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    INHIBITION OF FKBP1A FOR THE TREATMENT OF TRIPLE-NEGATIVE MAMMARY CARCINOMA
    1.
    发明申请
    INHIBITION OF FKBP1A FOR THE TREATMENT OF TRIPLE-NEGATIVE MAMMARY CARCINOMA 有权

    公开(公告)号：US20230133761A1

    公开(公告)日：2023-05-04

    申请号：US17801547

    申请日：2021-03-11

    申请人： Heinrich-Heine-Universität Düsseldorf

    发明人： Knud Esser ,  Andrea Kulik ,  Tanja Fehm ,  Judith Steimel

    IPC分类号： G01N33/50 ,  G01N33/574

    摘要： The invention relates to a method for finding inhibitors of the peptidyl-prolyl cis-trans isomerase FKBP1A or antibodies, proteins or molecules having a specific affinity to FKBP1A. The invention also relates to FKBP1A-specific siRNA, inhibitors of the expression of FKBP1A, inhibitors of the enzymatic activity of FKBP1A, and inhibitors of the interaction(s) of FKBP1A with interaction partner(s), in each case for the treatment of diseases, in particular cancers or neurodegenerative diseases. The invention further relates to the use of FKBP1A as a prognostic or diagnostic marker for cancers. The cancers are preferably mammary carcinoma, in particular triple-negative mammary carcinoma, in this case very particularly the mesenchymal stem-like sub-type.

    Selective inhibition of C4-PEP carboxylases
    3.
    发明授权
    Selective inhibition of C4-PEP carboxylases 有权

    公开(公告)号：US10188107B2

    公开(公告)日：2019-01-29

    申请号：US14761088

    申请日：2014-01-16

    申请人： Heinrich Heine Universität Düsseldorf

    发明人： Georg Groth ,  Judith Katharina Paulus ,  Daniel Schlieper ,  Peter Westhoff

    IPC分类号： A01N43/90 ,  A01N31/16 ,  A01N35/04 ,  A01N37/40 ,  A01N43/26 ,  A01N43/30 ,  A01N43/32 ,  A01N43/16 ,  A01N43/60

    摘要： The present invention relates to the use of a compound, a salt or solvate thereof as C4 plant selective herbicide wherein said compound has a structure according to formula (I) wherein A is a cyclic alkyl, aryl, heterocycloalkyl, or heteroaryl group, and B is a cyclic alkyl, aryl, heterocycloalkyl, or heteroaryl group, and wherein R1, R2, R3, R4 and R5 are, independently of each other H or an alkyl group, and wherein integer i is 0 or 1, preferably 1, and the bond (a) is a single or double bond, and wherein in case (a) is a double bond, n is 0 and X is O or S, and wherein in case (a) is a single bond n is 1, and X is H or an alkyl group, and wherein the bond (b) is a single or double bond, and wherein in case (b) is a double bond, m and p are 0, and wherein in case (b) is a single bond m and p are both 1, and/or according to formula (II) including tautomeric structures thereof, wherein R01 and R02 are independently of each other selected from the group consisting of H, OH, carboxylic acid, ester, alkyl, alkoxy and halogen, wherein Y1 is selected from the group consisting of (S(═O)2), S(═O)) and (C(═O)), and wherein Y2 is O, and wherein r is 0 or 1 and wherein in case r is 0, q and s are 1, and wherein in case r is 1, q and s are 0, and wherein R01, R02, R04, R05, R06, R07, R04#, R05#, R06#, R07#, R09, R010, R011 and R012 are independently of each other selected from the group consisting of H, OH, —SO3H, carboxylic acid, ester, alkyl, alkoxy and halogen, said compound being capable of binding to the malate binding site comprised by a phosphoenolpyruvate carboxylase from a C4 plant, thereby inhibiting said phosphoenolpyruvate carboxylase.

    Sensor and method for manufacturing a sensor
    10.
    发明申请
    Sensor and method for manufacturing a sensor 有权
    用于制造传感器的传感器和方法

    公开(公告)号：US20140291160A1

    公开(公告)日：2014-10-02

    申请号：US14351097

    申请日：2012-10-10

    申请人： HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF

    发明人： Klaus Schierbaum ,  Mhamed El Achhab ,  Christiane Schüle

    IPC分类号： G01N27/26 ,  C25D7/00

    CPC分类号： G01N27/127 ,  C25D7/00 ,  G01N27/125 ,  G01N27/26

    摘要： The present invention refers to a sensor (10) having a layer arrangement (12), wherein the layer arrangement (12) comprises at least a base layer (14), a middle layer (16) and an outer layer (18), wherein the middle layer (16) is arranged at least partly upon and in contact with the base layer (14) and wherein the outer layer (18) is arranged at least partly upon and in contact with the middle layer (16), wherein the base layer (14) comprises a metal, wherein the middle layer (16) comprises a metal oxide, and wherein the outer layer (18) is porous and comprises a material selected from the group comprising electrically conductive carbon compounds such as, more particularly, graphite or carbon nanotubes (CNTs), organic electrical conductors and base metals, and wherein electrical contacts can be formed with the base layer (14) and outer layer (18) for a conductivity measurement and/or a resistance measurement. Such a sensor (10) provides a high sensitivity with a high selectivity already at ambient temperature and is furthermore producible especially cost-saving. The present invention further refers to a method for producing a sensor (10). The present invention further refers to the use of a sensor (10) according to the invention as gas sensor and/or as liquid sensor.

    摘要翻译： 本发明涉及具有层布置（12）的传感器（10），其中层布置（12）至少包括基层（14），中间层（16）和外层（18），其中 所述中间层（16）至少部分地布置在所述基底层（14）上并与所述基底层（14）接触，并且其中所述外层（18）至少部分地布置在所述中间层（16）上并与所述中间层（16）接触，其中所述基底 层（14）包括金属，其中中间层（16）包括金属氧化物，并且其中外层（18）是多孔的，并且包括选自包括导电碳化合物的材料，特别是石墨 或碳纳米管（CNT），有机电导体和贱金属，并且其中可以与基底层（14）和外层（18）形成电接触以进行电导率测量和/或电阻测量。 这种传感器（10）在环境温度下已经具有高选择性的高灵敏度，并且进一步可生产，特别是节省成本。 本发明还涉及一种用于制造传感器（10）的方法。 本发明还涉及使用根据本发明的传感器（10）作为气体传感器和/或液体传感器。