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公开(公告)号：US20190175708A1
公开(公告)日：2019-06-13
申请号：US16219460
申请日：2018-12-13
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen are disclosed. Methods of treating a subject with a MUC16-expressing tumor and methods of preventing a MUC16-expressing tumor are disclosed. Modified consensus MUC16 antigen is disclosed.
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公开(公告)号：US20240358809A1
公开(公告)日：2024-10-31
申请号：US18765553
申请日：2024-07-08
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
CPC分类号： A61K39/00115 , A61K39/39 , A61P35/00 , C07K16/40 , C12N15/52 , C12N15/62 , A61K2039/53 , A61K2039/55527 , A61K2039/575
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens are disclosed. Methods of treating a subject with a Survivin-expressing tumor and methods of preventing a Survivin-expressing tumor are disclosed. Synthetic consensus Survivin antigens are disclosed.
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公开(公告)号：US20210401959A1
公开(公告)日：2021-12-30
申请号：US17467728
申请日：2021-09-07
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus mesothelin antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus mesothelin antigen are disclosed. Methods of treating a subject with a mesothelin-expressing tumor and methods of preventing a mesothelin-expressing tumor are disclosed. Modified consensus mesothelin antigen is disclosed.
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公开(公告)号：US20220111026A1
公开(公告)日：2022-04-14
申请号：US17559824
申请日：2021-12-22
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus MUC16 antigen are disclosed. Methods of treating a subject with a MUC16-expressing tumor and methods of preventing a MUC16-expressing tumor are disclosed. Modified consensus MUC16 antigen is disclosed.
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公开(公告)号：US20190175712A1
公开(公告)日：2019-06-13
申请号：US16219446
申请日：2018-12-13
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus LEMD1 antigen are disclosed. Methods of treating a subject with a LEMD1-expressing tumor and methods of preventing a LEMD1-expressing tumor are disclosed. Mutated consensus LEMD1 antigen is disclosed.
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公开(公告)号：US20190175707A1
公开(公告)日：2019-06-13
申请号：US16219520
申请日：2018-12-13
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens are disclosed. Methods of treating a subject with a Survivin-expressing tumor and methods of preventing a Survivin-expressing tumor are disclosed. Synthetic consensus Survivin antigens are disclosed.
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公开(公告)号：US20210401958A1
公开(公告)日：2021-12-30
申请号：US17479142
申请日：2021-09-20
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
IPC分类号： A61K39/00
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a synthetic consensus BORIS antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a synthetic consensus BORIS antigen are disclosed. Methods of treating a subject with a BORIS-expressing tumor and methods of preventing a BORIS-expressing tumor are disclosed. A synthetic consensus BORIS antigen is disclosed.
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公开(公告)号：US20190175713A1
公开(公告)日：2019-06-13
申请号：US16219356
申请日：2018-12-13
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a mutated consensus PRAME antigen are disclosed. Methods of treating a subject with a PRAME-expressing tumor and methods of preventing a PRAME-expressing tumor are disclosed. Mutated consensus PRAME antigen is disclosed.
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公开(公告)号：US20190175711A1
公开(公告)日：2019-06-13
申请号：US16219287
申请日：2018-12-13
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a modified consensus mesothelin antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a modified consensus mesothelin antigen are disclosed. Methods of treating a subject with a mesothelin-expressing tumor and methods of preventing a mesothelin-expressing tumor are disclosed. Modified consensus mesothelin antigen is disclosed.
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公开(公告)号：US20190175710A1
公开(公告)日：2019-06-13
申请号：US16219268
申请日：2018-12-13
发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH
IPC分类号： A61K39/00
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a synthetic consensus BORIS antigen. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode a synthetic consensus BORIS antigen are disclosed. Methods of treating a subject with a BORIS-expressing tumor and methods of preventing a BORIS-expressing tumor are disclosed. A synthetic consensus BORIS antigen is disclosed.
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