公开(公告)号：US20240068884A1

公开(公告)日：2024-02-29

申请号：US18267772

申请日：2022-01-12

申请人： SEMITEC Corporation ,  National Institute of Technology ,  HIROSAKI UNIVERSITY

发明人： Shigenao MARUYAMA ,  Yuya ISEKI ,  Takuma KOGAWA ,  Takashi NONAKA ,  Yasushi HOSOKAWA ,  Takahiro OKABE ,  Yutaro TABATA ,  Tadashi MATSUDATE ,  Toshinori NAKAJIMA ,  Masaya HIGASHI ,  Manabu ORITO

IPC分类号： G01K7/22 ,  G01K7/42 ,  G01K13/20

CPC分类号： G01K7/22 ,  G01K7/42 ,  G01K13/20

摘要： A thermosensitive part sensing temperature; a temperature sensor for measurement provided in the unit and measuring temperature by contacting the unit with a body to be measured; a temperature detecting part detecting, from when the unit contacts the body, the time when the sensor senses a difference from an initial temperature of the sensor, and a measured temperature of the sensor at that time, and detecting, from when the difference is sensed, a time after a certain length of time and a measured temperature of the sensor at that time; an estimating part estimating, from the time when the difference is sensed and a time after a certain length of time, the time when the thermosensitive part contacts the body, and the measured temperature at that time; and a heat conduction analyzing part estimating the measured temperature based on output information from the temperature detecting part and the estimating part.

公开(公告)号：US20230226133A1

公开(公告)日：2023-07-20

申请号：US18010833

申请日：2021-06-17

申请人： NIHON HARUMA KABUSHIKI KAISHA ,  HIROSAKI UNIVERSITY

发明人： Tsuyoshi Narumi ,  Junji Ichita ,  Kou Itoku ,  Naoki Nanashima ,  Akira Nakajima

IPC分类号： A61K36/73 ,  A61K31/164 ,  A61P25/28

CPC分类号： A61K36/73 ,  A61K31/164 ,  A61P25/28 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/53

摘要： A method for extracting a ceramide-containing material or ceramide from whole apples and/or apple juice extraction residue. Furthermore, to ensure utility as a food, especially a functional food, or a raw material for a cosmetic or medicine, that includes the ceramide-containing material. [Solution] In the present invention, an adsorbent is added to an ethanol treatment solution of whole apples and/or apple juice extraction residue, the mixture is stirred and subjected to solid-liquid separation, and solid material precipitated from the solution is separated, after which water is added to the resultant concentrate and the temperature thereof is maintained, whereby the resultant settled component is recovered and dried to obtain a ceramide-containing material or ceramide. Using the ceramide obtained from whole apples and/or apple juice extraction residue, there are formed a composition for promoting production of hyaluronic acid and/or type II collagen, and a composition for promoting improvement of memory impairment and/or enhancement of the level of phosphorylation of extracellular signal-related kinases (ERK1/2).

公开(公告)号：US20190383818A1

公开(公告)日：2019-12-19

申请号：US16464744

申请日：2017-11-29

申请人： KONICA MINOLTA, INC. ,  HIROSAKI UNIVERSITY

发明人： Tomonori KANEKO ,  Takatoshi KAYA ,  Chikara OHYAMA ,  Tohru YONEYAMA ,  Yuki TOBISAWA

IPC分类号： G01N33/574 ,  G01N21/64

摘要： The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a β-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.

公开(公告)号：US10509041B2

公开(公告)日：2019-12-17

申请号：US15956897

申请日：2018-04-19

申请人： HIROSAKI UNIVERSITY

发明人： Katsuya Yamada ,  Ayako Sasaki ,  Tadashi Teshima ,  Toshihiro Yamamoto ,  Yuji Otsuka

IPC分类号： G01N33/66 ,  C07H17/075 ,  C07H19/04 ,  A61K49/00 ,  A61K51/04 ,  C07H17/02 ,  G01N33/574 ,  G01N33/58

摘要： Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided is a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

公开(公告)号：US09885005B2

公开(公告)日：2018-02-06

申请号：US15126793

申请日：2015-03-09

申请人： KOHJIN LIFE SCIENCES CO., LTD. ,  HIROSAKI UNIVERSITY

发明人： Naoto Kaji ,  Shiroh Aida ,  Katsuhiro Osaki ,  Masato Omae ,  Tomohiro Nakagawa ,  Motoyuki Tokuriki ,  Hayato Maeda

IPC分类号： A61K47/00 ,  C11B1/02 ,  A23D9/013 ,  A61K31/66 ,  A23L33/12 ,  A61K31/661

CPC分类号： C11B1/025 ,  A23D9/013 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/66 ,  A61K31/661 ,  A61K31/685

摘要： [Problem] To provide a phospholipid α-linolenic acid composition of consistent quality and having a stable supply of source material, with focus on Torula yeast, which is edible and recognized as safe, in order to resolve issues with omega 3 sources.[Means for Solving the Problem] As a result of intensive study to resolve the above-noted issues, the inventors of the present invention have discovered that a phospholipid α-linolenic acid composition can be obtained using residue of yeast extract extracted from Torula yeast (Candida utilis), for example, which is currently produced in large quantities for application in foods, and so arrived at the present invention.

公开(公告)号：US20170315129A1

公开(公告)日：2017-11-02

申请号：US15513259

申请日：2015-09-24

申请人： Hirosaki University

发明人： Katsuya YAMADA ,  Ayako SASAKI ,  Kouki ONO ,  Kiyoshi TONE

IPC分类号： G01N33/58

摘要： The purpose of the present invention is to provide a novel cancer cell detection method that uses living body-derived cells and that can be used even in cytodiagnosis. In particular, the purpose of the present invention is to provide a novel cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. Provided is a cancer cell detection method that uses living body-derived cells and that includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate. Also provided is a dual detection method for cancer cells in which the cancer cell detection method that uses living body-derived cells is combined with a dyeing method using cells that are fixed using an alcohol or the like.

公开(公告)号：US09475826B2

公开(公告)日：2016-10-25

申请号：US14773172

申请日：2014-03-06

申请人： UNIMATEC CO., LTD. ,  HIROSAKI UNIVERSITY

发明人： Katsuyuki Sato ,  Hideo Sawada

IPC分类号： C07F7/08 ,  C07F7/02 ,  C07C31/38 ,  C08G77/18 ,  C08G77/24 ,  C07C29/149

CPC分类号： C07F7/025 ,  C07C29/149 ,  C07C31/38 ,  C08G77/18 ,  C08G77/24

摘要： Fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF-A-OH  [I] wherein RF is a perfluoroalkyl group or a polyfluoroalkyl group in which some of the fluorine atoms of the perfluoroalkyl group are replaced by hydrogen atoms, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane, or fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF′-A-OH  [Ia] or the general formula: HO-A-RF″-A-OH  [Ib] wherein RF′ is a linear or branched perfluoroalkyl group containing an O, S, or N atom, RF″ is a linear or branched perfluoroalkylene group containing an O, S, or N atom, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane.

公开(公告)号：US20160303191A1

公开(公告)日：2016-10-20

申请号：US15196413

申请日：2016-06-29

申请人： HIROSAKI UNIVERSITY ,  WAKITANI MEDICAL SCIENCE CORPORATION ,  SUNSTAR INC.

发明人： Yoji KATO ,  Shigeyuki WAKITANI ,  Yukako HANADA ,  Kazushi YAMAMOTO

IPC分类号： A61K38/17

CPC分类号： A61K38/1706 ,  A61K35/60

摘要： An object of the present invention is to provide a means for preventing or treating osteoarthritis. The present invention provides a composition for preventing or treating osteoarthritis, comprising a fish cartilage water extract containing proteoglycans having molecular weights of not less than 1,800,000.

公开(公告)号：US20160300998A1

公开(公告)日：2016-10-13

申请号：US15102244

申请日：2014-12-05

申请人： HIROSAKI UNIVERSITY ,  TOHOKU UNIVERSITY ,  TOHOKU STEEL Co., Ltd.

发明人： Yasufumi FURUYA ,  Shinichi YAMAURA ,  Takashi NAKAJIMA ,  Takashi EBATA ,  Takenobu SATO

IPC分类号： H01L41/47 ,  H01L41/20 ,  H01L41/12 ,  C22F1/10 ,  C22C19/07

CPC分类号： H01L41/47 ,  C22C19/07 ,  C22F1/10 ,  H01L41/125 ,  H01L41/20 ,  H02N2/00

摘要： A method for producing a magnetostrictive material and a method for increasing the value of magnetostriction can increase the value of magnetostriction of magnetostrictive materials used, for example, in vibration power generation and force sensors utilizing inverse magnetostriction phenomenon. A magnetostrictive material having a value of magnetostriction of 100 ppm or more is produced by melting and casting an alloy material in the composition of range of 67-87 wt % Co with the balance consisting of Fe and unavoidable impurities and then performing hot forging. Furthermore, a magnetostrictive material having a value of magnetostriction of 130 ppm or more can be produced by performing cold rolling after the hot forging. Heat treatment at 400-1000° C. may also be performed after hot working or cold working.

摘要翻译： 用于制造磁致伸缩材料的方法和增加磁致伸缩值的方法可以增加使用的磁致伸缩材料的磁致伸缩值，例如在振动发电和使用反磁致伸缩现象的力传感器中。 具有100ppm以上的磁致伸缩性的磁致伸缩材料通过熔融和铸造组合物中的合金材料在67-87重量％Co的范围内，余量由Fe和不可避免的杂质组成，然后进行热锻造而产生。 此外，通过在热锻后进行冷轧，可以制造磁致伸缩值为130ppm以上的磁致伸缩材料。 也可以在热加工或冷加工后进行400-1000℃的热处理。

公开(公告)号：US20160017198A1

公开(公告)日：2016-01-21

申请号：US14773173

申请日：2014-03-06

申请人： UNIMATEC CO., LTD. ,  HIROSAKI UNIVERSITY

发明人： Katsuyuki Sato ,  Hideo Sawada

IPC分类号： C09K3/18 ,  C08K3/36

CPC分类号： C09K3/18 ,  B82Y30/00 ,  C07C29/149 ,  C07C31/38 ,  C08K3/36

摘要： Fluorine-containing nano-silica composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF-A-OH  [I] wherein RF is a perfluoroalkyl group or a polyfluoroalkyl group in which some of the fluorine atoms of the perfluoroalkyl group are replaced by hydrogen atoms, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane with nano-silica particles, or fluorine-containing nano-silica composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF′-A-OH  [Ia] or the general formula: HO-A-RF″-A-OH  [Ib] wherein RF′ is a linear or branched perfluoroalkyl group containing an O, S, or N atom, RF″ is a linear or branched perfluoroalkylene group containing an O, S, or N atom, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane with nano-silica particles.

摘要翻译： 含氟的纳米二氧化硅复合颗粒包含由通式RF-A-OH [I]表示的含氟醇的缩合物，其中RF是全氟烷基或多氟烷基，其中一些氟原子 全氟烷基被氢原子代替，A是碳原子数为1〜6的亚烷基。 和具有纳米二氧化硅颗粒的烷氧基硅烷或由以下通式表示的含氟醇缩合物的含氟纳米二氧化硅复合颗粒：RF'-A-OH [Ia]或通式HO-A -RF“-A-OH [Ib]其中RF'是含有O，S或N原子的直链或支链全氟烷基，RF”是含有O，S或N原子的直链或支链全氟亚烷基， A是具有1-6个碳原子的亚烷基; 和具有纳米二氧化硅颗粒的烷氧基硅烷。