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公开(公告)号:US08663980B2
公开(公告)日:2014-03-04
申请号:US12738453
申请日:2008-10-24
申请人: Jill Carton , Jin Lu , Bernard J. Scallon , Linda Snyder
发明人: Jill Carton , Jin Lu , Bernard J. Scallon , Linda Snyder
CPC分类号: C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2319/036 , C12N15/85 , C12N2800/22
摘要: Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and promoter sequences that can be varied to interact with transcription factors in the host cell and thereby control transcription of the antibody-encoding DNA. A kit can incorporate these vectors and plasmids.
摘要翻译: 抗体表达载体和质粒可以掺入用于转录抗体DNA的各种抗体基因部分和抗体在合适的宿主细胞中的表达。 表达载体和质粒具有有利于将抗体编码DNA连接到载体中的限制酶位点。 载体包含增强子和启动子序列,其可以变化以与宿主细胞中的转录因子相互作用,从而控制抗体编码DNA的转录。 试剂盒可以并入这些载体和质粒。
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公开(公告)号:US07982007B2
公开(公告)日:2011-07-19
申请号:US12342332
申请日:2008-12-23
申请人: Heena Beck , Jill Carton
发明人: Heena Beck , Jill Carton
CPC分类号: C07K14/705 , G01N33/5088
摘要: Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed.
摘要翻译: 公开了编码食蟹猴Toll样受体3(cynoTLR3)的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,重组细胞,这些的方法和用途。
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公开(公告)号:US20090176238A1
公开(公告)日:2009-07-09
申请号:US12342332
申请日:2008-12-23
申请人: Heena Beck , Jill Carton
发明人: Heena Beck , Jill Carton
IPC分类号: C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/705 , C12Q1/02 , C12Q1/00 , C07K16/18 , A61K49/00
CPC分类号: C07K14/705 , G01N33/5088
摘要: Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed.
摘要翻译: 公开了编码食蟹猴Toll样受体3(cynoTLR3)的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,重组细胞,这些的方法和用途。
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公开(公告)号:US20090162375A1
公开(公告)日:2009-06-25
申请号:US11924108
申请日:2007-10-25
申请人: Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人: Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号: A61K39/395 , C07K16/26 , C07K7/08 , C07H21/00 , C12Q1/02
CPC分类号: C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译: 公开了抗性拮抗剂,包括与限定的表位反应的抗体。 还公开了可用于提高抗人抵抗素抗体的抗原。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性(包括间质性肺病,肥大性瘢痕形成,瘢痕疙瘩瘢痕形成和硬皮病)的疾病症状的方法。 还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。 进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。
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公开(公告)号:US09353181B2
公开(公告)日:2016-05-31
申请号:US13524122
申请日:2012-06-15
申请人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号: A61K39/395 , C07K16/24 , A61K39/00
CPC分类号: C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 人抗IL-23p19抗体,包括编码至少一种抗IL-23p19抗体的分离的核酸,载体,宿主细胞及其制备和使用方法在诊断和/或治疗组合物,方法和装置中的应用 。
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公开(公告)号:US08106177B2
公开(公告)日:2012-01-31
申请号:US13079457
申请日:2011-04-04
申请人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号: C07H21/04
CPC分类号: C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 人抗IL-23p19抗体,包括编码至少一种抗IL-23p19抗体的分离的核酸,载体,宿主细胞及其制备和使用方法在诊断和/或治疗组合物,方法和装置中的应用 。
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公开(公告)号:US07935344B2
公开(公告)日:2011-05-03
申请号:US11617503
申请日:2006-12-28
申请人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 人抗IL-23p19抗体,包括编码至少一种抗IL-23p19抗体的分离的核酸,载体,宿主细胞及其制备和使用方法在诊断和/或治疗组合物,方法和装置中的应用 。
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公开(公告)号:US20090117122A1
公开(公告)日:2009-05-07
申请号:US12233683
申请日:2008-09-19
申请人: Jill Carton , Francis Farrell , Lynne Murray , Tatiana Ort , Alexey Teplyakov
发明人: Jill Carton , Francis Farrell , Lynne Murray , Tatiana Ort , Alexey Teplyakov
IPC分类号: A61K39/395 , C07K16/18 , C07K7/08 , C07H21/00
CPC分类号: C07H21/04 , A61K2039/505 , C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Antigens useful for raising antibodies against human resistin are also disclosed.
摘要翻译: 公开了抗性拮抗剂,包括与限定的表位反应的抗体。 还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性(包括间质性肺病,肥大性瘢痕形成,瘢痕疙瘩瘢痕形成和硬皮病)的疾病症状的方法。 还公开了可用于提高抗人抵抗素抗体的抗原。
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公开(公告)号:US07993645B2
公开(公告)日:2011-08-09
申请号:US12855354
申请日:2010-08-12
申请人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人: Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号:US20110008321A1
公开(公告)日:2011-01-13
申请号:US12738453
申请日:2008-10-24
申请人: Jill Carton , Jin Lu , Bernard J. Scallon , Linda Snyder
发明人: Jill Carton , Jin Lu , Bernard J. Scallon , Linda Snyder
CPC分类号: C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2319/036 , C12N15/85 , C12N2800/22
摘要: Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and promoter sequences that can be varied to interact with transcription factors in the host cell and thereby control transcription of the antibody-encoding DNA. A kit can incorporate these vectors and plasmids.
摘要翻译: 抗体表达载体和质粒可以掺入用于转录抗体DNA的各种抗体基因部分和抗体在合适的宿主细胞中的表达。 表达载体和质粒具有有利于将抗体编码DNA连接到载体中的限制酶位点。 载体包含增强子和启动子序列,其可以变化以与宿主细胞中的转录因子相互作用,从而控制编码抗体的DNA的转录。 试剂盒可以并入这些载体和质粒。
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