutral, or basic pH, or pressure environments. The composites have applications as diverse as papermaking, water treatment, chemical tracing, personal care, microbiological control, and delivery of polymers, for example. With regard to papermaking, the particle provides retention and drainage performance while delivering whitener, or OBA, other functional additives and serves an additive tracker.
摘要翻译： 本发明涉及一种由二氧化硅基材料，活性物质，有或没有表面改性剂形成的二氧化硅基颗粒或复合材料的形成方法及相关组合物。 二氧化硅基颗粒由式（SiO 2）x（OH）y R z St表示，其中R是活性或活性物质，例如有机或无机分子，其包括标记，胺，硫醇，环氧化物，有机硅氧烷，有机硅烷和水溶性 试剂和任选的表面改性剂S，其可以是有机的，聚合的或无机的。 表面改性材料的实例是铝和硼的无机盐或有机材料如有机硅烷或低分子量聚合物。 因此，颗粒可以用于各种应用，包括各种高温，酸性，中性或碱性pH或压力环境中的任何一种。 复合材料具有例如造纸，水处理，化学追踪，个人护理，微生物控制和聚合物递送等多种应用。 关于造纸，颗粒提供保留和排水性能，同时提供增白剂或OBA其他功能性添加剂，并提供添加剂追踪器。
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