公开(公告)号：US20180282281A1

公开(公告)日：2018-10-04

申请号：US15524396

申请日：2015-11-05

申请人： FLEXUS BIOSCIENCES, INC.

发明人： Hilary Plake BECK ,  Juan Carios JAEN ,  Maksim OSIPOV ,  Jay Patrick POWERS ,  Maureen Kay REILLY ,  Hunter Paul SHUNATONA ,  James Ross WALKER ,  Mikhail ZIBINSKY ,  James Aaron BALOG ,  David K. WILLIAMS ,  Jay A. MARKWALDER ,  Emily Charlotte CHERNEY ,  Welfang SHAN ,  Audris HUANG

IPC分类号： C07D215/12 ,  C07D215/233 ,  C07D217/12 ,  C07D217/24 ,  C07D231/56 ,  C07D239/74 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04 ,  A61P35/02

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US20180325889A1

公开(公告)日：2018-11-15

申请号：US15524092

申请日：2015-11-05

申请人： FLEXUS BIOSCIENCES, INC.

发明人： Hilary Plake BECK ,  Juan Carlos JAEN ,  Maksim OSIPOV ,  Jay Patrick POWERS ,  Maureen Kay REILLY ,  Hunter Paul SHUNATONA ,  James Ross WALKER ,  Mikhail ZIBINSKY ,  James Aaron BALOG ,  David K. Williams ,  Jay A. MARKWALDER ,  Steven P. SEITZ ,  Emily Charlotte CHERNEY ,  Liping ZHANG ,  Weifang SHAN ,  Weiwei GUO ,  Audris HUANG

IPC分类号： A61K31/47 ,  A61P35/00 ,  A61K31/381

CPC分类号： A61K31/47 ,  A61K31/00 ,  A61K31/136 ,  A61K31/166 ,  A61K31/277 ,  A61K31/381 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04 ,  C07K16/18

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.