摘要:
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要:
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要:
The present invention provides a process for the preparation of a nonracemic a-amino acid derivative from an optically active N-acyl lactam using an organometallic reagent to effect the opening of the ring followed by reduction of the ketone carbonyl to an alcohol or a methylene, or by a reductive amination to an amine, or by a ketalization reaction.
摘要:
The invention relates to methods for preparing superporous hydrogels (SPH) that are very-pure and have desirable swelling properties necessary for commercial use, such as in food and pharmaceutical applications. Such methods include simultaneous use of low and high glass transition monomers to improve impurity and swelling profiles of the SPH, use of an integration means to prepare a very homogenous superporous hydrogel foam, washing the superporous hydrogel in a washing solution comprising different ratios of solvent to non-solvent (e.g., water/alcohol), use of a chemically-induced expansion/contraction process to enhance the efficiency of the multiple washing process and to fully structuralize the SPH, and employing one or more separation techniques, such as rubbing, filtration, centrifugation, compression and cutting to increase the efficiency of the purification process and to enhance the SPH swelling properties.
摘要:
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要:
A discharge-lamp control device for lighting a discharge-lamp includes two electrodes, first and second driving units to supply power to the discharge-lamp through the electrodes, respectively. Each driving unit includes a transformer having primary and secondary coils and a capacitor connected in parallel to the secondary coil. The first driving unit has impedance characteristics with a minimum impedance at a first frequency and a maximum impedance at a second frequency lower than the first frequency. The second driving unit has impedance characteristics having a minimum impedance at a third frequency and a maximum impedance at a fourth frequency lower than the third frequency. The first frequency is set to be higher than the third frequency. The second frequency is set to be lower than the fourth frequency. An operating frequency of the driving circuit is selected within a frequency bandwidth from the fourth frequency to the third frequency.
摘要:
Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H1 receptor antagonist.
摘要:
Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I.Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I.Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H. receptor antagonist.
摘要:
A process for signal detection in EDGE cellular systems is presented with the step of wireless channel estimation, a time-reversed signal processor, a soft-output Viterbi signal detector consisting of forward and reverse block processing, a MAP decoder that exchange soft information with the equalizer. Claim 1. A signal detection mechanism to demodulate received data frame that includes an accurate estimator to obtain channel responses, a forward filter and a FIR decision feedback filter to be used in soft-output equalizer, a time-reversal device storing received data in a time-reversed order for reverse block processing, an interference removal apparatus in both forward and reverse processing blocks, and a soft-input soft-output reduced state equalizer that utilizes the forward processing and reversed time processing blocks to generate iterative soft-output signals to the forward error correction decoder within the receiver system.
摘要:
A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH, an activated ester or the residue of a solid support having a plurality of amino functionalities; A is --O-- or --NH-- and Q is hydrogen or a protecting group for an amine or alcohol.