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公开(公告)号:US4006249A
公开(公告)日:1977-02-01
申请号:US602603
申请日:1975-08-06
IPC分类号: A61K31/155
CPC分类号: A61K31/155 , Y10S514/863
摘要: A process for the treatment of psoriasis by systemic administration of 2,6-dihalobenzylideneaminoguanidines is disclosed.
摘要翻译: 公开了一种通过全身给予2,6-二卤代亚苄基氨基胍治疗牛皮癣的方法。
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公开(公告)号:US4229447A
公开(公告)日:1980-10-21
申请号:US44430
申请日:1979-06-04
申请人: William R. Porter
发明人: William R. Porter
摘要: A method of therapeutically administering benzodiazepines by the intraoral, i.e. sublingual or buccal route is disclosed.
摘要翻译: 公开了通过口内,即舌下或口腔途径治疗性施用苯二氮卓类药物的方法。
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公开(公告)号:US20110281900A1
公开(公告)日:2011-11-17
申请号:US13107780
申请日:2011-05-13
申请人: Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William R. Porter
发明人: Daniel A. Dickman , Sanjay Chemburkar , James J. Fort , Rodger F. Henry , David Lechuga-Ballesteros , Yuping Niu , William R. Porter
IPC分类号: A61K31/513 , A61P31/18
CPC分类号: C07D239/10 , A61K9/4866 , A61K31/00 , A61K31/513 , A61K47/10 , A61K47/44 , A61K2300/00
摘要: New crystalline forms of lopinavir are disclosed.
摘要翻译: 公开了新的结晶形式的洛匹那韦。
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公开(公告)号:US07364752B1
公开(公告)日:2008-04-29
申请号:US09709829
申请日:2000-11-10
申请人: James J. Fort , Steven L. Krill , Devalina Law , Yihong Qiu , William R. Porter , Eric A. Schmitt
发明人: James J. Fort , Steven L. Krill , Devalina Law , Yihong Qiu , William R. Porter , Eric A. Schmitt
IPC分类号: A61K8/72 , A61K9/20 , A61K9/48 , A61K31/425 , A61K31/505
CPC分类号: A61K31/425 , A61K9/1641 , A61K9/167 , A61K9/2072 , A61K31/505 , Y10S514/937
摘要: A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved dissolution properties. The solid dispersion may optionally be encapsulated in hard gelatin capsules, compressed into a tablet, or may be granulated with a pharmaceutically acceptable granulating agent. Also disclosed are methods of making said solid dispersion and methods of treating an HIV infection employing said solid dispersion.
摘要翻译: 公开了一种药物组合物,其包含HIV蛋白酶抑制剂在水溶性载体如PEG中的固体分散体,其具有增强的生物利用度和改善的溶出性质。 固体分散体可以任选地包封在硬明胶胶囊中,压制成片剂,或者可以用药学上可接受的制粒剂造粒。 还公开了制备所述固体分散体的方法和使用所述固体分散体治疗HIV感染的方法。
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公开(公告)号:US4106411A
公开(公告)日:1978-08-15
申请号:US609777
申请日:1975-09-02
摘要: In order to achieve a fragmentation device having a highly effective coupling between the fragments and high explosive used therewith, as well as a very lethal incendiary effect when combined with a pyrophoric ingredient, enabling this device to bring about increased devastation upon supplies or equipment of an enemy, we provide in accordance with this invention a novel layered arrangement in which one or more layers of pyrophoric material such as a zirconium alloy are interposed with one or more well-defined layers of high explosive and fragments, thus making possible very high fragment velocities, a high density, uniform pattern of fragments, and most importantly, a wide dispersion of pyrophoric particles with the fragments that serve to cause immediate conflagration of any oils, fuels or other combustibles that are in the vicinity of the target, or which have been released by the action of the fragments thereupon.
摘要翻译: 为了实现具有在片段之间高度有效耦合的碎片装置和与其一起使用的高爆炸物,以及当与自燃成分组合时具有非常致命的燃烧效果,使得该装置能够在供给或设备上产生增加的破坏 敌人,我们根据本发明提供一种新颖的分层布置,其中一层或多层自发性材料如锆合金插入有一个或多个明确定义的高爆炸和碎片层,从而使得可能非常高的碎片速度 ,高密度,均匀的碎片图案,最重要的是,自燃颗粒与碎片的广泛分散,其用于引起目标附近的任何油,燃料或其他可燃物的立即爆燃,或已经 通过片段的动作释放。
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公开(公告)号:US4106410A
公开(公告)日:1978-08-15
申请号:US249458
申请日:1972-04-28
CPC分类号: F42B12/22
摘要: In order to achieve a fragmentation device having a highly effective coupling between the fragments and the high explosive used therewith, we provide in accordance with this invention a novel layered warhead in which uniformly thick layers of fragments are interspersed with well defined layers of detonating, military type explosive, thus defining a desirably low charge-to-metal ratio, and making possible a predictable, uniform pattern as well as very high fragment velocities.
摘要翻译: 为了实现碎片与碎片之间的高效耦合的碎片装置,我们根据本发明提供了一种新颖的分层弹头,其中均匀厚的碎片层间散布着明确的引爆层 因此确定了期望的低电荷 - 金属比例,并且使得可能具有可预测的均匀图案以及非常高的片段速度。
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公开(公告)号:US3590126A
公开(公告)日:1971-06-29
申请号:US3590126D
申请日:1968-04-02
申请人: WILLIAM R PORTER
发明人: PORTER WILLIAM R
IPC分类号: A61K39/00 , A61K39/395 , A61K23/02
CPC分类号: A61K39/39575 , A61K39/0003
摘要: THE PRESENT INVENTION PROVIDES CHITIN ANTIGENS AND USE THEREOF FOR TREATING WARM-BLOODED ANIMALS NORMALLY SUBJECT TO ATTACK BY PARASITIC MEMBERS OF THE CLASS ARACHNIDA TYPICALLY TICKS AND MITES.
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