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    1,3-Bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
    2.
    发明申请
    1,3-Bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders 审中-公开
    1,3-二（取代苯基）-2-丙烯-1-酮及其用于治疗VCAM-1介导的病症的用途

    公开(公告)号：US20060258735A1

    公开(公告)日：2006-11-16

    申请号：US11485940

    申请日：2006-07-13

    申请人： Charles Meng ,  Liming Ni ,  James Sikorski ,  Lee Hoong

    发明人： Charles Meng ,  Liming Ni ,  James Sikorski ,  Lee Hoong

    IPC分类号： A61K31/381

    CPC分类号： C07D409/10 ,  A61K9/0031 ,  A61K9/0034 ,  A61K31/381 ,  A61K31/44 ,  A61K31/505 ,  A61K31/513 ,  A61K45/06 ,  C07C49/796 ,  C07C49/813 ,  C07C49/835 ,  C07C49/84 ,  C07C49/86 ,  C07C205/45 ,  C07D309/06 ,  C07D317/44 ,  C07D333/16 ,  C07D333/56 ,  C07D413/10 ,  C07D417/10 ,  C07D493/04 ,  A61K2300/00

    摘要： It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.

    摘要翻译： 已经发现某些1,3-双（取代苯基）-2-丙烯-1-酮，包括式（I）化合物抑制VCAM-1的表达，因此可用于治疗患有 由VCAM-1介导的病症。 由VCAM-1介导的炎性病症的实例包括但不限于关节炎，哮喘，皮炎，囊性纤维化，移植后晚期和慢性固体器官排斥，多发性硬化，系统性红斑狼疮，炎性肠病，自身免疫性糖尿病， 糖尿病性视网膜病变，鼻炎，缺血再灌注损伤，血管成形术后再狭窄，慢性阻塞性肺疾病（COPD），肾小球性肾炎，格雷夫斯病，胃肠道过敏，结膜炎，动脉粥样硬化，冠状动脉疾病，心绞痛和小动脉疾病。

    Bipolar switching transistor using a Schottky diode clamp
    4.
    发明授权
    Bipolar switching transistor using a Schottky diode clamp 失效
    使用肖特基二极管钳位的双极开关晶体管

    公开(公告)号：US4037115A

    公开(公告)日：1977-07-19

    申请号：US699950

    申请日：1976-06-25

    申请人： Charles Meng-Yuan Lee

    发明人： Charles Meng-Yuan Lee

    IPC分类号： H03K19/088 ,  H03K19/40 ,  H03K5/08

    CPC分类号： H03K19/088

    摘要： A transistor-transistor logic gate is described which uses a number of bipolar switching transistors clamped in several different ways. In particular to better adapt a bipolar switching transistor to high frequency, high temperature operation, the collectors of the various switching transistors are clamped in a variety of novel ways, each to achieve a collector voltage higher than that normally achieved by the conventional Schottky diode clamp connected between the base and collector.

    摘要翻译： 描述了晶体管晶体管逻辑门，其使用以若干不同方式钳位的多个双极性开关晶体管。 特别是为了更好地将双极开关晶体管适应于高频，高温操作，各种开关晶体管的集电极以各种新颖的方式被钳位，每种都采用高于通常由常规肖特基二极管钳位实现的集电极电压 连接在基座和收集器之间。

    INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE
    5.
    发明申请
    INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE 有权
    杀虫剂4-氨基 - 噻吩并[2,3-D] - 嘧啶化合物及其使用方法

    公开(公告)号：US20120252667A1

    公开(公告)日：2012-10-04

    申请号：US13386194

    申请日：2010-07-29

    申请人： Mark David Soll ,  Charles Meng ,  Matthias Pohlman ,  Ernst Baumann ,  Ralph Paulini

    发明人： Mark David Soll ,  Charles Meng ,  Matthias Pohlman ,  Ernst Baumann ,  Ralph Paulini

    IPC分类号： A61K31/519 ,  A01N43/90 ,  A61P33/00 ,  A61P33/14 ,  A01C1/06 ,  A61P33/02 ,  A61P33/06 ,  A01P5/00 ,  A01P7/00 ,  A01P7/04 ,  C07D495/04 ,  A61P33/10

    CPC分类号： C07D495/04 ,  A01N43/90 ,  A01N47/02

    摘要： Insecticidal 4-Amino-thieno[2,3-d]-pyrimidine compounds and methods of their use to control pests that damage plants and crops and parasites that harm animals.The present invention relates to new insecticidal 4-Amino-thieno[2,3-d]-pyrimidine compounds and new methods of their use.The new 4-Amino-thieno[2,3-d]-pyrimidine derivatives have the general formula I: wherein X, R1, R2, R3 and A are defined as in the description.The invention relates also to their enantiomer, diastereomer or agriculturally or veterinary acceptable salt thereof. The invention relates also to agricultural and veterinary compositions comprising such compounds. The invention relates further also to different insecticidal methods applying such compounds and compositions.

    摘要翻译： 杀虫剂4-氨基 - 噻吩并[2,3-d] - 嘧啶化合物及其用于控制​​害虫损害动物的植物和作物和寄生虫的方法。 本发明涉及新的杀虫剂4-氨基 - 噻吩并[2,3-d] - 嘧啶化合物及其使用的新方法。 新的4-氨基 - 噻吩并[2,3-d] - 嘧啶衍生物具有通式I：其中X，R 1，R 2，R 3和A如描述中所定义。 本发明还涉及它们的对映异构体，非对映异构体或农业上或兽医学上可接受的盐。 本发明还涉及包含这种化合物的农业和兽用组合物。 本发明还涉及应用这种化合物和组合物的不同杀虫方法。

    Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
    9.
    发明申请
    Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease 失效
    用于治疗包括关节炎，哮喘和冠状动脉疾病在内的疾病的酚类抗氧化剂

    公开(公告)号：US20060020038A1

    公开(公告)日：2006-01-26

    申请号：US11111196

    申请日：2005-04-20

    申请人： Charles Meng ,  James Sikorski

    发明人： Charles Meng ,  James Sikorski

    IPC分类号： A61K31/165 ,  C07C323/40

    CPC分类号： C07C323/20

    摘要： The invention relates to compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, wherein the compounds are of the following Formulas: or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein the substituents are defined in the application. The invention further provides methods of treatment of inflammatory disorders by administering the compounds.

    摘要翻译： 本发明涉及化合物，包含该化合物的药物组合物和使用该化合物的方法，其中所述化合物具有下列通式：或其药学上可接受的盐，酯或前药，其中取代基在本申请中定义。 本发明还提供了通过施用化合物治疗炎症性疾病的方法。