-
公开(公告)号:US07105356B2
公开(公告)日:2006-09-12
申请号:US09760213
申请日:2001-01-12
申请人: Magnus Malmqvist , H{dot over (a)}kan Roos , Stefan Sjölander , Mattias Tidare , H{dot over (a)}kan Sjödin , Ralph St{dot over (a)}lberg
发明人: Magnus Malmqvist , H{dot over (a)}kan Roos , Stefan Sjölander , Mattias Tidare , H{dot over (a)}kan Sjödin , Ralph St{dot over (a)}lberg
IPC分类号: G01N1/00
CPC分类号: G01N21/553 , B01J2219/00511 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0063 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01L3/502776 , B01L2200/0636 , B01L2200/12 , B01L2300/0636 , B01L2300/0877 , B82Y30/00 , G01N21/05 , G01N21/648 , G01N2021/0346 , G01N2021/058 , Y10S366/01 , Y10S366/03 , Y10T436/11 , Y10T436/117497 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.
摘要翻译: 提供了用于控制流动池内的感测表面上的流体流动的方法和装置。该方法采用层流技术将流体流动定位在流动池的感测表面上的一个或多个离散的感测区域上。 这样的方法允许离散感测区域的选择性敏化,并且提供离散感测区域与样品流体流的选择性接触。 将配体固定在离散的感测区域上,然后与包含在样品流体流中的分析物进行选择性接触,允许通过多种技术进行分析。 还提供敏感传感表面,传感器设备和系统。