公开(公告)号：US20110091378A1

公开(公告)日：2011-04-21

申请号：US12670179

申请日：2008-07-21

申请人： Paul Dudas ,  Sarah Sague ,  Merle M. Elloso ,  Francis Farrell

发明人： Paul Dudas ,  Sarah Sague ,  Merle M. Elloso ,  Francis Farrell

IPC分类号： A61K51/10 ,  A61K38/16 ,  A61K38/02 ,  A61K39/395 ,  A61P37/02 ,  A61P9/00 ,  A61P25/00

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates methods and compositions for treating interleukin-17 (IL-17) related conditions, such as IL-17A or IL-17F, or muteins thereof in patients having fibrosis using IL-17 antagonists, such as small molecule IL-17 antagonists or protein IL-17 antagonists, such as antibodies, including specified portions or variants, specific for at least one IL-17 protein, mutein or fragment thereof, including therapeutic formulations, administration and devices.

摘要翻译： 本发明涉及使用IL-17拮抗剂（例如小分子IL-17）治疗患有纤维化的患者中的白细胞介素-17（IL-17）相关病症如IL-17A或IL-17F或其突变蛋白的方法和组合物 拮抗剂或蛋白质IL-17拮抗剂，例如对于至少一种IL-17蛋白，突变蛋白或其片段特异性的包括特定部分或变体的抗体，包括治疗剂型，给药和装置。

公开(公告)号：US1174113A

公开(公告)日：1916-03-07

申请号：US1914873629

申请日：1914-11-23

申请人： JOHN FRANCIS FARRELL ,  BEATTY ALBERT HENRY CLAY

发明人： BEATTY ALBERT HENRY CLAY

CPC分类号： F24C5/02

公开(公告)号：US08581269B2

公开(公告)日：2013-11-12

申请号：US13576837

申请日：2010-02-10

申请人： Sola Anne Kuk ,  Yong Wang ,  James Francis Farrell

发明人： Sola Anne Kuk ,  Yong Wang ,  James Francis Farrell

IPC分类号： H01L33/00

CPC分类号： B41J2/45 ,  F21K9/00 ,  H01L25/0753 ,  H01L2924/0002 ,  H01L2924/00

摘要： A modular LED array light source comprises an assembly of a plurality of solid-state LED array modules. Modules are abutted to provide a large area, high intensity and high-density array that provides substantially uniform irradiance. Preferably, in each module, a linear or rectangular array of groups of LED is provided in which the density of LED die in the array is higher at ends or edges of the modules abutting other modules, to provide improved uniformity of irradiance over the illuminated area between modules. Particular arrangements of clusters of LEDs are provided that reduce or overcome the discontinuity or dip in irradiance due to edge or wall effects caused by the spacing of LED die from edges of the substrate/packaging of each module. These arrangements are advantageous for hermetically sealed LED array modules, for example, which require a minimum wall thickness for an effective seal.

摘要翻译： 模块化LED阵列光源包括多个固态LED阵列模块的组件。 模块抵靠以提供大面积，高强度和高密度阵列，其提供基本均匀的辐照度。 优选地，在每个模块中，提供LED组的线性或矩形阵列，其中阵列中的LED管芯的密度在与其他模块相邻的模块的端部或边缘处较高，以提供在照射区域上的改善的辐照度均匀性 模块之间。 提供了LED簇的特殊布置，其减少或克服了由于LED芯片与每个模块的基板/封装的边缘的间隔引起的边缘或壁面影响的不连续性或浸入辐照度。 这些布置对于密封的LED阵列模块是有利的，例如，其需要用于有效密封的最小壁厚。

公开(公告)号：US20090170759A1

公开(公告)日：2009-07-02

申请号：US11776003

申请日：2007-07-11

申请人： Virginia Smith-Swintosky ,  Michael Renzi ,  Carlos Plata-Salaman ,  Linda Jolliffe ,  Francis Farrell ,  Dana Johnson

发明人： Virginia Smith-Swintosky ,  Michael Renzi ,  Carlos Plata-Salaman ,  Linda Jolliffe ,  Francis Farrell ,  Dana Johnson

IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  C12N5/06

CPC分类号： A61K38/1816 ,  A61K47/60 ,  C07K14/505

摘要： Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that have the full range of biological activity of human erythropoietin or only certain biological activities of erythropoietin. Improved therapeutic regimens where the erythropoietin is administered at concentrations below those required to stimulate hematopoiesis are also provided.

摘要翻译： 公开了通过施用具有人促红细胞生成素神经学治疗活性的组合物治疗神经系统疾病的方法。 这些组合物包括治疗剂，例如肽，肽二聚体，多肽和蛋白质，其具有人类促红细胞生成素的全部生物学活性或只有促红细胞生成素的某些生物学活性。 还提供了改善的促红细胞生成素以低于刺激造血所需浓度的浓度给药的治疗方案。

公开(公告)号：US20090162375A1

公开(公告)日：2009-06-25

申请号：US11924108

申请日：2007-10-25

申请人： Simon Blake ,  Jill Carton ,  Jennifer Henrica Lee ,  Keying Ma ,  Paul Marsters ,  Kristen Picha ,  Xiao-Yu R. Song ,  Francis Farrell ,  Lynne Murray ,  Alexey Teplyakov ,  Tatiana Ort

发明人： Simon Blake ,  Jill Carton ,  Jennifer Henrica Lee ,  Keying Ma ,  Paul Marsters ,  Kristen Picha ,  Xiao-Yu R. Song ,  Francis Farrell ,  Lynne Murray ,  Alexey Teplyakov ,  Tatiana Ort

IPC分类号： A61K39/395 ,  C07K16/26 ,  C07K7/08 ,  C07H21/00 ,  C12Q1/02

CPC分类号： C07K16/26 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.

摘要翻译： 公开了抗性拮抗剂，包括与限定的表位反应的抗体。 还公开了可用于提高抗人抵抗素抗体的抗原。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。 还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。 进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。

公开(公告)号：US20080170918A1

公开(公告)日：2008-07-17

申请号：US11858425

申请日：2007-09-20

申请人： James Francis Farrell

发明人： James Francis Farrell

IPC分类号： B23P15/28

CPC分类号： B23B27/1677 ,  B23B2260/106 ,  B23B2260/124

摘要： The present invention provides a toolholder mountable on a lathe or other machine tool for supporting a cutting plate relative to a workpiece for cutting or shaping the workpiece. The toolholder including a body having a tapered tool base at one end thereof, the tool base defining a tool seat for supporting a cutting plate. A plug screw having a head defining threads on an outer surface thereof for engaging a threaded hole in the tool base is also provided. The plug screw further defining a shank extending eccentrically from the head, the shank being receivable through a mounting hole defined by the cutting plate for locating the cutting plate relative to the tool seat upon rotation of the plug screw relative to the tool base. A lock nut is provided for receiving a threaded end of the shank for securing the cutting plate to the tool base and toolholder.

摘要翻译： 本发明提供了可安装在车床或其它机床上的刀架，用于相对于工件支撑切割板以切割或成形工件。 刀架包括在其一端具有锥形工具基座的主体，工具基座限定用于支撑切割板的工具座。 还提供一种插头螺钉，其具有在其外表面上限定螺纹的头，用于接合工具基座中的螺纹孔。 所述插头螺钉进一步限定从所述头部偏心延伸的柄部，所述柄部可接收通过由所述切割板限定的安装孔，用于当所述插头螺钉相对于所述工具基座旋转时相对于所述工具座定位所述切割板。 锁紧螺母被设置成用于容纳柄的螺纹端，用于将切割板固定到刀架和刀架上。

公开(公告)号：US20070015701A1

公开(公告)日：2007-01-18

申请号：US11444598

申请日：2006-05-31

申请人： Samuel Zalipsky ,  Francis Farrell ,  Beth Hill ,  Radwan Kiwan

发明人： Samuel Zalipsky ,  Francis Farrell ,  Beth Hill ,  Radwan Kiwan

IPC分类号： A61K38/18

CPC分类号： A61K38/1875 ,  A61K47/60

摘要： A modified bone morphogenetic protein (BMP, also referred to as bone morphogenic protein) composition is described. The bone morphogenetic protein, in one embodiment, is BMP-7 which is chemically modified with a hydrophilic polymer, such as poly(ethylene glycol).

摘要翻译： 描述了修饰的骨形态发生蛋白（BMP，也称为骨形态发生蛋白）组合物。 在一个实施方案中，骨形态发生蛋白是BMP-7，其用亲水性聚合物如聚（乙二醇）化学改性。

公开(公告)号：US20070009967A1

公开(公告)日：2007-01-11

申请号：US11530222

申请日：2006-09-08

申请人： Michael RENZI ,  Navneeth Thirumalai ,  Linda Jolliffe ,  Francis Farrell

发明人： Michael RENZI ,  Navneeth Thirumalai ,  Linda Jolliffe ,  Francis Farrell

IPC分类号： G01N33/567 ,  G01N33/53

CPC分类号： G01N33/573 ,  A61K31/00 ,  A61K31/381 ,  A61K31/426 ,  A61K31/427 ,  A61K38/1816 ,  C12Q1/44 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

摘要： The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.

公开(公告)号：US4031238A

公开(公告)日：1977-06-21

申请号：US582391

申请日：1975-05-30

申请人： Joanne Reid ,  Elpidio Leoncio DE LA Teja ,  Francis Farrell

发明人： Joanne Reid ,  Elpidio Leoncio DE LA Teja ,  Francis Farrell

IPC分类号： A23F3/32 ,  A23L2/395 ,  A23L2/38 ,  A23F3/00

CPC分类号： A23L2/395 ,  A23F3/32

摘要： A water-soluble solid beverage cube, consisting of powdered glucose monohydrate, sucrose and hygroscopic flavor material, is prepared by mixing the ingredients, heating them above 95.degree. F in a high humidity atmosphere, shaping the solidified mass and allowing the solid to cool. Additives may be added to the powdered mixture to increase the strength of the solid, improve its hygroscopic nature and alter its taste.

摘要翻译： 通过混合成分，在高湿度环境下将其加热至95°F以上，将固化的物料整形并使固体冷却，制备由葡萄糖一水合物，蔗糖和吸湿风味材料组成的水溶性固体饮料立方体。 添加剂可以添加到粉末混合物中以增加固体的强度，改善其吸湿性质并改变其味道。

公开(公告)号：US20100183620A1

公开(公告)日：2010-07-22

申请号：US12626534

申请日：2009-11-25

申请人： KAUMUDI BHAWE ,  Elizabeth Bosch ,  Kathleen Boyle ,  Arthur Brace ,  Anuk Das ,  Francis Farrell ,  Pitchumani Sivakumar ,  Jeffrey Finer ,  Kristen Pierce ,  Kathleen M. Sullivan ,  Brian Wong

发明人： KAUMUDI BHAWE ,  Elizabeth Bosch ,  Kathleen Boyle ,  Arthur Brace ,  Anuk Das ,  Francis Farrell ,  Pitchumani Sivakumar ,  Jeffrey Finer ,  Kristen Pierce ,  Kathleen M. Sullivan ,  Brian Wong

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/16 ,  A61P21/00 ,  C12Q1/68

CPC分类号： C07K14/811 ,  A61K38/57 ,  C07K16/38 ,  C07K2317/76

摘要： The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.

摘要翻译： 本发明包括使用SERPINE2和SERPINE2拮抗剂增加或减少肺成纤维细胞中胶原1A1表达和/或α-平滑肌肌动蛋白表达的方法和组合物。 本发明还包括用于增加或减少肌成纤维细胞形成的方法和组合物。 本发明进一步提供了治疗肺部疾病如特发性肺纤维化和慢性阻塞性肺疾病的方法和组合物。