-
公开(公告)号：US09211269B2
公开(公告)日：2015-12-15
申请号：US13993910
申请日：2011-12-16
申请人： Thomas Chen , Daniel Levin , Satish Pupalli , Daniel A Dickman
发明人： Thomas Chen , Daniel Levin , Satish Pupalli , Daniel A Dickman
IPC分类号： C07C35/18 , A61K31/045 , A61P35/00 , A61K31/05 , A61K45/06 , A61K31/165 , A61K47/48 , A61K31/415 , A61K31/4188 , A61K31/4015 , A61K31/325
CPC分类号： A61K31/045 , A61K31/05 , A61K31/165 , A61K31/325 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K45/06 , A61K47/54 , A61K47/55 , A61N5/10 , C07B2200/07 , C07C271/22 , C07D207/26 , C07D231/12 , C07D487/04 , A61K2300/00
摘要： The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
摘要翻译： 本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜烯或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。 本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。 衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。 给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。
-
公开(公告)号：US08796451B2
公开(公告)日：2014-08-05
申请号：US13107780
申请日：2011-05-13
申请人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William Porter
发明人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William Porter
IPC分类号： C07D239/36 , C07D239/10
CPC分类号： C07D239/10 , A61K9/4866 , A61K31/00 , A61K31/513 , A61K47/10 , A61K47/44 , A61K2300/00
摘要： New crystalline forms of lopinavir are disclosed.
摘要翻译： 公开了新的结晶形式的洛匹那韦。
-
3.发明授权Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]- N 失效制备N-4 - [（取代苯基）烷基杂环基] -N-羟基脲化合物的方法
公开(公告)号：US5580989A
公开(公告)日：1996-12-03
申请号：US472448
申请日：1995-06-07
申请人： James D. Ratajczyk , Juliette K. Busse , Sanjay R. Chemburkar , Daniel A. Dickman , Yi-Yin Ku , Hemantkumar H. Patel , Ramesh R. Patel , David P. Sawick , John N. Starr , Bhadra Shelat , Harry O. Spiwek
发明人： James D. Ratajczyk , Juliette K. Busse , Sanjay R. Chemburkar , Daniel A. Dickman , Yi-Yin Ku , Hemantkumar H. Patel , Ramesh R. Patel , David P. Sawick , John N. Starr , Bhadra Shelat , Harry O. Spiwek
IPC分类号： A61K31/38 , A61K31/381 , A61P29/00 , A61P37/08 , A61P43/00 , B01J27/13 , B01J31/22 , C07D307/52 , C07D333/20 , C07D333/22 , C07D307/36
CPC分类号： C07D333/20 , C07D307/52
摘要： A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante.The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.
摘要翻译： 制备结构I I的化合物的方法，其中A是氧和硫，R 1选自氢，卤素，1至6个碳原子的烷基，1至6个碳原子的烷氧基，以及 三氟甲基，R 2为1-4个碳原子的烷基，其中包括式I化合物：其中X为溴或碘的式II化合物与式III的N-羟基脲化合物： 钯催化剂，随后将由此形成的产物与碱金属异氰酸酯反应。 式I化合物是5-脂氧合酶的抑制剂，因此可用作治疗过敏性和炎性疾病病症的治疗剂。
-
公开(公告)号：US5275950A
公开(公告)日：1994-01-04
申请号：US15873
申请日：1993-02-10
申请人： Daniel A. Dickman , Bruce W. Horrom , Chi-Nung W. Hsiao , M. Robert Leanna , Hormoz Mazdiyasni , Howard E. Morton , Thomas M. Zydowsky , William R. Baker , Stephen L. Condon
发明人： Daniel A. Dickman , Bruce W. Horrom , Chi-Nung W. Hsiao , M. Robert Leanna , Hormoz Mazdiyasni , Howard E. Morton , Thomas M. Zydowsky , William R. Baker , Stephen L. Condon
IPC分类号： A61K38/00 , C07D277/28 , C07D277/46 , C07D295/26 , C07K5/065 , C12P13/04 , C07D241/04 , C12P11/00 , C12P17/12
CPC分类号： C07D277/28 , C07D295/26 , C07K5/06078 , A61K38/00
摘要： Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译： 公开了中间体及其制备方法，其可用于制备下式的肾素抑制化合物：（*化学结构*）（I）其中R是通过氮原子与氮原子键合的含氮杂环 磺酰基，R6是氢，烷氧基，卤素或低级烷基，R7是具有2-7个碳原子的低级烷基，R8是低级烷基，环烷基或芳基或其药学上可接受的酸加成盐。
-
公开(公告)号：US08415328B2
公开(公告)日：2013-04-09
申请号：US13100058
申请日：2011-05-03
申请人： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
发明人： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
CPC分类号： C07D235/18
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
-
公开(公告)号：US20110281900A1
公开(公告)日：2011-11-17
申请号：US13107780
申请日：2011-05-13
申请人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William R. Porter
发明人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William R. Porter
IPC分类号： A61K31/513 , A61P31/18
CPC分类号： C07D239/10 , A61K9/4866 , A61K31/00 , A61K31/513 , A61K47/10 , A61K47/44 , A61K2300/00
摘要： New crystalline forms of lopinavir are disclosed.
摘要翻译： 公开了新的结晶形式的洛匹那韦。
-
公开(公告)号：US07754886B2
公开(公告)日：2010-07-13
申请号：US12364987
申请日：2009-02-03
申请人： David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J Hajduk , Aaron R Kunzer , William J. Mcclellan , David D. Nettesheim , Thorsten K. Oost , Andrew M. Petros , Saul Howard Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
发明人： David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J Hajduk , Aaron R Kunzer , William J. Mcclellan , David D. Nettesheim , Thorsten K. Oost , Andrew M. Petros , Saul Howard Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
IPC分类号： C07C211/00 , A61K31/445
CPC分类号： C07D207/27 , A61K31/18 , A61K31/4015 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C311/51 , C07C323/30 , C07C323/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D203/26 , C07D207/06 , C07D209/08 , C07D209/52 , C07D209/54 , C07D211/22 , C07D211/74 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/78 , C07D215/12 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D239/26 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/56 , C07D277/64 , C07D295/205 , C07D295/26 , C07D317/60 , C07D333/28 , C07D333/56 , C07D333/70 , C07D417/12 , C07D451/02
摘要： N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
摘要翻译： 具有下式的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
-
公开(公告)号：US20080275250A1
公开(公告)日：2008-11-06
申请号：US11597335
申请日：2005-06-02
申请人： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
发明人： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
IPC分类号： C07D235/18
CPC分类号： C07D235/18
摘要： The present invention relates to novel inhibitors or Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
摘要翻译： 本发明涉及新的抑制剂或因子VIIa，IXa，Xa，XIa，特别是因子VIIa，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
-
公开(公告)号：US06608198B2
公开(公告)日：2003-08-19
申请号：US09793536
申请日：2001-02-27
申请人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William Porter
发明人： Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William Porter
IPC分类号： C07D23936
CPC分类号： C07D239/10 , A61K9/4866 , A61K31/00 , A61K31/513 , A61K47/10 , A61K47/44 , A61K2300/00
摘要： New crystalline forms of lopinavir are disclosed.
-
公开(公告)号：US5169961A
公开(公告)日：1992-12-08
申请号：US796298
申请日：1991-11-22
IPC分类号： C07C313/08 , C07C319/14 , C07C319/24 , C07C323/22 , C07D333/56 , C07D497/08
CPC分类号： C07D497/08 , C07C313/08 , C07C319/14 , C07C319/24 , C07D333/56
摘要： A process for the production in high yield of 2-acetylbenzo[.beta.]thiophene and its alkyl and alkoxy substituted derivatives by converting a 2-halobenzaldehyde to a 2,2'-dithiobis(benzaldehyde) intermediate and reacting that intermediate successively with 2,4-pentanedione and chloroacetone in the presence of base.
摘要翻译： 通过将2-卤代苯甲醛转化为2,2'-二硫代双（苯甲醛）中间体并使该中间体依次与2,4和2二硫代双 戊二酮和氯丙酮。
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.034 秒)
