公开(公告)号：US10987322B2

公开(公告)日：2021-04-27

申请号：US15315071

申请日：2015-06-05

Applicant: FLEXUS BIOSCIENCES, INC.

Inventor： Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky

IPC: A61K31/15 ,  C07D295/155 ,  C07D213/58 ,  C07D307/16 ,  A61K45/06 ,  C07C259/12 ,  C07D211/62 ,  C07D277/56 ,  A61K31/4409 ,  A61K31/167 ,  A61K31/196 ,  A61K31/24 ,  A61K31/27 ,  A61K31/341 ,  A61K31/40 ,  A61K31/426 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/5375 ,  C07C259/14 ,  C07C271/28 ,  C07D207/09 ,  C07D211/34 ,  C07D277/30

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US20220274926A1

公开(公告)日：2022-09-01

申请号：US17552517

申请日：2021-12-16

Applicant: FLEXUS BIOSCIENCES, INC.

Inventor： Hilary Plake BECK ,  Juan Carlos JAEN ,  Maksim OSIPOV ,  Jay Patrick POWERS ,  Maureen Kay REILLY ,  Hunter Paul SHUNATONA ,  James Ross WALKER ,  Mikhail ZIBINSKY ,  James Aaron BALOG ,  David K. WILLIAMS ,  Weiwei GUO

IPC: C07D213/75 ,  A61K45/06 ,  A61K31/167 ,  C07C255/60 ,  C07C317/40 ,  C07D239/42 ,  C07C233/15 ,  C07D295/155 ,  C07C233/29 ,  C07C237/22 ,  C07C233/66 ,  C07D213/56 ,  C07C321/28 ,  C07D295/15 ,  C07C235/26 ,  A61K31/195 ,  C07C255/57 ,  C07C235/38 ,  C07D207/27 ,  C07D231/12 ,  C07C317/44 ,  C07C237/20 ,  C07D309/06 ,  C07D309/04 ,  C07C235/36 ,  C07D317/46 ,  C07D277/30 ,  A61K31/426 ,  A61K39/39 ,  A61P35/00 ,  A61P37/06 ,  A61K31/277 ,  A61K31/343 ,  A61K31/44 ,  A61K31/505 ,  A61K31/5375 ,  C07C233/11 ,  C07C233/28 ,  C07C323/41 ,  C07D317/66

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US09643972B2

公开(公告)日：2017-05-09

申请号：US14933863

申请日：2015-11-05

Applicant: Flexus Biosciences, Inc.

Inventor： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Emily Charlotte Cherney ,  Weifang Shan ,  Audris Huang

IPC: A61K31/4709 ,  C07D487/04 ,  C07D215/06 ,  A61K31/47 ,  C07D231/56 ,  A61K31/416 ,  C07D215/233 ,  C07D471/04 ,  A61K31/437 ,  C07D239/74 ,  A61K31/517 ,  A61K31/4375 ,  C07D217/04 ,  C07D405/08 ,  C07D417/08 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K31/496 ,  A61K31/519 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  C07D215/06 ,  C07D215/14 ,  C07D215/233 ,  C07D217/04 ,  C07D231/56 ,  C07D239/74 ,  C07D401/12 ,  C07D401/14 ,  C07D405/08 ,  C07D405/12 ,  C07D417/08 ,  C07D417/12 ,  C07D471/04

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US10533014B2

公开(公告)日：2020-01-14

申请号：US16123912

申请日：2018-09-06

Applicant: Flexus Biosciences, Inc.

Inventor： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Emily Charlotte Cherney ,  Weifang Shan ,  Audris Huang

IPC: C07D487/04 ,  A61K31/47 ,  C07D215/06 ,  C07D231/56 ,  A61K31/416 ,  C07D215/233 ,  C07D471/04 ,  A61K31/437 ,  C07D239/74 ,  A61K31/517 ,  A61K31/4375 ,  C07D217/04 ,  C07D405/08 ,  A61K31/4709 ,  C07D417/08 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K31/496 ,  A61K31/519 ,  A61K45/06 ,  C07D215/14 ,  C07D405/12 ,  C07D417/12 ,  A61P35/02 ,  C07D215/12 ,  C07D217/12 ,  C07D217/24 ,  A61K39/395

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US20190092729A1

公开(公告)日：2019-03-28

申请号：US15524113

申请日：2015-11-05

Applicant: FLEXUS BIOSCIENCES, INC.

Inventor： Hilary Plake BECK ,  Juan Carlos JAEN ,  Maksim OSIPOV ,  Jay Patrick POWERS ,  Maureen Kay REILLY ,  Hunter Paul SHUNATONA ,  James Ross WALKER ,  Mikhail ZIBINSKY ,  James Aaron BALOG ,  David K. WILLIAMS ,  Weiwei GUO

IPC: C07D213/75 ,  A61K31/44 ,  C07D239/42 ,  A61K31/505 ,  C07C233/28 ,  A61K31/167 ,  C07C233/15 ,  C07C233/11 ,  C07C255/60 ,  A61K31/277 ,  C07D317/66 ,  A61K31/343 ,  C07C323/41 ,  C07C317/40 ,  A61K45/06 ,  C07D295/155 ,  A61K31/5375 ,  A61P37/06

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US09598422B2

公开(公告)日：2017-03-21

申请号：US14933879

申请日：2015-11-05

Applicant: Flexus Biosciences, Inc.

Inventor： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Steven P. Seitz ,  Emily Charlotte Cherney ,  Liping Zhang ,  Weifang Shan ,  Weiwei Guo ,  Audris Huang

IPC: C07C255/50 ,  A61K31/277 ,  C07C233/65 ,  C07D487/04 ,  A61K31/166 ,  C07D211/08 ,  A61K31/445 ,  C07C211/45 ,  A61K31/136 ,  C07D215/04 ,  A61K31/47 ,  A61K31/4709 ,  C07D215/233 ,  C07D213/68 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/00

CPC classification number: A61K31/166 ,  A61K31/00 ,  A61K31/136 ,  A61K31/277 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US11932601B2

公开(公告)日：2024-03-19

申请号：US17552517

申请日：2021-12-16

Applicant: FLEXUS BIOSCIENCES, INC.

Inventor： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Weiwei Guo

IPC: C07D213/75 ,  A61K31/167 ,  A61K31/195 ,  A61K31/277 ,  A61K31/343 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61K31/5375 ,  A61K39/39 ,  A61K45/06 ,  A61P35/00 ,  A61P37/06 ,  C07C233/11 ,  C07C233/15 ,  C07C233/28 ,  C07C233/29 ,  C07C233/66 ,  C07C235/26 ,  C07C235/36 ,  C07C235/38 ,  C07C237/20 ,  C07C237/22 ,  C07C255/57 ,  C07C255/60 ,  C07C317/40 ,  C07C317/44 ,  C07C321/28 ,  C07C323/41 ,  C07D207/27 ,  C07D213/56 ,  C07D231/12 ,  C07D239/42 ,  C07D277/30 ,  C07D295/15 ,  C07D295/155 ,  C07D309/04 ,  C07D309/06 ,  C07D317/46 ,  C07D317/66 ,  A61K39/00

CPC classification number: C07D213/75 ,  A61K31/167 ,  A61K31/195 ,  A61K31/277 ,  A61K31/343 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61K31/5375 ,  A61K39/39 ,  A61K45/06 ,  A61P35/00 ,  A61P37/06 ,  C07C233/11 ,  C07C233/15 ,  C07C233/28 ,  C07C233/29 ,  C07C233/66 ,  C07C235/26 ,  C07C235/36 ,  C07C235/38 ,  C07C237/20 ,  C07C237/22 ,  C07C255/57 ,  C07C255/60 ,  C07C317/40 ,  C07C317/44 ,  C07C321/28 ,  C07C323/41 ,  C07D207/27 ,  C07D213/56 ,  C07D231/12 ,  C07D239/42 ,  C07D277/30 ,  C07D295/15 ,  C07D295/155 ,  C07D309/04 ,  C07D309/06 ,  C07D317/46 ,  C07D317/66 ,  A61K2039/55511 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  Y02A50/30 ,  A61K31/167 ,  A61K2300/00 ,  A61K31/195 ,  A61K2300/00 ,  A61K31/426 ,  A61K2300/00

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US11242319B2

公开(公告)日：2022-02-08

申请号：US15524113

申请日：2015-11-05

Applicant: FLEXUS BIOSCIENCES, INC.

Inventor： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Weiwei Guo

IPC: C07D213/75 ,  A61K45/06 ,  A61K31/167 ,  C07C255/60 ,  C07C317/40 ,  C07D239/42 ,  C07C233/15 ,  C07D295/155 ,  C07C233/29 ,  C07C237/22 ,  C07C233/66 ,  C07D213/56 ,  C07C321/28 ,  C07D295/15 ,  C07C235/26 ,  A61K31/195 ,  C07C255/57 ,  C07C235/38 ,  C07D207/27 ,  C07D231/12 ,  C07C317/44 ,  C07C237/20 ,  C07D309/06 ,  C07D309/04 ,  C07C235/36 ,  C07D317/46 ,  C07D277/30 ,  A61K31/426 ,  A61K39/39 ,  A61P35/00 ,  A61P37/06 ,  A61K31/277 ,  A61K31/343 ,  A61K31/44 ,  A61K31/505 ,  A61K31/5375 ,  C07C233/11 ,  C07C233/28 ,  C07C323/41 ,  C07D317/66 ,  A61K39/00

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US10106546B2

公开(公告)日：2018-10-23

申请号：US15469707

申请日：2017-03-27

Applicant: Flexus Biosciences, Inc.

Inventor： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Emily Charlotte Cherney ,  Weifang Shan ,  Audris Huang

IPC: A61K31/47 ,  C07D487/04 ,  C07D215/06 ,  C07D231/56 ,  A61K31/416 ,  C07D215/233 ,  C07D471/04 ,  A61K31/437 ,  C07D239/74 ,  A61K31/517 ,  A61K31/4375 ,  C07D217/04 ,  C07D405/08 ,  A61K31/4709 ,  C07D417/08 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K31/496 ,  A61K31/519 ,  A61K45/06 ,  C07D215/14 ,  C07D405/12 ,  C07D417/12

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US20180282281A1

公开(公告)日：2018-10-04

申请号：US15524396

申请日：2015-11-05

Applicant: FLEXUS BIOSCIENCES, INC.

Inventor： Hilary Plake BECK ,  Juan Carios JAEN ,  Maksim OSIPOV ,  Jay Patrick POWERS ,  Maureen Kay REILLY ,  Hunter Paul SHUNATONA ,  James Ross WALKER ,  Mikhail ZIBINSKY ,  James Aaron BALOG ,  David K. WILLIAMS ,  Jay A. MARKWALDER ,  Emily Charlotte CHERNEY ,  Welfang SHAN ,  Audris HUANG

IPC: C07D215/12 ,  C07D215/233 ,  C07D217/12 ,  C07D217/24 ,  C07D231/56 ,  C07D239/74 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  A61P35/02

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.