-
公开(公告)号：US20240358809A1
公开(公告)日：2024-10-31
申请号：US18765553
申请日：2024-07-08
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
CPC分类号： A61K39/00115 , A61K39/39 , A61P35/00 , C07K16/40 , C12N15/52 , C12N15/62 , A61K2039/53 , A61K2039/55527 , A61K2039/575
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens are disclosed. Methods of treating a subject with a Survivin-expressing tumor and methods of preventing a Survivin-expressing tumor are disclosed. Synthetic consensus Survivin antigens are disclosed.
-
公开(公告)号：US12049479B2
公开(公告)日：2024-07-30
申请号：US17474732
申请日：2021-09-14
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/135 , A61K38/20 , A61K39/12 , A61K39/39 , A61M37/00 , A61N1/32 , C07K14/005 , C07K14/09 , C12N7/00 , G01N33/569 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61M37/00 , A61N1/327 , C12N7/00 , G01N33/56983 , A61K2039/523 , A61K2039/53 , A61K2039/552 , C12N2770/32122 , C12N2770/32134 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
-
3.发明公开公开(公告)号：US20240226291A9
公开(公告)日：2024-07-11
申请号：US18477785
申请日：2023-09-29
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
CPC分类号： A61K39/42 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , A61K2039/53
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
-
公开(公告)号：US20240132971A1
公开(公告)日：2024-04-25
申请号：US18493936
申请日：2023-10-24
IPC分类号： C12Q1/6886 , A61K39/12
CPC分类号： C12Q1/6886 , A61K39/12 , A61K2039/53 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
摘要： Described are methods of treating human papillomavirus (HPV) type 16- or HPV type 18-related High-grade Squamous Intraepithelial Lesion (HSIL) of the cervix. The described methods comprise evaluating one or more biological samples for the presence of miRNAs and isomiRs thereof.
-
公开(公告)号：US20240123052A1
公开(公告)日：2024-04-18
申请号：US18486708
申请日：2023-10-13
发明人： Stephanie Ramos , Jewell Walters , Jian Yan , Anna Slager , Charles Reed , Kate Broderick
CPC分类号： A61K39/12 , A61K9/0019 , A61P31/20 , A61K2039/54
摘要： Provided herein are nucleic acid molecules encoding an HPV antigen. Also provided are vaccines against human papillomavirus (HPV) comprising the nucleic acids, methods of inducing immune responses, and methods for prophylactically and/or therapeutically immunizing individuals against recurrent respiratory papillomatosis (RRP). Pharmaceutical compositions, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well as methods of inducing an immune response to treat or prevent RRP are disclosed.
-
公开(公告)号：US11896654B2
公开(公告)日：2024-02-13
申请号：US16098925
申请日：2017-05-05
申请人： The Trustees of the University of Pennsylvania , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , Inovio Pharmaceuticals, Inc.
IPC分类号： A61K39/00 , C12N15/85 , C07K16/28 , A61K31/7088 , A61P35/00 , A61K39/395
CPC分类号： A61K39/001129 , A61K31/7088 , A61K39/395 , A61P35/00 , C07K16/2803 , C07K16/2818 , C07K16/2878 , C12N15/85 , A61K2039/505 , A61K2039/53
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets an immune checkpoint molecule. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
-
公开(公告)号：US11845787B2
公开(公告)日：2023-12-19
申请号：US16497945
申请日：2018-03-27
发明人： David Weiner , Megan Wise
CPC分类号： C07K16/1045 , A61P31/18 , C07K2317/55 , C07K2317/76
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an HIV antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an HIV infection in a subject using said composition and method of generation.
-
公开(公告)号：US20230293653A1
公开(公告)日：2023-09-21
申请号：US18162104
申请日：2023-01-31
发明人： David B. Weiner , Jian Yan , Jewell Walters
CPC分类号： A61K39/001153 , C07K14/4748 , A61K2039/53
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.
-
9.发明申请公开(公告)号：US20230017972A1
公开(公告)日：2023-01-19
申请号：US17855349
申请日：2022-06-30
摘要： An injection device for in vivo delivery of an agent includes a tubular body defining a lumen that extends along a central axis that is oriented along a longitudinal direction. A distal end of the lumen is occluded and the tubular body defines at least one side-port extending from the lumen to an outer surface of the tubular body. The at least one side-port is elongated along the outer surface of the tubular body.
-
公开(公告)号：US20230012022A1
公开(公告)日：2023-01-12
申请号：US17813762
申请日：2022-07-20
发明人： David B. Weiner , Jian Yan , Karuppiah Muthumani , Jewell Walters
IPC分类号： A61K39/00 , A61K39/395 , C12N9/02
摘要： Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
-
-
-
-
-
-
-
-
-
搜索结果
195 条记录 (耗时 0.034 秒)
