公开(公告)号：US09598422B2

公开(公告)日：2017-03-21

申请号：US14933879

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Steven P. Seitz ,  Emily Charlotte Cherney ,  Liping Zhang ,  Weifang Shan ,  Weiwei Guo ,  Audris Huang

IPC分类号： C07C255/50 ,  A61K31/277 ,  C07C233/65 ,  C07D487/04 ,  A61K31/166 ,  C07D211/08 ,  A61K31/445 ,  C07C211/45 ,  A61K31/136 ,  C07D215/04 ,  A61K31/47 ,  A61K31/4709 ,  C07D215/233 ,  C07D213/68 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/00

CPC分类号： A61K31/166 ,  A61K31/00 ,  A61K31/136 ,  A61K31/277 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US10206893B2

公开(公告)日：2019-02-19

申请号：US15422118

申请日：2017-02-01

申请人： Flexus Biosciences, Inc.

发明人： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Steven P. Seitz ,  Emily Charlotte Cherney ,  Liping Zhang ,  Weifang Shan ,  Weiwei Guo ,  Audris Huang

IPC分类号： A61K31/166 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  A61K31/4709 ,  C07D487/04 ,  C07C255/50 ,  A61K31/277 ,  C07C233/65 ,  C07D211/08 ,  A61K31/445 ,  C07C211/45 ,  A61K31/136 ,  C07D215/04 ,  A61K31/47 ,  C07D215/233 ,  C07D213/68 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/519 ,  A61K31/00 ,  C07C255/58 ,  C07C275/30 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/74

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US20170143649A1

公开(公告)日：2017-05-25

申请号：US15422118

申请日：2017-02-01

申请人： Flexus Biosciences, Inc.

发明人： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Steven P. Seitz ,  Emily Charlotte Cherney ,  Liping Zhang ,  Weifang Shan ,  Weiwei Guo ,  Audris Huang

IPC分类号： A61K31/166 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  A61K31/4709

CPC分类号： A61K31/47 ,  A61K31/00 ,  A61K31/136 ,  A61K31/166 ,  A61K31/277 ,  A61K31/381 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04 ,  C07K16/18

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

公开(公告)号：US20160137653A1

公开(公告)日：2016-05-19

申请号：US14933879

申请日：2015-11-05

申请人： Flexus Biosciences, Inc.

发明人： Hilary Plake Beck ,  Juan Carlos Jaen ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  James Aaron Balog ,  David K. Williams ,  Jay A. Markwalder ,  Steven P. Seitz ,  Emily Charlotte Cherney ,  Liping Zhang ,  Weifang Shan ,  Weiwei Guo ,  Audris Huang

IPC分类号： C07D487/04 ,  A61K31/277 ,  C07C233/65 ,  A61K31/166 ,  C07D211/08 ,  A61K31/445 ,  C07C211/45 ,  A61K31/136 ,  C07D215/04 ,  A61K31/47 ,  A61K31/4709 ,  C07D215/233 ,  C07D213/68 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07C255/50

CPC分类号： A61K31/166 ,  A61K31/00 ,  A61K31/136 ,  A61K31/277 ,  A61K31/4412 ,  A61K31/445 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07C211/45 ,  C07C217/80 ,  C07C233/10 ,  C07C233/59 ,  C07C233/60 ,  C07C233/65 ,  C07C233/74 ,  C07C255/50 ,  C07C255/58 ,  C07C275/30 ,  C07C2601/14 ,  C07D211/08 ,  C07D213/68 ,  C07D215/04 ,  C07D215/233 ,  C07D487/04

摘要： Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.