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公开(公告)号：US07989634B2
公开(公告)日：2011-08-02
申请号：US10579042
申请日：2004-11-12
Applicant: Koo Lee , Heui-Sul Park , In-Ae Ahn , Hyun-Ju Yoo , Jong-Yup Kim , Deog-Young Choi , Hyeon-Joo Yim , Kyung-Ha Chung , Dong-Sup Shim , Sang-Kyun Lee , Yutaka Kondoh , Ryoji Hirabayashi , Shugo Honda , Hidetaka Kaku , Jun-ichi Shishikura , Hiroyuki Ito , Takeshi Kurama
Inventor： Koo Lee , Heui-Sul Park , In-Ae Ahn , Hyun-Ju Yoo , Jong-Yup Kim , Deog-Young Choi , Hyeon-Joo Yim , Kyung-Ha Chung , Dong-Sup Shim , Sang-Kyun Lee , Yutaka Kondoh , Ryoji Hirabayashi , Shugo Honda , Hidetaka Kaku , Jun-ichi Shishikura , Hiroyuki Ito , Takeshi Kurama
IPC: C07D213/46 , C07D211/70 , C07D401/00
CPC classification number: C04B35/632 , C07D205/04 , C07D207/14 , C07D211/58 , C07D401/12 , C07D403/12 , C07D405/12
Abstract: The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.
Abstract translation: 本发明涉及有效作为黑皮质素受体激动剂的式1化合物及其药学上可接受的盐，水合物，溶剂化物或异构体，以及包含与活性成分相同的黑皮质素受体激动剂组合物。
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公开(公告)号：US09074980B2
公开(公告)日：2015-07-07
申请号：US13278716
申请日：2011-10-21
Applicant: Tae-Hyun Yoon , Song-Hee Lee , Dong-Wook Kwon , Jong-Hoon Park , Hyun-Ju Yoo , Hyun-Woo Nho
Inventor： Tae-Hyun Yoon , Song-Hee Lee , Dong-Wook Kwon , Jong-Hoon Park , Hyun-Ju Yoo , Hyun-Woo Nho
IPC: C12Q1/18 , G01N21/64 , G01N21/29 , G01N15/14 , G01N15/04 , G01N33/50 , B82Y5/00 , B82Y35/00 , G01N15/00 , G01N15/10
CPC classification number: G01N15/1475 , G01N15/04 , G01N15/147 , G01N15/1484 , G01N21/6458 , G01N21/648 , G01N33/5014 , G01N2015/0038 , G01N2015/0092 , G01N2015/1075 , G01N2015/1486 , G01N2015/1497 , G01N2510/00
Abstract: The present invention relates to a method for the toxicity assessment of nano-materials, and more specifically, it is relates to an objective, reproducible and accurate assessment method for the unbiased toxicity testings of nano-materials, which minimize artifacts of the conventional methods for the toxicity assessment of the nano-materials by considering the dose characteristics of the nano-material itself using Selective multi-Plane Illumination Microcopy (SPIM); and the response characteristics of the nano-material using the improved or novel cellular responses assessment methods for nano-materials (e.g., modified MTT assay using image cytometric analysis, normal-inverted exposure apparatus, and modified flow cytometry), and a system and an apparatus thereof.
Abstract translation: 本发明涉及一种纳米材料的毒性评估方法，更具体地说，本发明涉及一种用于纳米材料的无偏差毒性试验的客观，可重现和准确的评估方法，其使常规方法的伪影最小化 通过使用选择性多平面照明显微镜（SPIM）考虑纳米材料本身的剂量特征，对纳米材料的毒性评估; 以及纳米材料的改进或新型细胞应答评估方法（例如，使用图像细胞计数分析，正常反转曝光装置和修饰的流式细胞术的修饰MTT测定）的纳米材料的响应特性，以及系统和 装置。
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公开(公告)号：US20120219985A1
公开(公告)日：2012-08-30
申请号：US13278716
申请日：2011-10-21
Applicant: Tae-Hyun Yoon , Song-Hee Lee , Dong-Wook Kwon , Jong-Hoon Park , Hyun-Ju Yoo , Hyun-Woo Nho
Inventor： Tae-Hyun Yoon , Song-Hee Lee , Dong-Wook Kwon , Jong-Hoon Park , Hyun-Ju Yoo , Hyun-Woo Nho
CPC classification number: G01N15/1475 , G01N15/04 , G01N15/147 , G01N15/1484 , G01N21/6458 , G01N21/648 , G01N33/5014 , G01N2015/0038 , G01N2015/0092 , G01N2015/1075 , G01N2015/1486 , G01N2015/1497 , G01N2510/00
Abstract: The present invention relates to a method for the toxicity assessment of nano-materials, and more specifically, it is relates to an objective, reproducible and accurate assessment method for the unbiased toxicity testings of nano-materials, which minimize artifacts of the conventional methods for the toxicity assessment of the nano-materials by considering the dose characteristics of the nano-material itself using Selective multi-Plane Illumination Microcopy (SPIM); and the response characteristics of the nano-material using the improved or novel cellular responses assessment methods for nano-materials (e.g., modified MTT assay using image cytometric analysis, normal-inverted exposure apparatus, and modified flow cytometry), and a system and an apparatus thereof.
Abstract translation: 本发明涉及一种纳米材料的毒性评估方法，更具体地说，本发明涉及一种用于纳米材料的无偏差毒性试验的客观，可重现和准确的评估方法，其使常规方法的伪影最小化 通过使用选择性多平面照明显微镜（SPIM）考虑纳米材料本身的剂量特征，对纳米材料的毒性评估; 以及纳米材料的改进或新型细胞应答评估方法（例如，使用图像细胞计数分析，正常反转曝光装置和修饰的流式细胞术的修饰MTT测定）的纳米材料的响应特性，以及系统和 装置。
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公开(公告)号：US20070129346A1
公开(公告)日：2007-06-07
申请号：US10579042
申请日：2004-11-12
Applicant: Koo Lee , Heui-Sul Park , In-Ae Ahn , Hyun-Ju Yoo , Jong-Yup Kim , Deog-Young Choi , Hyeon-Joo Yim , Kyung-Ha Chung , Dong-Sup Shim , Sang-Kyun Lee , Yutaka Kondoh , Ryoji Hirabayashi , Shugo Honda , Hidetaka Kaku , Jun-ichi Shishikura , Hiroyuki Ito , Takeshi Kurama
Inventor： Koo Lee , Heui-Sul Park , In-Ae Ahn , Hyun-Ju Yoo , Jong-Yup Kim , Deog-Young Choi , Hyeon-Joo Yim , Kyung-Ha Chung , Dong-Sup Shim , Sang-Kyun Lee , Yutaka Kondoh , Ryoji Hirabayashi , Shugo Honda , Hidetaka Kaku , Jun-ichi Shishikura , Hiroyuki Ito , Takeshi Kurama
IPC: A61K31/397 , A61K31/401 , A61K31/445 , C07D211/06
CPC classification number: C04B35/632 , C07D205/04 , C07D207/14 , C07D211/58 , C07D401/12 , C07D403/12 , C07D405/12
Abstract: The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.
Abstract translation: 本发明涉及有效作为黑皮质素受体激动剂的式1化合物及其药学上可接受的盐，水合物，溶剂化物或异构体，以及包含与活性成分相同的黑皮质素受体激动剂组合物。
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