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公开(公告)号：US08202491B2
公开(公告)日：2012-06-19
申请号：US11603347
申请日：2006-11-21
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0877 , Y10T29/49778
摘要： The invention relates to a cartridge for processing a sample and methods for aligning a cartridge. The cartridge includes a processing device for processing a sample, a body having a surface and bounded by at least one edge, and a plurality of positioning members defined by the surface for aligning the processing device relative to a conduit defined by the body between a cartridge input and a cartridge output.
摘要翻译： 本发明涉及用于处理样品的盒和用于对准盒的方法。 所述盒包括用于处理样品的处理装置，具有表面并由至少一个边缘限定的主体以及由所述表面限定的多个定位构件，所述多个定位构件用于使所述处理装置相对于由所述主体限定的导管 输入和墨盒输出。
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公开(公告)号：US09228640B2
公开(公告)日：2016-01-05
申请号：US13158365
申请日：2011-06-10
CPC分类号： F16H3/54 , B25J9/102 , F16H57/08 , F16H2200/0034 , F16H2200/2005 , F16H2200/2035
摘要： A transmission assembly comprises: a motor; a shift actuator mechanism coupled to the motor; a sun gear coupled to an output shaft of the motor; a first magnet assembly coupled to the sun gear; a ring gear assembly coupled to a shift coupler, the shift coupler being configured to engage via the shift actuator mechanism; a second magnet assembly coupled to a housing face plate, the housing face plate being coupled to an output gear box; and a planet carrier coupled to an output pinion in communication with the output gearbox. The planet carrier comprises at least one planet gear. In a first mode, the ring gear is locked to the first magnet assembly and configured to rotate with the sun gear, the ring gear being configured to prevent the rotation of the at least one planet gear about its own axis causing the planet carrier to rotate at the same speed as the sun gear. In a second mode, the ring gear is locked to the second magnet assembly allowing the sun gear to engage the at least one planet gear, the sun gear being configured to rotate the at least one planet gear about its own axis causing the planet carrier to rotate at a reduced speed from the sun gear.
摘要翻译： 传动组件包括：马达; 耦合到电动机的换档致动器机构; 联接到电动机的输出轴的太阳齿轮; 耦合到太阳齿轮的第一磁体组件; 耦合到换档联轴器的齿圈组件，所述变速联轴器构造成经由所述换档致动器机构接合; 耦合到壳体面板的第二磁体组件，所述壳体面板联接到输出齿轮箱; 以及联接到与输出齿轮箱连通的输出小齿轮的行星架。 行星架包括至少一个行星齿轮。 在第一模式中，所述环形齿轮被锁定到所述第一磁体组件并被配置为随着所述太阳齿轮旋转，所述环形齿轮构造成防止所述至少一个行星齿轮围绕其自身轴线旋转，从而使所述行星架旋转 以与太阳齿轮相同的速度。 在第二模式中，所述环形齿轮被锁定到所述第二磁体组件，允许所述太阳齿轮接合所述至少一个行星齿轮，所述太阳齿轮构造成围绕其自身的轴线旋转所述至少一个行星齿轮， 以减速的速度从太阳齿轮旋转。
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公开(公告)号：US20120123297A1
公开(公告)日：2012-05-17
申请号：US13292254
申请日：2011-11-09
申请人： David Brancazio
发明人： David Brancazio
IPC分类号： A61B5/15
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/150022 , A61B5/150167 , A61B5/150175 , A61B5/150267 , A61B5/150343 , A61B5/150389 , A61B5/150412 , A61B5/150534 , A61B5/150732 , A61B5/150946 , A61B5/150969 , A61B5/15105 , A61B5/15107 , A61B5/15115 , A61B5/15142 , A61B5/154 , A61B10/0051 , A61B10/0064 , A61B10/02
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood from subjects. In one aspect, the present invention is directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a substance transfer component (for example, one or more needles or microneedles) and a reduced pressure or vacuum chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some embodiments, the device may contain a “snap dome” or other deformable structure, which may be used, at least in part, to urge or move needles or other suitable substance transfer components into the skin of a subject. In some cases, for example, the device may contain a flexible concave member and a needle mechanically coupled to the flexible concave member.
摘要翻译： 本发明一般涉及用于从物体输送和/或接收诸如血液的物质或物质的系统和方法。 一方面，本发明涉及使用包含物质转移组分（例如，一个或多个针头）的装置从例如皮肤和/或从皮肤下面接受或提取血液的装置和方法 或微针）和在接收血液之前具有小于大气压的内部压力的减压或真空室。 在一些实施例中，该装置可以包含“扣式圆顶”或其它可变形结构，其可以至少部分地用于将针或其它合适的物质转移组件推入或移动到受试者的皮肤中。 在一些情况下，例如，该装置可以包含柔性凹形构件和机械地联接到柔性凹构件的针。
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公开(公告)号：US20080118402A1
公开(公告)日：2008-05-22
申请号：US11603285
申请日：2006-11-21
IPC分类号： G01N11/00
CPC分类号： G01N35/1095
摘要： The invention relates to a system for processing an analyte. The system includes a fluid reservoir, a plurality of sample reservoirs, a plurality of channels, a pump that synchronously draws from the fluid reservoir and the plurality of sample reservoirs to provide a plurality of samples through the plurality of channels and a processing device, for example, a flexural plate wave device, for processing the plurality of samples in the plurality of channels. A valve including a pin disposed beneath a dowel and a pusher pushes the pin toward a fastened dowel, which pinches a portion of the channel disposed therebetween. A socket provides electrical contact to the processing device.
摘要翻译： 本发明涉及一种用于处理分析物的系统。 该系统包括流体储存器，多个样品储存器，多个通道，从流体储存器和多个样品储存器同步抽出的泵，以通过多个通道提供多个样品，以及处理装置，用于 例如，弯曲板波装置，用于处理多个通道中的多个采样。 包括设置在定位销下方的销的阀和推动器将销朝向紧固的销钉推动，该销钉夹持设置在其间的通道的一部分。 插座提供与处理装置的电接触。
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公开(公告)号：US08435463B2
公开(公告)日：2013-05-07
申请号：US13525995
申请日：2012-06-18
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0877 , Y10T29/49778
摘要： An apparatus includes a housing having a support surface to support a cartridge, a socket attached to the housing, and an actuator associated with the socket. The socket surface includes one or more socket positioning members, a plurality of electrical contacts and a plurality of magnets. The socket is configured to move relative to the support surface of the housing, with the one or more socket positioning members located in a fixed relation to the plurality of electrical contacts so that when the socket is spaced proximate to the support surface of the housing, the one or more socket positioning members engage with the one or more cartridge positioning members to align the plurality of electrical contacts of the socket with the plurality of electrical contact pads of the cartridge. The actuator is configured to align each magnet with a respective fluid conduit of the processing device.
摘要翻译： 一种装置包括：壳体，其具有用于支撑盒的支撑表面，附接到壳体的插座和与插座相关联的致动器。 插座表面包括一个或多个插座定位构件，多个电触点和多个磁体。 插座构造成相对于壳体的支撑表面移动，其中一个或多个插座定位构件位于与多个电触点的固定关系中，使得当插座间隔开邻近壳体的支撑表面时， 一个或多个插座定位构件与一个或多个盒定位构件接合，以将插座的多个电触点与盒的多个电接触垫对准。 致动器构造成使每个磁体与处理装置的相应流体导管对准。
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公开(公告)号：US20090269248A1
公开(公告)日：2009-10-29
申请号：US12175037
申请日：2008-07-17
申请人： Peter W. Falb , David Brancazio , Eric France , Brett P. Masters , Michael F. Miller , Joshua R. Ormsby , Walker Sloan
发明人： Peter W. Falb , David Brancazio , Eric France , Brett P. Masters , Michael F. Miller , Joshua R. Ormsby , Walker Sloan
CPC分类号： G01N35/00029 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , B01L2400/0655 , G01N2035/00148 , Y10T29/49
摘要： A system for processing analytes in samples includes an instrument and a cartridge. The cartridge includes fluid inputs, input and output valve assemblies, processing devices, fluid reservoirs, and channels for carrying samples from the fluid inputs to the fluid reservoirs. The valve assemblies include valves adapted to form a sealed fluid chamber in response to force applied by a movable head assembly of the instrument. Each fluid reservoir is adapted to mate and align with an air displacement pump interface member. A valve assembly includes a recess wall surrounding a recess and a valve assembly wall surrounding both the recess and the recess wall. The recess wall and the valve assembly walls are adapted to mate with and seal against a flexible sheet covering the recess, the recess wall, and the valve assembly wall. The cartridge and instrument include complementary features for finely and coarsely aligning instrument assemblies with portions of the cartridge.
摘要翻译： 用于处理样品中分析物的系统包括仪器和墨盒。 墨盒包括流体输入，输入和输出阀组件，处理装置，流体储存器和用于将样品从流体输入传送到流体储存器的通道。 阀组件包括适于响应由仪器的可移动头组件施加的力而形成密封流体室的阀。 每个流体储存器适于与排气泵接口构件配合和对准。 阀组件包括围绕凹部的凹陷壁和围绕凹部和凹陷壁的阀组件壁。 凹陷壁和阀组件壁适于与覆盖凹部，凹陷壁和阀组件壁的柔性薄片配合并密封。 墨盒和仪器包括用于精细和粗略地对准具有部分墨盒的仪器组件的互补特征。
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公开(公告)号：US20080115599A1
公开(公告)日：2008-05-22
申请号：US11603347
申请日：2006-11-21
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2300/0877 , Y10T29/49778
摘要： The invention relates to a cartridge for processing a sample and methods for aligning a cartridge. The cartridge includes a processing device for processing a sample, a body having a surface and bounded by at least one edge, and a plurality of positioning members defined by the surface for aligning the processing device relative to a conduit defined by the body between a cartridge input and a cartridge output.
摘要翻译： 本发明涉及用于处理样品的盒和用于对准盒的方法。 所述盒包括用于处理样品的处理装置，具有表面并由至少一个边缘限定的主体以及由所述表面限定的多个定位构件，所述多个定位构件用于使所述处理装置相对于由所述主体限定的导管 输入和墨盒输出。
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公开(公告)号：US6146567A
公开(公告)日：2000-11-14
申请号：US152442
申请日：1998-09-14
申请人： Emanuel Sachs , Alain Curodeau , Tailin Fan , James F. Bredt , Michael Cima , David Brancazio
发明人： Emanuel Sachs , Alain Curodeau , Tailin Fan , James F. Bredt , Michael Cima , David Brancazio
IPC分类号： B22F3/00 , B29C41/00 , B29C41/12 , B29C41/36 , B29C67/00 , B41J2/01 , B41J2/085 , B41J2/09 , B41J2/505 , B41J2/095 , B05B12/08 , B05C5/00 , B05C11/02 , B44C3/00
CPC分类号： B41J2/505 , B22F3/004 , B22F3/008 , B29C41/006 , B29C41/12 , B29C41/36 , B29C67/0081 , B41J2/01 , B41J2/085 , B41J2/09 , B22F2998/00
摘要： A system for producing three dimensional components by bonding together successive layers of a porous material with droplets of a binder material. A binder printhead has an array of nozzles which controllably supply jets of binder material droplets to the layers of porous material. The printhead is scanned in a raster scan fashion over each layer of porous material along a first scan axis in one direction to provide first fast scanning paths of droplets. The printhead is then moved laterally of such one direction and is then moved along the fast-scan axis in the opposite direction to provide second fast scanning paths of droplets which are interlaced with the first scanning paths. The supply of the droplets to the porous material can be controlled so as to control the overlapping thereof to produce various desired surface and interior characteristics of the components.
摘要翻译： 一种用于通过将多孔材料的连续层与粘合剂材料的液滴结合在一起来生产三维部件的系统。 粘合剂打印头具有可控制地将粘合剂材料液滴喷射到多孔材料层的喷嘴阵列。 打印头以光栅扫描的方式沿着一个方向上的第一扫描轴在每层多孔材料上扫描，以提供液滴的第一快速扫描路径。 然后打印头沿着这样的一个方向横向移动，然后沿着相反方向的快速扫描轴线移动，以提供与第一扫描路径隔行扫描的液滴的第二快速扫描路径。 可以控制向多孔材料的液滴的供应，以便控制其重叠以产生组件的各种所需的表面和内部特性。
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公开(公告)号：US08961902B2
公开(公告)日：2015-02-24
申请号：US12175037
申请日：2008-07-17
申请人： Peter W. Falb , David Brancazio , Eric France , Brett P. Masters , Michael F. Miller , Joshua R. Ormsby , Walker Sloan
发明人： Peter W. Falb , David Brancazio , Eric France , Brett P. Masters , Michael F. Miller , Joshua R. Ormsby , Walker Sloan
CPC分类号： G01N35/00029 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , B01L2400/0655 , G01N2035/00148 , Y10T29/49
摘要： A system for processing analytes in samples includes an instrument and a cartridge. The cartridge includes fluid inputs, input and output valve assemblies, processing devices, fluid reservoirs, and channels for carrying samples from the fluid inputs to the fluid reservoirs. The valve assemblies include valves adapted to form a sealed fluid chamber in response to force applied by a movable head assembly of the instrument. Each fluid reservoir is adapted to mate and align with an air displacement pump interface member. A valve assembly includes a recess wall surrounding a recess and a valve assembly wall surrounding both the recess and the recess wall. The recess wall and the valve assembly walls are adapted to mate with and seal against a flexible sheet covering the recess, the recess wall, and the valve assembly wall. The cartridge and instrument include complementary features for finely and coarsely aligning instrument assemblies with portions of the cartridge.
摘要翻译： 用于处理样品中分析物的系统包括仪器和墨盒。 墨盒包括流体输入，输入和输出阀组件，处理装置，流体储存器和用于将样品从流体输入传送到流体储存器的通道。 阀组件包括适于响应由仪器的可移动头组件施加的力而形成密封流体室的阀。 每个流体储存器适于与排气泵接口构件配合和对准。 阀组件包括围绕凹部的凹陷壁和围绕凹部和凹陷壁的阀组件壁。 凹陷壁和阀组件壁适于与覆盖凹部，凹陷壁和阀组件壁的柔性薄片配合并密封。 墨盒和仪器包括用于精细和粗略地对准具有部分墨盒的仪器组件的互补特征。
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公开(公告)号：US20120053000A1
公开(公告)日：2012-03-01
申请号：US13158365
申请日：2011-06-10
IPC分类号： F16H1/28
CPC分类号： F16H3/54 , B25J9/102 , F16H57/08 , F16H2200/0034 , F16H2200/2005 , F16H2200/2035
摘要： A transmission assembly comprises: a motor; a shift actuator mechanism coupled to the motor; a sun gear coupled to an output shaft of the motor; a first magnet assembly coupled to the sun gear; a ring gear assembly coupled to a shift coupler, the shift coupler being configured to engage via the shift actuator mechanism; a second magnet assembly coupled to a housing face plate, the housing face plate being coupled to an output gear box; and a planet carrier coupled to an output pinion in communication with the output gearbox. The planet carrier comprises at least one planet gear. In a first mode, the ring gear is locked to the first magnet assembly and configured to rotate with the sun gear, the ring gear being configured to prevent the rotation of the at least one planet gear about its own axis causing the planet carrier to rotate at the same speed as the sun gear. In a second mode, the ring gear is locked to the second magnet assembly allowing the sun gear to engage the at least one planet gear, the sun gear being configured to rotate the at least one planet gear about its own axis causing the planet carrier to rotate at a reduced speed from the sun gear.
摘要翻译： 传动组件包括：马达; 耦合到电动机的换档致动器机构; 联接到电动机的输出轴的太阳齿轮; 耦合到太阳齿轮的第一磁体组件; 耦合到换档联轴器的齿圈组件，所述变速联轴器构造成经由所述换档致动器机构接合; 耦合到壳体面板的第二磁体组件，所述壳体面板联接到输出齿轮箱; 以及联接到与输出齿轮箱连通的输出小齿轮的行星架。 行星架包括至少一个行星齿轮。 在第一模式中，所述环形齿轮被锁定到所述第一磁体组件并被配置为随着所述太阳齿轮旋转，所述环形齿轮构造成防止所述至少一个行星齿轮围绕其自身轴线旋转，从而使所述行星架旋转 以与太阳齿轮相同的速度。 在第二模式中，所述环形齿轮被锁定到所述第二磁体组件，允许所述太阳齿轮接合所述至少一个行星齿轮，所述太阳齿轮构造成围绕其自身的轴线旋转所述至少一个行星齿轮， 以减速的速度从太阳齿轮旋转。
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