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公开(公告)号：US20140377178A1
公开(公告)日：2014-12-25
申请号：US14373413
申请日：2013-01-22
Applicant: GE HEALTHCARE LIMITED , UNIVERSITY OF SOUTHAMPTON
Inventor： Rajiv Bhalla , Sajinder Kaur Luthra , Gill Reid, I , William Levason
IPC: A61K51/08
CPC classification number: A61K51/08 , A61K51/0482 , A61K51/082 , A61K51/085
Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
Abstract translation: 本发明涉及通过将氟连接到非放射性金属的大环金属络合物，其中金属络合物与生物分子结合的方法，用18F标记生物分子。 还提供了药物组合物，试剂盒和体内成像方法。
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公开(公告)号：US11135322B2
公开(公告)日：2021-10-05
申请号：US14373413
申请日：2013-01-22
Applicant: GE HEALTHCARE LIMITED , UNIVERSITY OF SOUTHAMPTON
Inventor： Rajiv Bhalla , Sajinder Kaur Luthra , Gill Reid, I , William Levason
Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
