公开(公告)号：US20110020441A1

公开(公告)日：2011-01-27

申请号：US12808177

申请日：2008-12-12

Applicant: Jo Klaveness ,  Gry Stensrud ,  Aslak Godal ,  Jon Erik Braenden ,  Bjorn Klem

Inventor： Jo Klaveness ,  Gry Stensrud ,  Aslak Godal ,  Jon Erik Braenden ,  Bjorn Klem

IPC: A61K9/48 ,  A61K31/197 ,  A61K31/221 ,  A61K31/24 ,  A61K31/44 ,  A61P35/00

CPC classification number: A61K9/02 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/28 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/48 ,  A61K9/4858 ,  A61K9/4891 ,  A61K9/5042 ,  A61K9/5073 ,  A61K31/197 ,  A61K31/221 ,  A61K41/0057 ,  A61K41/0061 ,  A61K49/00 ,  A61K49/0021

Abstract: The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non-cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.

Abstract translation: 本发明涉及使用5-ALA或其前体或衍生物（例如ALA酯）的光敏剂在制造用于癌症的光动力学治疗或诊断的药物产品中，与 癌症或治疗或诊断非癌症状况，其中所述药物产品为固体形式。 本发明还涉及用于这些方法的固体药物产品，例如。 栓剂，阴道栓剂，片剂，丸剂和胶囊，其包含5-ALA或其前体或衍生物（例如ALA酯）和至少一种药学上可接受的载体或赋形剂。 这些产品特别适用于光动力学治疗或诊断胃肠系统下部或女性生殖系统中的癌性或非癌性病症。 在结直肠癌或宫颈癌的治疗或诊断中。

公开(公告)号：US20110008252A9

公开(公告)日：2011-01-13

申请号：US11721064

申请日：2005-10-14

Applicant: Ole Kristian Hjelstuen ,  Grethe Karin Martinussen ,  Gry Stensrud

Inventor： Ole Kristian Hjelstuen ,  Grethe Karin Martinussen ,  Gry Stensrud

IPC: A61K51/00 ,  A61P43/00

CPC classification number: A61K51/0497

Abstract: The present invention relates to stabilised 99mTc radiopharmaceutical compositions of the ligand tetrofosmin, which include an ascorbic acid or ascorbate radioprotectant, in the absence of an antimicrobial preservative. The invention also provides lyophilised kits suitable for the bulk preparation of multiple unit patient doses of 99mTc-tetrofosmin metal complexes. Also disclosed are unit doses of 99mTc-tetrofosmin, together with processes for preparing such unit doses from the lyophilised bulk vial.

Abstract translation: 本发明涉及在不存在抗微生物防腐剂的情况下，包括抗坏血酸或抗坏血酸盐放射防护剂的配体四氟吗啉的稳定化99mTc放射性药物组合物。 本发明还提供了适用于批量制备多单位患者剂量的99mTc-四替吗啉金属络合物的冻干试剂盒。 还公开了99mTc-四唑磷的单位剂量，以及从冻干的散装小瓶中制备这种单位剂量的方法。

公开(公告)号：US20120136055A1

公开(公告)日：2012-05-31

申请号：US13377722

申请日：2010-06-11

Applicant: Gry Stensrud

Inventor： Gry Stensrud

IPC: A61K31/221 ,  A61P35/00 ,  A61K31/197

CPC classification number: A61K31/221 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/195 ,  A61K41/0061 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26

Abstract: This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.

Abstract translation: 本发明涉及用于癌症的光动力学治疗（PDT），女性生殖系统，肛门和阴茎中的癌前病症和非癌症状态的半固体组合物和半固体药物产品，优选用于 在子宫内膜，子宫颈，外阴，阴道，肛门和阴茎发育异常和子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染的PDT中。 半固体组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。 本发明还涉及在雌性生殖系统，肛门和阴茎中的癌症的PDT，癌前病症和非癌症病症的方法，其中使用所述半固体组合物和药物产品。

公开(公告)号：US09694092B2

公开(公告)日：2017-07-04

申请号：US11721064

申请日：2005-10-14

Applicant: Ole Kristian Hjelstuen ,  Grethe Karin Martinussen ,  Gry Stensrud

Inventor： Ole Kristian Hjelstuen ,  Grethe Karin Martinussen ,  Gry Stensrud

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04

CPC classification number: A61K51/0497

Abstract: The present invention relates to stabilised 99mTc radiopharmaceutical compositions of the ligand tetrofosmin, which include an ascorbic acid or ascorbate radioprotectant, in the absence of an antimicrobial preservative. The invention also provides lyophilised kits suitable for the bulk preparation of multiple unit patient doses of 99mTc-tetrofosmin metal complexes. Also disclosed are unit doses of 99mTc-tetrofosmin, together with processes for preparing such unit doses from the lyophilised bulk vial.

公开(公告)号：US20120134921A1

公开(公告)日：2012-05-31

申请号：US13377692

申请日：2010-06-11

Applicant: Oddveig Sellaeg Helland ,  Gry Stensrud ,  Bjorn Klem ,  Jon Erik Braenden ,  Aslak Godal ,  Jo Klavenes

Inventor： Oddveig Sellaeg Helland ,  Gry Stensrud ,  Bjorn Klem ,  Jon Erik Braenden ,  Aslak Godal ,  Jo Klavenes

IPC: A61K51/04 ,  A61K49/00

CPC classification number: A61K31/197 ,  A61K9/0009 ,  A61K9/4858 ,  A61K41/0061 ,  A61K49/0036

Abstract: This invention relates to solid compositions and solid pharmaceutical products for use in methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions in the lower part of the gastrointestinal system. The solid pharmaceutical compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions of the lower gastrointestinal tract, wherein the solid pharmaceutical compositions and pharmaceutical products are used.

Abstract translation: 本发明涉及用于癌症的光动力学诊断方法，胃肠系统下部癌前和非癌症病症的固体组合物和固体药物产品。 固体药物组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。 本发明还涉及癌症的光动力学诊断方法，下胃肠道的癌前和非癌症状况，其中使用固体药物组合物和药物产品。

公开(公告)号：US20090311178A1

公开(公告)日：2009-12-17

申请号：US11721064

申请日：2005-10-14

Applicant: Ole Kristian Hjelstuen ,  Grethe Karin Martinussen ,  Gry Stensrud

Inventor： Ole Kristian Hjelstuen ,  Grethe Karin Martinussen ,  Gry Stensrud

IPC: A61K51/00 ,  A61P43/00

CPC classification number: A61K51/0497

Abstract: Compounds of formula (I) in salt or zwitterionic form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.