公开(公告)号：US20140308691A1

公开(公告)日：2014-10-16

申请号：US14124958

申请日：2012-06-11

Applicant: Jakob Weber ,  Lara Hasan ,  Thomas Jermann ,  Michel-Angelo Sciotti ,  Daniel Gygax ,  Andre Scholer

Inventor： Jakob Weber ,  Lara Hasan ,  Thomas Jermann ,  Michel-Angelo Sciotti ,  Daniel Gygax ,  Andre Scholer

IPC: C12Q1/48 ,  C12Q1/26 ,  C12Q1/28

CPC classification number: C12Q1/48 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/527 ,  G01N33/82 ,  G01N2333/90238 ,  G01N2333/988

Abstract: The invention relates to methods for the determination of vitamin B6 in samples as well as to reagent compositions for assaying a sample for vitamin B6 and to a test kit suitable for carrying out the methods according to the present invention. Further, the invention relates to the use of such methods for the application to different analyzing devices such as micro-titer plate readers and fully automated clinical chemistry analyzers (autoanalyzers).

Abstract translation: 本发明涉及用于测定样品中维生素B6的方法以及用于测定维生素B6样品的试剂组合物以及适用于实施本发明方法的测试试剂盒。 此外，本发明涉及这种方法用于不同分析装置的应用，例如微量滴定板读数器和全自动临床化学分析仪（自动分析仪）。

公开(公告)号：US20100221756A1

公开(公告)日：2010-09-02

申请号：US12677402

申请日：2008-09-11

Applicant: Jean Sainte-Laudy ,  Michael Schneider ,  Jakob Weber

Inventor： Jean Sainte-Laudy ,  Michael Schneider ,  Jakob Weber

IPC: G01N33/53

CPC classification number: G01N33/5047 ,  G01N33/5091 ,  G01N2800/24

Abstract: The invention pertains to a method for the determination of basophil activation induced by a test substance by flow cytometric measurement of the changes of the mean or median fluorescence intensities (WI) of the basophilic FcεRI receptor present on the cell surface of basophils (MFI-FcεRI) and/or the IgE antibodies bound to the FcεRI receptor (MFI-IgE), and the CD63 antigen exposed on the cell surface of basophils after their activation (MFI-CD63), by means of a mixture of anti-CD63, anti-FcεRI or anti-IgE, and anti-CCR3 antibodies each labelled with a distinct fluorophore, of which at least one antibody acts as a basophil selection marker and at least two antibodies act as basophil activation markers, and bringing the mean fluorescence intensities of the activation markers in correlation to obtain an Activation Index. These methods combining the measurement of an early (such as IgE, FcεRI or CD203c) and a late basophil activation marker (such as CD63), respectively, provide a markedly improved clinical sensitivity in allergy diagnosis over existing methods which consider only one activation marker, such as CD203c or CD63, expressed in percentage of basophil activation. It is also an aspect of the present invention to provide an ex-vivo allergy provocation test comprising the above-mentioned flow cytometric measurement and analysis of the results as well as a test kit for carrying out the test in-vitro.

Abstract translation: 本发明涉及一种用于通过流式细胞术测量嗜碱性粒细胞细胞表面上存在的嗜碱性FcγR受体的平均值或中值荧光强度（WI）的变化来测定受试物质诱导的嗜碱性粒细胞活化的方法（MFI -Fc＆amp; RI）和/或结合至FcγRI受体（MFI-IgE）的IgE抗体和暴露于嗜碱性粒细胞活化后的细胞表面上的CD63抗原（MFI-CD63），通过 每个用不同荧光团标记的至少一种抗体作为嗜碱性粒细胞选择标记，并且至少两种抗体作为嗜碱性粒细胞活化标记，并且所述抗CD3抗体具有抗CD63抗体，抗Fc抗体或抗IgE抗体， 使激活标记的平均荧光强度相关，获得激活指数。 结合早期测量（如IgE，Fc和egr RI或CD203c）和晚期嗜碱性粒细胞活化标记（如CD63）的这些方法分别提供了对仅考虑一种激活的现有方法的过敏诊断中临床敏感性的显着提高 标记物，如CD203c或CD63，以嗜碱性粒细胞活化的百分比表示。 本发明的另一方面是提供一种包含上述流式细胞术测量和结果分析的离体过敏激发试验以及用于在体外进行试验的测试试剂盒。

公开(公告)号：US4425944A

公开(公告)日：1984-01-17

申请号：US320869

申请日：1981-11-13

Applicant: Frederik E. Heuckelbach ,  Robert Weber ,  Jakob Weber

Inventor： Frederik E. Heuckelbach ,  Robert Weber ,  Jakob Weber

IPC: F28F11/02 ,  F16L55/10 ,  F16L55/12

CPC classification number: F28F11/02

Abstract: Repair plug for sealing heat exchanger tubes, including a closure plug part being tightly connectable to a heat exchanger tube and having an end for insertion into the heat exchanger tube, and a polisher plug part disposed on the insertion end of the closure plug part axially in front of the insertion end in insertion direction thereof forming a single structural unit with the closure plug part, the polisher plug part remaining in the sealed heat exchanger tube after completing the tight connection.

Abstract translation: 用于密封热交换器管的修理插头，包括封闭插头部分，其紧密连接到热交换器管并且具有用于插入热交换器管的端部;以及抛光器插塞部分，其轴向地设置在封闭插塞部件的插入端 插入端的前端在插入方向上形成具有封闭插塞部分的单个结构单元，在完成紧密连接之后，抛光器插头部分保留在密封的热交换器管中。

公开(公告)号：US5749470A

公开(公告)日：1998-05-12

申请号：US569717

申请日：1995-12-08

Applicant: Hermann Operschall ,  Jakob Weber ,  Klaus-Alfred Steiner ,  Stefan Ring

Inventor： Hermann Operschall ,  Jakob Weber ,  Klaus-Alfred Steiner ,  Stefan Ring

IPC: G21F9/28 ,  B24C9/00 ,  G21F9/00 ,  G21F9/30 ,  B03B9/00

CPC classification number: G21F9/001 ,  B24C9/00

Abstract: An installation for decontaminating a radioactively contaminated surface with a dry mechanical abrasive includes an extractor for suction extraction of an extraction gas together with an abrasive/dust mixture produced during blasting. A separator separates the abrasive/dust mixture aspirated by the extractor into a dust fraction and a re-usable abrasive fraction. A storage bin is connected between the extractor and the separator. The storage bin includes a filter device having a filter for filtering the extraction gas flowing through the storage bin to the extractor, and a blowoff line to be connected to the filter device for blowing off the filter.

Abstract translation: 一种用干式机械磨料对放射性污染表面进行净化的设备包括一个提取器，用于抽吸气体抽吸与喷砂过程中产生的磨料/粉尘混合物。 分离器将由萃取器吸出的磨料/粉尘混合物分离成灰尘级分和可重复使用的磨料部分。 存储箱连接在提取器和分离器之间。 存储箱包括具有过滤器的过滤装置，该过滤器用于将流过储存箱的萃取气体过滤到萃取器;以及吹扫管线，连接到过滤装置以吹出过滤器。

公开(公告)号：US4645581A

公开(公告)日：1987-02-24

申请号：US766773

申请日：1985-08-16

Applicant: Ludwig Voggenthaler ,  Hermann Operschall ,  Jakob Weber

Inventor： Ludwig Voggenthaler ,  Hermann Operschall ,  Jakob Weber

IPC: C25F3/16 ,  C25F7/00 ,  F22B37/00 ,  G21F9/00 ,  C25D17/00

CPC classification number: C25F7/00 ,  C25F3/16 ,  F22B37/003 ,  G21F9/004

Abstract: Method for electropolishing the inner surface of an U-shaped heat exchanger tube with an electrode connected to a negative pole of a d-c voltage source, the electrode being slidable into the heat exchanger tube and withdrawable out of the tube by a pulling member, and with a pump connected to an electrolyte tank for feeding electrolyte into the heat exchanger tube, which comprises inserting into two chambers, respectively, formed in a bottom hemispherical shell of a heat exchanger, respective manipulators formed with jibs for positioning tube probes by remote control into end openings of U-shaped heat exchanger tubes disposed in the heat exchanger and opening into the chambers; pressing by the manipulators respective adapters, which are connected to hose connectors and are carried at respective free ends of the manipulator jibs, to the end openings of the heat exchanger tubes through the intermediary of respective seals so as to align in each of the chambers the end opening of one of the U-shaped heat exchanger tubes with respective hoses connected thereto by the hose connectors; inserting an electrode by a thrust cable through one of the hoses and into the respective heat exchanger tube up to a given location therein; pumping electrolyte through one of the hoses into the respective heat exchanger tube and conducting it from the other hose into a collecting tray; electrically energizing the electrode and withdrawing it slowly from the respective heat exchanger tube while the electrode remains energized; and thereafter removing the electrolyte from the respective heat exchanger tube.

Abstract translation: 用直流电压源的负极连接的电极对U形热交换器管的内表面进行电解抛光的方法，该电极可滑动到热交换器管中，并通过拉动构件从管可抽出， 连接到用于将电解质进料到热交换器管中的电解质罐的泵，其包括分别插入形成在热交换器的底部半球形壳体中的两个室中，各个操作器形成有用于通过遥控器将管探针定位成端部 U形热交换器管的开口设置在热交换器中并且通向腔室; 通过操纵器相应的适配器，其通过相应的密封件相互连接到软管连接器并且在机械手臂的相应自由端承载到热交换器管的端部开口，以便在每个室中对准 通过软管连接器使相应的软管连接在一起的U形热交换器管之一的端部开口; 通过推力电缆将电极穿过其中一根软管并进入相应的热交换器管，直到其中的给定位置; 将电解液通过其中一根软管泵送到相应的热交换器管中，并将其从另一软管导入收集盘; 当电极保持通电时，使电极电激励并从相应的热交换器管缓慢地将其取出; 然后从相应的热交换器管中除去电解质。

公开(公告)号：US4336104A

公开(公告)日：1982-06-22

申请号：US062067

申请日：1979-07-30

Applicant: Dietgar Figlhuber ,  Johannes Gallwas ,  Robert Weber ,  Jakob Weber

Inventor： Dietgar Figlhuber ,  Johannes Gallwas ,  Robert Weber ,  Jakob Weber

IPC: G01N29/04 ,  G21C17/003 ,  G21C17/007 ,  G21C17/00

CPC classification number: G21C17/007

Abstract: Inspection and testing device for the bottoms of reactor pressure vessels, including an insulation layer and a shielding layer enclosing the pressure vessel, a track fitted to the bottom of the pressure vessel having a first part fixed to the bottom of the pressure vessel and a second part detachable from the first part and passing through the insulation and shielding layers, the second part having a substantially horizontal end region disposed outside the shielding layer, and including a testing and inspection device connected to the track for inspecting and testing the bottom of the pressure vessel.

Abstract translation: 用于反应堆压力容器的底部的检查和测试装置，包括绝缘层和围绕压力容器的屏蔽层，安装在压力容器底部的轨道，其具有固定到压力容器底部的第一部分和第二部分 部分可从第一部分拆卸并穿过绝缘和屏蔽层，第二部分具有设置在屏蔽层外侧的基本水平的端部区域，并且包括连接到轨道的测试和检查装置，用于检查和测试底部的压力 船只。

公开(公告)号：US09574221B2

公开(公告)日：2017-02-21

申请号：US14124958

申请日：2012-06-11

Applicant: Jakob Weber ,  Lara Hasan ,  Thomas Jermann ,  Michel-Angelo Sciotti ,  Daniel Gygax ,  Andre Scholer

Inventor： Jakob Weber ,  Lara Hasan ,  Thomas Jermann ,  Michel-Angelo Sciotti ,  Daniel Gygax ,  Andre Scholer

IPC: C12Q1/48 ,  C12Q1/28 ,  G01N33/82 ,  C12Q1/527 ,  C12Q1/26

CPC classification number: C12Q1/48 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/527 ,  G01N33/82 ,  G01N2333/90238 ,  G01N2333/988

Abstract: The invention relates to methods for the determination of vitamin B6 in samples as well as to reagent compositions for assaying a sample for vitamin B6 and to a test kit suitable for carrying out the methods according to the present invention. Further, the invention relates to the use of such methods for the application to different analyzing devices such as micro-titer plate readers and fully automated clinical chemistry analyzers (autoanalyzers).

Abstract translation: 本发明涉及用于测定样品中维生素B6的方法以及用于测定维生素B6样品的试剂组合物以及适用于实施本发明方法的测试试剂盒。 此外，本发明涉及这种方法用于不同分析装置的应用，例如微量滴定板读数器和全自动临床化学分析仪（自动分析仪）。

公开(公告)号：US4572284A

公开(公告)日：1986-02-25

申请号：US460859

申请日：1983-01-25

Applicant: Erich Katscher ,  Johannes Stoss ,  Robert Weber ,  Dieter Zoberlein ,  Jakob Weber ,  Josef Forster

Inventor： Erich Katscher ,  Johannes Stoss ,  Robert Weber ,  Dieter Zoberlein ,  Jakob Weber ,  Josef Forster

IPC: F22B37/48 ,  F22B37/54 ,  F28G15/00

CPC classification number: F22B37/54 ,  F22B37/483 ,  F28G15/00

Abstract: Tube lane manipulator for the high-pressure blowdown of heat exchangers having tubes being spaced apart by a given pitch forming tube lanes therebetween with tubes on opposite sides and having closeable servicing openings formed therein providing access to the tube lanes, including a car being insertible into the tube lanes through the servicing openings and being movable therein by remote control, a spraying head being supported on the car and having nozzles with orifices for spraying jets of blowdown water in a given direction into spaces between the tubes, suction lines having suction stubs for pumping off accumulated blowdown water, and extendible and retractible clamping feet disposed on the car for clamping the car to the tubes on at least one side of a tube lane along a clamping plane in conformity with the given tube pitch, the nozzles being positioned in spraying positions of a spraying position sequence by the clamping feet clamping the car, the given spraying direction from the orifices of the nozzles being adjusted to the given tube pitch and the nozzles being spaced from the clamping plane by a distance being adjusted to the given tube pitch for spraying the jets of water into the spaces between the tubes and a method for carrying out a spraying operation.

Abstract translation: 用于用于高压排放热交换器的管道车道操纵器，其具有由给定的间距形成管道间隔开的管道，其间具有在相对侧上的管，并且具有形成在其中的可关闭的维修开口，其提供对管道的通路，包括轿厢可插入 管道穿过维修开口并通过远程控制在其中可移动，喷雾头被支撑在汽车上并具有喷嘴，喷嘴具有用于沿给定方向喷射排放水的喷嘴的喷嘴以在管之间的空间中，吸入管线具有用于 抽出积聚的排污水，以及设置在轿厢上的可伸缩夹紧脚，沿着夹紧平面在管道的至少一侧将管道夹紧在管道上，使其与给定的管子间距一致， 通过夹紧脚夹住车辆的喷射位置顺序的位置，给定的喷射方向 喷嘴的孔被调节到给定的管间距，并且喷嘴与夹紧平面隔开一定距离，被调整到给定的管间距，用于将水喷射喷射到管之间的空间中，并且执行一种方法 喷涂操作。

公开(公告)号：US4487165A

公开(公告)日：1984-12-11

申请号：US572174

申请日：1984-01-18

Applicant: Jakob Weber ,  Josef Forster ,  Robert Weber

Inventor： Jakob Weber ,  Josef Forster ,  Robert Weber

IPC: F22B37/54 ,  F28G15/00 ,  F22B37/52

CPC classification number: F22B37/54 ,  F28G15/00

Abstract: A tube lane manipulator assembly for the high-pressure blowdown of heat exchangers of steam generators includes a manipulator, at least one vehicle disposed on the manipulator having a lower base body with a substantially rectangular cross section, a spraying head with nozzles on the vehicle, the vehicle being insertible into tube lanes of the tubes of the generator through service openings and being movable in the tube lanes by remote control, the spraying head being movable into position for spraying jets into interspaces between the tubes, at least two clamping legs disposed in tandem in the feed direction on a side of the vehicle for clamping the vehicle to the tubes in conformity with a tube pitch in a clamping plane on at least one side of the tube lane for positioning the nozzles in spraying positions, the spraying direction of the nozzles and the distance thereof from the clamping plane being matched to the tube pitch for directing the spray jets into the interspaces, and at least one L-shaped guide rail extended along a feed direction within a tube lane forming an abutment for the clamping legs and a guide for the vehicle, the guide rail having a vertical leg facing away from the first row of tubes and a horizontal leg defining a space between the legs being limited in width by the row of tubes closest to the tube lane for receiving the lower base body.

Abstract translation: 用于蒸汽发生器的热交换器的高压排放的管道车道操纵器组件包括操纵器，设置在操纵器上的至少一个车辆，具有基本上矩形截面的下基体，在车辆上具有喷嘴的喷头， 车辆可通过操作开口插入到发电机的管道的管道中，并且可以通过远程控制在管道中移动，喷头可移动到位置，以将射流喷射到管之间的间隙中，至少两个夹紧腿设置在 在车辆一侧的进给方向上串联，以便在车道的至少一侧的夹紧平面中与管子夹紧车辆至管，用于将喷嘴定位在喷射位置，喷雾方向 喷嘴及其与夹紧平面的距离与管节距相匹配，用于将喷射射流引导到间隙中，并且在le 一个L形导轨在管道内沿进给方向延伸，形成用于夹持腿的邻接件和用于车辆的引导件，该导轨具有背离第一排管的垂直腿和限定 腿之间的空间被最靠近管道的管排限制在宽度上，用于接纳下基体。

公开(公告)号：US4291579A

公开(公告)日：1981-09-29

申请号：US58423

申请日：1979-07-18

Applicant: Dietgar Figlhuber ,  Johannes Gallwas ,  Robert Weber ,  Jakob Weber

Inventor： Dietgar Figlhuber ,  Johannes Gallwas ,  Robert Weber ,  Jakob Weber

IPC: G01N29/04 ,  G01N29/26 ,  G01N29/265 ,  G21C17/003 ,  G21C17/007

CPC classification number: G21C17/007 ,  G01N29/265 ,  G01N2291/2695

Abstract: Inspection device for testing vessels surrounded by a wall having an inner and an outer surface including a movable testing device and a track for guiding the testing device. The guiding track extending from a portion disposed in the vicinity of the vessel between the wall and the vessel, through a U-shaped portion over the wall and ending at a rest position for the testing device on the outer surface of the wall.

Abstract translation: 用于测试由具有内表面和外表面的壁包围的容器的检查装置，包括可移动测试装置和用于引导测试装置的轨道。 引导轨道从位于壁和容器之间的容器附近的部分延伸通过壁上的U形部分并且终止于在壁的外表面上的测试装置的静止位置。