摘要:
The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.
摘要:
The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
摘要:
A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine.
摘要:
A nozzle for a low pressure fuel injection that improves the control and size of the spray angle, as well as enhances the atomization of the fuel delivered to the cylinder for an engine.
摘要:
The above objects and advantages are provided for in improved archery bow sight assembly which provides a floating two-pin sight system for sighting a target. According to the invention, a sight assembly body having a forward portion and rear portion is attached directly to the bow. Pivotally attached to the front portion is a floating sight pin. Pivotally attached to the rear portion is a floating peep sight. Movement of the sight pin and peep sight is caused by a sight adjustment lever. Gear teeth on the sight adjustment lever are meshingly engaged with gear teeth on the peep sight arm. The gear teeth of the adjustment lever are indirectly engaged with the sight pin arm via idler gears. This arrangement allows the peep sight and sight pin to move in the same direction as the sight adjustment lever is manipulated. In use, the user views a target through the peep sight and, while maintaining visual contact with the target through the peep sight, intersects the peep sight with the sight pin by manipulation of the sight adjustment lever. Distance indicia located on the back outer wall of the rear portion identify the distance to the target when indicia are aligned with a peep sight.
摘要:
A switch includes three blade contact terminals against which is biased a rotating printed circuit board. The printed circuit board is rotationally moveable with respect to the blade contacts and has conductive elements on a first side of the printed circuit board for selectively contacting the switching contacts in response to the relative rotation between the switching contacts and the printed circuit board. The conductor elements include a tab for extending around the edge of the printed circuit board to a second side of the printed circuit board so as to provide electrically connected regions on both first and second sides of the printed circuit board. An electrically conducting resilient contact abuts the second side of the printed circuit board and biases the printed circuit board against the switching contacts. The tab and resilient contact can be coupled to a ground potential.
摘要:
A low pressure fuel injector capable of atomizing fuel at relatively low pressure is configured to have reduced hydraulic resistance. Reduction in the hydraulic resistance minimizes the pressure drop within the fuel injector and thereby improves atomization of the fuel for improved fuel economy and performance, and decreased emissions.
摘要:
Internal combustion engine (ICE) on-plug ignition coils with transistor drivers located in powertrain control modules (PCM) or other remote locations are prone to high electrical and magnetic interference (EMI) emissions and are subject to interference from other components due to long connecting wires. Ionization detection circuits have even greater sensitivity to EMI because of their very low signal current levels (mioroampere). The present feature of the invention integrates both the coil driver transistor and ionization detection circuits into the on-plug ignition coil. By placing the circuit on top or on the side of the coil, the connection distance from the circuit to the secondary winding is minimized. Thus, the circuit is less susceptible to electrical and electromagnetic noise.
摘要:
A vehicle speed control system having phasing circuitry which provides a sequence of electrical phase steps in response to a comparison of actual vehicle speed to a desired vehicle speed. A stepper motor coupled to a pinion shaft rotates by discrete phase steps in response to the phasing circuitry. An anti-backlash/transfer gear assembly includes a first sprocket gear coupled to a second sprocket gear by integrally formed compression or flexure members which hold the sprocket gears together and a spring assembly which displaces the circumferential teeth of the two sprocket gears relative to one another. Another gear assembly couples rotational movement from the stepper motor to the engine throttle.
摘要:
A reciprocating fuel pump for an internal combustion engine comprising a body having an outer wall defining a pumping chamber and a pair of generally cylindrical projections in fluid communication with the pumping chamber, the projections defining an intake cavity with an intake check valve therein and a discharge cavity with a discharge check valve therein. Elastomeric tubular conduits within the projections form the intake and discharge cavities and are of a flexibility sufficient to provide a collapsing and an expansion of the conduit walls upon relatively small pressure variations resulting from the suction and discharge strokes of the diaphragm. The elastomeric conduits thereby provide pulsating chambers to smooth out the flow of fuel and thereby increase the fuel flow through the fuel pump.