公开(公告)号：US12208372B2

公开(公告)日：2025-01-28

申请号：US16472747

申请日：2017-12-21

Applicant: GE HEALTHCARE LIMITED

Inventor： Nicolas Verbrugge ,  Xavier Y. A. Franci ,  Natthawadee Thawinwisan

IPC: B01J20/287 ,  B01D15/20 ,  B01D15/32 ,  C07B59/00

Abstract: The present invention relates to a method for conditioning reversed phase SPE cartridges that provides certain advantages compared with known such methods. The method of the invention finds particular use in the automated synthesis of radiolabeled compounds where SPE is used for example in the purification steps.

公开(公告)号：US20240350683A1

公开(公告)日：2024-10-24

申请号：US18569177

申请日：2022-06-16

Applicant: GE Healthcare Limited

Inventor： Graeme MCROBBIE ,  Torgrim ENGELL ,  Kristine WIKENE ,  Imtiaz Ahmed KHAN ,  Julian GRIGG ,  Alexander JACKSON ,  Alan CLARKE ,  Jonathan Robert SHALES

IPC: A61K51/12 ,  A61K47/22 ,  C07B59/00

CPC classification number: A61K51/121 ,  A61K47/22 ,  C07B59/004 ,  C07B2200/05

Abstract: Provided is a method of preparing an aqueous ascorbic acid solution having a pH of 2.0 to 4.0, the method comprising: providing an initial aqueous solution of ascorbic acid and a base, wherein the initial solution has a pH of 5.0 to 8.0; and combining the initial solution with a second acid to obtain an ascorbic acid solution having a pH of 2.0 to 4.0. Also provided is the use of an aqueous ascorbic acid solution having a pH of 2.0 to 4.0 prepared by a described method as a radiostabiliser of a radio-labelled compound.

公开(公告)号：US20230022430A1

公开(公告)日：2023-01-26

申请号：US17786383

申请日：2020-12-17

Applicant: GE HEALTHCARE LIMITED

Inventor： Graeme Walter MCROBBIE ,  Imtiaz Ahmed Khan ,  Jonathan Robert SHALES

IPC: B01L3/00

Abstract: The present invention provides a cassette for determining optimised solid phase extraction (SPE) purification conditions, wherein said cassette comprises: (i) a flowpath comprising a first end and a second end; and (ii) a plurality of valves oriented along said flowpath, wherein each of said plurality of valves is selectively fluidly connected to one of a number of components, wherein said components comprise: (a) 1-5 composition vials; (b) 1-3 SPE cartridges; (c) 4-10 solvent vials; (d) a water vial; and (e) a transfer line. The present invention also provides a method for determining optimised SPE purification conditions for a compound from a composition, the method comprising: (i) provision of a cassette as defined in any of claims 1 to 7; (ii) the cassette comprising a composition of the compound in said composition vial(s) or addition of such a composition to said crude reaction vial(s); (iii) passing an aliquot of said composition into each of said 1-3 SPE cartridges; (iv) passing a particular combination of aliquots of solvent from at least 4 of said 4-10 solvent vials into one or more of the SPE cartridges, wherein the solvent in each of said 4-10 solvent vials is either a different solvent or the same solvent at different concentration; (v) eluting the compound to be purified from the or each SPE cartridge; (vi) evaluating the eluted products of step (v); and (vii) determining the optimised purification conditions by comparing the eluted products of step (v) from each cartridge and each solvent.

公开(公告)号：US11534494B2

公开(公告)日：2022-12-27

申请号：US16997188

申请日：2020-08-19

Applicant: GE Healthcare Limited

Inventor： Knut Richard Dyrstad ,  Torild Wickstrom ,  Thanushan Rajanayagam ,  Kristine Romoren ,  Olav Ryan

IPC: A61K51/00 ,  A61M36/14 ,  A61K47/12 ,  A61K51/04

Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.

公开(公告)号：US11135322B2

公开(公告)日：2021-10-05

申请号：US14373413

申请日：2013-01-22

Applicant: GE HEALTHCARE LIMITED ,  UNIVERSITY OF SOUTHAMPTON

Inventor： Rajiv Bhalla ,  Sajinder Kaur Luthra ,  Gill Reid, I ,  William Levason

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  A61K51/04

Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.

公开(公告)号：US10759747B2

公开(公告)日：2020-09-01

申请号：US16097571

申请日：2017-05-02

Applicant: GE HEALTHCARE LIMITED ,  KING'S COLLEGE LONDON

Inventor： Imtiaz Khan ,  Graeme McRobbie ,  Anna Kirjavainen

IPC: C07C319/14

Abstract: The present invention relates to a method of radiochemical synthesis. Novel methods useful in the synthesis of a positron emission tomography (PET) tracer, and novel intermediates useful in said method are provided that have advantages over known methods.

公开(公告)号：US20200234400A1

公开(公告)日：2020-07-23

申请号：US16841329

申请日：2020-04-06

Applicant: GE HEALTHCARE LIMITED

Inventor： Roger Lundqvist ,  Nils Lennart Thurfjell ,  Johan Lilja

IPC: G06T3/00 ,  A61B6/03 ,  A61B6/00 ,  G06T7/33

Abstract: An adaptive template image for registering a PET or a SPECT image includes a template image model including variability of values for each voxel in a template image according to one or more control parameters.

公开(公告)号：US10709798B2

公开(公告)日：2020-07-14

申请号：US14648353

申请日：2013-11-28

Applicant: GE Healthcare Limited

Inventor： Sondre Nilsen ,  Srinath Balaji Aralikatti Prahladachar Balaji ,  Umamaheshwar P. Mokkapati ,  Afsal Mohammed Kadavilpparampu Mohamed

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  C07D209/88

Abstract: A composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties, particularly when said compound is destined for use in vivo as a therapeutic or diagnostic agent.

公开(公告)号：US20190275182A1

公开(公告)日：2019-09-12

申请号：US16375223

申请日：2019-04-04

Applicant: GE Healthcare Limited

Inventor： Torgrim ENGELL ,  Gareth Simon GETVOLDSEN ,  Andreas Richard MEIJER ,  Imtiaz Ahmed KHAN ,  Graeme MCROBBIE ,  Robert James NAIRNE

IPC: A61K51/08 ,  C07B59/00 ,  A61K51/04

Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.

公开(公告)号：US10315179B2

公开(公告)日：2019-06-11

申请号：US15546988

申请日：2016-03-16

Applicant: GE Healthcare Limited

Inventor： Philippe Dumont

IPC: B01J19/00 ,  C07B59/00

Abstract: The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.