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公开(公告)号：US20120283201A1
公开(公告)日：2012-11-08
申请号：US13547870
申请日：2012-07-12
Applicant: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
Inventor： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC: A61K31/65 , C07C275/40 , C07C271/30 , C07D307/81 , C07D333/24 , C07D317/60 , C07F9/40 , A61K31/662 , C07C311/21 , C07C255/60 , C07F7/10 , A61K31/695 , C07D295/155 , C07C275/54 , C07C335/20 , C07C311/05 , C07D213/56 , C07C279/18 , C07H15/203 , A61K31/7034 , A61P31/04 , A61P35/00 , C07D213/64 , C07C237/26
CPC classification number: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Abstract translation: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20100305149A1
公开(公告)日：2010-12-02
申请号：US12789047
申请日：2010-05-27
Applicant: Aleksandr Yurkovetskiy , Mao Yin , Gui Liu , Laura C. Akullian , John J. Kane , Cheri A. Stevenson , Charles E. Hammond , Russell C. Petter , John H. Van Duzer , Timothy B. Lowinger
Inventor： Aleksandr Yurkovetskiy , Mao Yin , Gui Liu , Laura C. Akullian , John J. Kane , Cheri A. Stevenson , Charles E. Hammond , Russell C. Petter , John H. Van Duzer , Timothy B. Lowinger
IPC: A61K31/439 , A61P35/00 , A61P35/04 , C07D487/18 , C07D491/22 , G01N33/50
CPC classification number: C07D519/04 , A61K47/59 , C07D491/22 , G01N2500/00 , Y10T436/145555
Abstract: Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
Abstract translation: 描述包含可变速率释放连接体的多价 - 药物共轭物以及制备这种缀合物的方法。 也描述了这种多种药物共轭物的用途。
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公开(公告)号：US08524214B2
公开(公告)日：2013-09-03
申请号：US12789047
申请日：2010-05-27
Applicant: Aleksandr Yurkovetskiy , Mao Yin , Gui Liu , Laura C. Akullian , John J. Kane , Cheri A. Stevenson , Charles E. Hammond , Russell C. Petter , John H. Van Duzer , Timothy B. Lowinger
Inventor： Aleksandr Yurkovetskiy , Mao Yin , Gui Liu , Laura C. Akullian , John J. Kane , Cheri A. Stevenson , Charles E. Hammond , Russell C. Petter , John H. Van Duzer , Timothy B. Lowinger
IPC: A61K31/045 , A61K31/04 , A61K31/13 , A61K31/21 , A61K31/33 , A61K31/695 , A61K31/765
CPC classification number: C07D519/04 , A61K47/59 , C07D491/22 , G01N2500/00 , Y10T436/145555
Abstract: Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
Abstract translation: 描述包含可变速率释放连接体的多价 - 药物共轭物以及制备这种缀合物的方法。 也描述了这种多种药物共轭物的用途。
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公开(公告)号：US20090325908A1
公开(公告)日：2009-12-31
申请号：US12351405
申请日：2009-01-09
Applicant: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
Inventor： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC: A61K31/65 , C07C237/26
CPC classification number: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Abstract translation: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US08048867B2
公开(公告)日：2011-11-01
申请号：US10839023
申请日：2004-05-04
Applicant: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
Inventor： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
IPC: A61K31/59 , C07C401/00
CPC classification number: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Abstract translation: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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Patent Agency Ranking
6.发明申请PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE BIOCOMPATIBLE CAMPTOTHECIN-POLYMER CONJUGATES 失效生物可降解生物活性聚合物共聚物的药物制剂公开(公告)号：US20100179181A1
公开(公告)日：2010-07-15
申请号：US12635027
申请日：2009-12-10
Applicant: James ROLKE , Russell C. PETTER , Mao YIN , Aleksandr YURKOVETSKIY , Gui LIU , Emile FARHAN
Inventor： James ROLKE , Russell C. PETTER , Mao YIN , Aleksandr YURKOVETSKIY , Gui LIU , Emile FARHAN
IPC: A61K31/4375 , A61K35/00
CPC classification number: A61K47/48215 , A61K31/44 , A61K47/59
Abstract: A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.
Abstract translation: 描述了在液体和冻干状态下稳定的喜树碱/聚合物双相药物释放系统。 聚合物含有缩醛和/或缩酮。
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公开(公告)号：US08635769B2
公开(公告)日：2014-01-28
申请号：US12621498
申请日：2009-11-19
Applicant: Chang Gui Liu
Inventor： Chang Gui Liu
CPC classification number: H05K1/181 , F21S4/24 , F21Y2115/10 , Y02P70/611 , Y10T29/49117 , Y10T29/49144 , Y10T29/49149
Abstract: A light strip includes a conductive plate including at least two first conductive strips, at least one column second conductive strips; first electric conductors including light sources soldered at said distance between said second conductive strips, second electric conductors soldered between said first conductive strips and said second conductive strips the light strip of the present invention not only has simple structures, but also has good stability.
Abstract translation: 光条包括导电板，该导电板包括至少两个第一导电条，至少一列第二导电条; 第一电导体，包括在所述第二导电条之间的所述距离处焊接的光源，焊接在所述第一导电条和所述第二导电条之间的第二导体，本发明的光条不仅具有简单的结构，而且具有良好的稳定性。
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8.发明申请PHARMACEUTICAL FORMULATIONS FOR FUMAGILLIN DERIVATIVE-PHF CONJUGATES 审中-公开FUMAGILLIN衍生物 - PHF结合物的药物制剂公开(公告)号：US20130189218A1
公开(公告)日：2013-07-25
申请号：US13725900
申请日：2012-12-21
Applicant: Laura Akullian , Gui Liu , Timothy B. Lowinger , Dennis McGillicuddy , Cheri Stevenson , John Van Duzer , Mao Yin , Aleksandr Yurkovetskiy
Inventor： Laura Akullian , Gui Liu , Timothy B. Lowinger , Dennis McGillicuddy , Cheri Stevenson , John Van Duzer , Mao Yin , Aleksandr Yurkovetskiy
IPC: A61K47/48
CPC classification number: A61K47/60 , C07D303/22
Abstract: The invention described herein provides a mixture comprising polymer molecules or salts thereof, wherein a polymer molecule in the mixture comprises covalently bound subunits L, K, and M wherein the average molecular weight of the polymer molecules in the mixture is about 50 kDa to about 200 kDa, wherein the mole percentage of subunit M, K and L, relative to the total amount of subunits in the mixture, is about 90.5 to about 96 mol %, about 2.8 to about 7.3 mol %, and about 1.2 to about 2.2 mol %, respectively.
Abstract translation: 本文描述的本发明提供了包含聚合物分子或其盐的混合物，其中该混合物中的聚合物分子包含共价结合的亚单位L，K和M，其中混合物中聚合物分子的平均分子量为约50kDa至约200 kDa，其中亚单位M，K和L相对于混合物中亚单位总量的摩尔百分比为约90.5至约96摩尔％，约2.8至约7.3摩尔％，约1.2至约2.2摩尔％ ， 分别。
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9.发明授权Pharmaceutical formulations of biodegradable biocompatible camptothecin-polymer conjugates 失效可生物降解的生物相容性喜树碱 - 聚合物共轭物的药物制剂公开(公告)号：US08491880B2
公开(公告)日：2013-07-23
申请号：US12635027
申请日：2009-12-10
Applicant: James Rolke , Russell C. Petter , Mao Yin , Aleksandr Yurkovetskiy , Gui Liu , Emile Farhan
Inventor： James Rolke , Russell C. Petter , Mao Yin , Aleksandr Yurkovetskiy , Gui Liu , Emile Farhan
IPC: A61K31/4375 , A61K35/00 , A61K39/00
CPC classification number: A61K47/48215 , A61K31/44 , A61K47/59
Abstract: A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.
Abstract translation: 描述了在液体和冻干状态下稳定的喜树碱/聚合物双相药物释放系统。 聚合物含有缩醛和/或缩酮。
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公开(公告)号：US20100214783A1
公开(公告)日：2010-08-26
申请号：US12621498
申请日：2009-11-19
Applicant: CHANG GUI LIU
Inventor： CHANG GUI LIU
CPC classification number: H05K1/181 , F21S4/24 , F21Y2115/10 , Y02P70/611 , Y10T29/49117 , Y10T29/49144 , Y10T29/49149
Abstract: A light strip includes a conductive plate including at least two first conductive strips, at least one column second conductive strips; first electric conductors including light sources soldered at said distance between said second conductive strips, second electric conductors soldered between said first conductive strips and said second conductive strips the light strip of the present invention not only has simple structures, but also has good stability.
Abstract translation: 光条包括导电板，该导电板包括至少两个第一导电条，至少一列第二导电条; 第一电导体，包括在所述第二导电条之间的所述距离处焊接的光源，焊接在所述第一导电条和所述第二导电条之间的第二导体，本发明的光条不仅具有简单的结构，而且具有良好的稳定性。
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