公开(公告)号：US11705248B2

公开(公告)日：2023-07-18

申请号：US16567585

申请日：2019-09-11

申请人： FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ,  HEMOPHOTONICS, S.L.

发明人： Turgut Durduran ,  Jonas Fischer ,  Ameer Ghouse ,  Udo Weigel

IPC分类号： G16H70/60

CPC分类号： G16H70/60

摘要： System and computer-implemented method for detecting and categorizing pathologies through an analysis of pulsatile blood flow. The method has a pulsatile blood flow signal of a subject, extracting a set of features from the pulsatile blood flow signal; and categorizing a pathology based on the extracted features. The extracted features may be predetermined features or features learned through a machine learning algorithm. For the categorization, a classification or a regression algorithm may be used to provide an index or a value score as a biomarker. Additional static features of the subject may be used in the categorization.

公开(公告)号：US20200090819A1

公开(公告)日：2020-03-19

申请号：US16567585

申请日：2019-09-11

申请人： FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ,  HEMOPHOTONICS, S.L.

发明人： Turgut DURDURAN ,  Jonas FISCHER ,  Ameer GHOUSE ,  Udo WEIGEL

IPC分类号： G16H70/60

摘要： System and computer-implemented method for detecting and categorizing pathologies through an analysis of pulsatile blood flow. The method has a pulsatile blood flow signal of a subject, extracting a set of features from the pulsatile blood flow signal; and categorizing a pathology based on the extracted features. The extracted features may be predetermined features or features learned through a machine learning algorithm. For the categorization, a classification or a regression algorithm may be used to provide an index or a value score as a biomarker. Additional static features of the subject may be used in the categorization.

公开(公告)号：US20170102604A1

公开(公告)日：2017-04-13

申请号：US15129479

申请日：2015-03-27

申请人： Fundacio Institut De Ciencies Fotoniques (ICFO) ,  Institucio Catalana De Recerca I Estudis Avancats (ICREA)

发明人： Majid Ebrahim-Zadeh ,  Suddappali Chaitanya Kumar

IPC分类号： G02F1/39

CPC分类号： G02F1/39 ,  G02F2201/16 ,  H01S3/0092 ,  H01S3/06708 ,  H01S3/1106 ,  H01S3/1618

摘要： An optical parametric oscillator (3) is configured to provide first ultrashort output pulses comprising light of a first wavelength and second ultrashort output pulses comprising light of a second wavelength, wherein at least one of the first and second wavelengths is independently controllable. The optical parametric oscillator (3) comprises an optical resonator (10) containing first and second nonlinear optical elements (11, 12) and comprising an output coupler (13), an input system (14) configured to provide first pump pulses to the first nonlinear optical element (11) and second pump pulses to the second nonlinear optical element (12), and a control system (15).

公开(公告)号：US20190309299A1

公开(公告)日：2019-10-10

申请号：US15944499

申请日：2018-04-03

申请人： Fundacio Institut de Recerca Biomedica (IRB Barcelona) ,  Institucio Catalana de Recerca I Estudis Avancats

发明人： Roger GOMIS ,  Anna Arnal ,  Maria Tarragona ,  Milica Pavlovic ,  Evarist Planet

IPC分类号： C12N15/113 ,  A61K38/17 ,  C07K16/32 ,  C12Q1/6886

摘要： This study describes a method to determine the likelihood of the development of metastasis in a subject suffering from cancer, in addition to a method to design a customized therapy in a subject suffering from cancer, in particular breast, colon, lung, kidney and thyroid cancer, based on the determination of the expression level of one or more genes whose expression is modulated by an increase in c-MAF expression. It also describes a method for the identification of marker genes with a propensity for metastatic cancer based on inducing the modulation of the c-MAF expression Finally, the use of PTHLH and PODXL inhibitors and RERG activators in the treatment and/or prevention of the cancer, in particular breast, colon, lung, kidney and thyroid cancer.

公开(公告)号：US20190169693A1

公开(公告)日：2019-06-06

申请号：US16028530

申请日：2018-07-06

申请人： FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA ) ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS

发明人： Roger GOMIS ,  Maria Tarragona ,  Anna Arnal ,  Milica Pavlovic

IPC分类号： C12Q1/6886 ,  C12N15/113 ,  C07K16/24 ,  G01N33/574 ,  C07F9/6506

摘要： The present invention relates to a method for the diagnosis or the prognosis of metastasis in breast cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in ER− breast cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the ER− breast cancer metastasis.

公开(公告)号：US20170370948A1

公开(公告)日：2017-12-28

申请号：US15543151

申请日：2015-07-28

申请人： FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA (ICIQ) ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ,  UNIVERSITAT ROVIRA I VIRGILI

发明人： Louis ADRIAENSSENS ,  Pau BALLESTER ,  Francisco Javier ANDRADE ,  Pascal BLONDEAU ,  Francesc Xavier RIUS ,  Tomas De Aquino GUINOVART PAVON ,  Daniel HERNANDEZ ALONSO

IPC分类号： G01N33/70 ,  C08K5/55 ,  C08K5/5373 ,  C07D491/22 ,  B01J39/16 ,  C08J5/22 ,  C07F9/6571 ,  G01N27/40 ,  C08K5/32

CPC分类号： G01N33/70 ,  B01J39/16 ,  C07D403/14 ,  C07D487/22 ,  C07D491/22 ,  C07F9/657181 ,  C08J5/22 ,  C08J2327/06 ,  C08K5/32 ,  C08K5/5373 ,  C08K5/55 ,  G01N27/40

摘要： Compounds are of the formula (Ia), (Ib), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3 C20)alkynyl; (C1-C6)alkyl-O—; (C3-C20)cycloalkyl; (C1 C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted; R2 and R2′ are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O—; (C1-C6)haloalkyl; halogen;cyano; and nitro; Z1 to Z4 are diradicals of formula (III) wherein Al and A2 are O—or —NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1-C20)alkyl; and G is (C1-C6)alkyl; —P(═S)R5-; —P(═O)R4; P(═O)(OR4)-; —P(═O)(NR6R7)-; —S(=0)2-; S(═O)—; or —C(═O)—; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8.

公开(公告)号：US20170202950A1

公开(公告)日：2017-07-20

申请号：US15463176

申请日：2017-03-20

申请人： LABORATORIOS DEL DR ESTEVE, S.A. ,  FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CA ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ,  UNIVERSITY OF WASHINGTON

发明人： Beatriz MOTHE PUJADAS ,  Christian BRANDER ,  James I. MULLINS

IPC分类号： A61K39/21 ,  C12N7/00 ,  C07K14/005

CPC分类号： A61K39/21 ,  A61K38/00 ,  A61K39/12 ,  A61K2039/572 ,  C07K7/08 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16222 ,  C12N2740/16234 ,  G01N33/505 ,  G01N2333/161

摘要： The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.

公开(公告)号：US20170101683A1

公开(公告)日：2017-04-13

申请号：US15027946

申请日：2014-10-07

申请人： FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS

发明人： Roger GOMIS ,  Evarist PLANET ,  Milica Pavlovic ,  Anna ARNAL ,  Maria TARRAGONA

IPC分类号： C12Q1/68 ,  C07K16/28

摘要： The present invention relates to a method for the prognosis of bone metastasis in HER2+ breast cancer, which comprises determining if the MAF gene is amplified in a primary tumor sample. Likewise, the present invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the MAF gene expression level, amplification or translocation. The present invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The present invention also relates to a c-Maf inhibitor as therapeutic agent for use in the treatment of HER2+ breast cancer metastasis. The present invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the present invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort.

公开(公告)号：US20160326227A1

公开(公告)日：2016-11-10

申请号：US15023131

申请日：2014-10-16

申请人： INSTITUT D'INVESTIGACIONES BIOMEDIQUES AUGUST PI I SUNYER ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS

发明人： Josep Dalmau

IPC分类号： C07K14/47 ,  G01N33/94 ,  G01N33/564

CPC分类号： C07K14/4713 ,  A61K38/00 ,  G01N33/564 ,  G01N33/9426 ,  G01N2333/70571 ,  G01N2800/2857

摘要： The present invention provides a use of a GABA(A)R, GABA(A)R fragment, or homolog thereof or a cell expressing the GABA(A)R, GABA(A)R fragment, or homolog thereof for the prognosis, diagnosis or treatment of an autoimmune disease in a subject, methods of prognosticating, diagnosing or treating an autoimmune disease, an autoantibody binding to a GABA(A)R, GABA(A)R fragment, or homolog thereof, a method for isolating an antibody binding to a GABA(A)R, GABA(A)R fragment, or homolog thereof, and a test kit, pharmaceutical composition and medical or diagnostic device comprising a GABA(A)R, GABA(A)R fragment, or homolog thereof.

摘要翻译： 本发明提供了GABA（A）R，GABA（A）R片段或其同源物或表达GABA（A）R，GABA（A）R片段或其同源物的细胞用于预后，诊断的用途 或治疗受试者中的自身免疫疾病，预后，诊断或治疗自身免疫疾病的方法，与GABA（A）R，GABA（A）R片段或其同系物结合的自身抗体，分离抗体结合的方法 （A）R，GABA（A）R片段或其同源物，以及包含GABA（A）R，GABA（A）R片段或其同系物的测试试剂盒，药物组合物和医学或诊断装置。

公开(公告)号：US20150197426A1

公开(公告)日：2015-07-16

申请号：US14415479

申请日：2013-06-28

申请人： UNIVERSITA DEGLI STUDI DI SASSARI ,  UNIVERSITA AUTONOMA DE BARCELONA (UAB) ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA)

发明人： Gabriele Mulas ,  Sebastiano Garroni ,  Elisa Tolu ,  Eva Maria Pellicer Vila ,  Maria Dolors Baro Marine ,  Jordi Sort Vinas

IPC分类号： C01G33/00

CPC分类号： C01G33/00 ,  C01P2002/02 ,  C01P2002/04 ,  C01P2002/50 ,  C01P2002/72 ,  C01P2002/88 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  C01P2006/17 ,  C04B35/495 ,  C04B35/6264 ,  C04B35/62655 ,  C04B35/6266 ,  C04B35/62675 ,  C04B35/63488 ,  C04B2235/3206 ,  C04B2235/3251 ,  C04B2235/44 ,  C04B2235/444 ,  C04B2235/5409 ,  C04B2235/81

摘要： The present invention concerns a Magnesium (Mg) and Niobium (Nb) ternary oxide with very high morphological order degree having Mg11.1Nb22.2O66.7 atomic percentage composition which, due to the chemical composition and morphological and nanostructural properties, can be used in various fields of technological interest, specifically it is suitable to be used as dielectric material for capacitors, as material for hydrogen confinement and energy storage.

摘要翻译： 本发明涉及具有Mg11.1Nb22.2O66.7原子百分比组成的具有非常高的形态顺序度的镁（Mg）和铌（Nb）三元氧化物，由于其化学组成和形态和纳米结构性质，可以用于 各种技术领域，特别适合用作电容器的介电材料，作为氢限制和能量储存的材料。