公开(公告)号：US09687200B2

公开(公告)日：2017-06-27

申请号：US13088289

申请日：2011-04-15

Applicant: Calvin R. Maurer, Jr.

Inventor： Calvin R. Maurer, Jr.

IPC: A61B5/055 ,  A61B6/03 ,  A61N5/10 ,  G01N23/04 ,  A61B6/00

CPC classification number: A61B6/032 ,  A61B5/055 ,  A61B6/4085 ,  A61B6/4405 ,  A61N5/1049 ,  A61N2005/1062 ,  A61N2005/1063

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening and a radiation treatment head coupled to the ring gantry that is rotatable around the central opening in at least a 180 degree arc. For one preferred embodiment, the apparatus further comprises a gantry translation mechanism configured to translate the ring gantry in a direction of a longitudinal axis extending through the central opening. Noncoplanar radiation treatment delivery can thereby be achieved without requiring movement of the patient. For another preferred embodiment, an independently translatable 3D imaging device distinct from the ring gantry is provided for further achieving at least one of pre-treatment imaging and setup imaging of the target tissue volume without requiring movement of the patient.

公开(公告)号：US09044602B2

公开(公告)日：2015-06-02

申请号：US13446883

申请日：2012-04-13

Applicant: Warren D. Kilby ,  Gregory L. Orr ,  Etienne Lessard ,  Colin Sims ,  John R. Dooley ,  Calvin R. Maurer, Jr. ,  Jay B. West

Inventor： Warren D. Kilby ,  Gregory L. Orr ,  Etienne Lessard ,  Colin Sims ,  John R. Dooley ,  Calvin R. Maurer, Jr. ,  Jay B. West

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/10 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1083

Abstract: A method and apparatus for radiation treatment planning are described. The method includes receiving a plurality of radiation treatment-planning parameters, and sequentially optimizing the plurality of radiation treatment-planning parameters.

Abstract translation: 描述了用于放射治疗计划的方法和装置。 该方法包括接收多个辐射治疗计划参数，并顺序优化多个辐射治疗计划参数。

公开(公告)号：US08934605B2

公开(公告)日：2015-01-13

申请号：US13033584

申请日：2011-02-23

Applicant: Calvin R. Maurer, Jr. ,  Euan S. Thomson

Inventor： Calvin R. Maurer, Jr. ,  Euan S. Thomson

IPC: A61N5/10 ,  A61B6/00

CPC classification number: A61N5/1039 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/055 ,  A61B6/025 ,  A61B6/032 ,  A61B6/06 ,  A61B6/4014 ,  A61B6/4085 ,  A61B6/4435 ,  A61B6/4452 ,  A61B6/488 ,  A61N5/10 ,  A61N5/1037 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1092 ,  G01N2223/308

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. Provided according to one preferred embodiment is an IGRT apparatus including a barrel-style rotatable gantry structure that provides high mechanical stability, versatility in radiation delivery, and versatility in target tracking. Methods for treatment radiation delivery using the IGRT apparatus include conical non-coplanar rotational arc therapy and cono-helical non-coplanar rotational arc therapy. A radiation treatment head (MV source) and a treatment guidance imaging system including a kV imaging source are mounted to and rotatable with a common barrel-style rotatable gantry structure, or alternatively the MV and kV sources are mounted to separate barrel-style rotatable gantry structures independently rotatable around a common axis of rotation. Methods for intra-fraction target tracking in a gantry-style IGRT system based on comparisons between a pre-acquired planning image and intrafraction x-ray tomosynthesis images and/or intrafraction cone beam CT (CBCT) images are also described.

Abstract translation: 描述了用于图像引导辐射治疗（IGRT）的系统，方法和相关计算机程序产品。 根据一个优选实施例提供了一种IGRT装置，其包括提供高机械稳定性，辐射传递多功能性和目标跟踪的多功能性的桶式可旋转机架结构。 使用IGRT装置治疗放射线递送的方法包括锥形非共面旋转电弧治疗和螺旋非共面旋转电弧疗法。 放射治疗头（MV源）和包括kV成像源的治疗引导成像系统安装到可旋转的机架式可旋转式结构上并可旋转，或者MV和kV源安装到独立的桶式可旋转机架 可以围绕公共旋转轴线独立地旋转的结构。 还描述了基于预采集的计划图像和分数内X射线断层合成图像和/或分数锥束CT（CBCT）图像之间的比较的龙门式IGRT系统中的部分内目标跟踪的方法。

公开(公告)号：US08917813B2

公开(公告)日：2014-12-23

申请号：US13033571

申请日：2011-02-23

Applicant: Calvin R. Maurer, Jr.

Inventor： Calvin R. Maurer, Jr.

IPC: A61N5/10 ,  A61B6/02 ,  A61B6/00

CPC classification number: A61N5/1039 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/055 ,  A61B6/025 ,  A61B6/032 ,  A61B6/06 ,  A61B6/4014 ,  A61B6/4085 ,  A61B6/4435 ,  A61B6/4452 ,  A61B6/488 ,  A61N5/10 ,  A61N5/1037 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1092 ,  G01N2223/308

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. Provided according to one preferred embodiment is an IGRT apparatus including a barrel-style rotatable gantry structure that provides high mechanical stability, versatility in radiation delivery, and versatility in target tracking. Methods for treatment radiation delivery using the IGRT apparatus include conical non-coplanar rotational arc therapy and cono-helical non-coplanar rotational arc therapy. A radiation treatment head (MV source) and a treatment guidance imaging system including a kV imaging source are mounted to and rotatable with a common barrel-style rotatable gantry structure, or alternatively the MV and kV sources are mounted to separate barrel-style rotatable gantry structures independently rotatable around a common axis of rotation. Methods for intra-fraction target tracking in a gantry-style IGRT system based on comparisons between a pre-acquired planning image and intrafraction x-ray tomosynthesis images and/or intrafraction cone beam CT (CBCT) images are also described.

Abstract translation: 描述了用于图像引导辐射治疗（IGRT）的系统，方法和相关计算机程序产品。 根据一个优选实施例提供了一种IGRT装置，其包括提供高机械稳定性，辐射传递多功能性和目标跟踪的多功能性的桶式可旋转机架结构。 使用IGRT装置治疗放射线递送的方法包括锥形非共面旋转电弧治疗和螺旋非共面旋转电弧疗法。 放射治疗头（MV源）和包括kV成像源的治疗引导成像系统安装到可旋转的机架式可旋转式结构上并可旋转，或者MV和kV源安装到独立的桶式可旋转机架 可以围绕公共旋转轴线独立地旋转的结构。 还描述了基于预采集的计划图像和分数内X射线断层合成图像和/或分数锥束CT（CBCT）图像之间的比较的龙门式IGRT系统中的部分内目标跟踪的方法。

公开(公告)号：US08559596B2

公开(公告)日：2013-10-15

申请号：US13156285

申请日：2011-06-08

Applicant: Euan S. Thomson ,  Calvin R. Maurer, Jr.

Inventor： Euan S. Thomson ,  Calvin R. Maurer, Jr.

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61B6/025 ,  A61B6/032 ,  A61B6/4014 ,  A61B6/4071 ,  A61B6/4085 ,  A61B6/4458 ,  A61B6/482 ,  A61B6/488 ,  A61N5/1049 ,  A61N5/1083 ,  A61N2005/1061 ,  G06T7/0014 ,  G06T7/70 ,  G06T2200/04 ,  G06T2207/10112 ,  G06T2207/30004

Abstract: Systems, methods, and related computer program products for medical imaging and image-guided radiation treatment (IGRT) are described. In one preferred embodiment, an IGRT system provides intrafraction target tracking based on a comparison of intrafraction x-ray tomosynthesis image data with initial x-ray tomosynthesis image data acquired with the patient in an initial treatment position, the initial x-ray tomosynthesis image data having an inherent registration with co-acquired image data from a setup imaging system integral with, or having known geometry relative to, the tomosynthesis imaging system. Repeated registration of intrafraction x-ray tomosynthesis image data with pre-acquired reference image data from a different frame of reference is not required during intrafraction radiation delivery. Advantages include streamlined intrafraction computation and/or reduced treatment delivery margins.

Abstract translation: 描述了用于医学成像和图像引导辐射治疗（IGRT）的系统，方法和相关的计算机程序产品。 在一个优选实施例中，IGRT系统基于将分数内X射线断层合成图像数据与在初始治疗位置中与患者获取的初始x射线断层合成图像数据的比较，初始X射线断层合成图像数据 具有与来自与所述断层摄影成像系统成一体或具有已知几何形状的建立成像系统的共同获取的图像数据的固有配准。 在分组内辐射传递期间，不需要从不同的参照系参考图像数据重新注册分组内x射线断层合成图像数据。 优点包括精简的内分泌计算和/或减少的治疗递送余量。

公开(公告)号：US08536547B2

公开(公告)日：2013-09-17

申请号：US13088321

申请日：2011-04-15

Applicant: Calvin R. Maurer, Jr. ,  Eric P. Lindquist

Inventor： Calvin R. Maurer, Jr. ,  Eric P. Lindquist

IPC: A61N5/00

CPC classification number: A61B6/032 ,  A61B5/055 ,  A61B6/4085 ,  A61B6/4405 ,  A61N5/10 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/0633 ,  A61N2005/1055 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1063

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening sufficiently large to accommodate a body of a patient positioned along a longitudinal axis and extending therethrough, and a gantry tilting mechanism configured to tilt the ring gantry to a plurality of different tilt angles relative to the longitudinal axis. A radiation treatment head is coupled to the ring gantry and is rotatable around said central opening in at least a 180 degree arc. The radiation treatment head is mechanically coupled to the ring gantry such that a distance by which the radiation treatment head extends inwardly toward the central opening relative to the ring gantry is dynamically controllable.

Abstract translation: 描述了用于图像引导辐射治疗（IGRT）的系统，方法和相关计算机程序产品。 对于一个优选实施例，提供了一种IGRT装置，其包括具有足够大的中心开口的环形台架，该中心开口足以容纳沿着纵向轴线定位并延伸穿过其中的患者的身体，以及构造成将环形台架倾斜到多个 相对于纵向轴线具有不同的倾斜角度。 辐射治疗头联接到环形台架并且可以以至少180度的弧度围绕所述中心开口旋转。 放射治疗头机械地联接到环形台架，使得辐射治疗头相对于环形台架向内朝向中心开口延伸的距离是动态可控的。

公开(公告)号：US20130101082A1

公开(公告)日：2013-04-25

申请号：US13536737

申请日：2012-06-28

Applicant: Petr JORDAN ,  Andriy Myronenko ,  Jay B. West ,  Calvin R. Maurer, JR. ,  Prashant Chopra ,  Anuj K. Purwar ,  Christopher A. Janko

Inventor： Petr JORDAN ,  Andriy Myronenko ,  Jay B. West ,  Calvin R. Maurer, JR. ,  Prashant Chopra ,  Anuj K. Purwar ,  Christopher A. Janko

IPC: A61B6/12 ,  A61B6/03

CPC classification number: A61N5/1037 ,  A61B6/022 ,  A61B6/025 ,  A61B6/4035 ,  A61B6/481 ,  A61B6/482 ,  A61B6/5205 ,  A61B6/5211 ,  A61B6/5223 ,  A61B6/583 ,  A61N5/1042 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N5/1083 ,  A61N2005/1061 ,  A61N2005/1062

Abstract: Apparatus for generating multi-energy x-ray images and systems and methods for processing and using multi-energy x-ray images are provided for treating a target, e.g., a tumor, for image-guided radiation therapy. An image-guided radiation therapy system is provided including a treatment delivery system, a multi-energy imaging system, and a system processor. The treatment delivery system includes a radiation source configured to generate treatment radiation beams. The multi-energy imaging system is configured to generate a first set of image data of the patient using imaging radiation at a first energy level and a second set of image data of the patient using imaging radiation at a second energy level. The system processor is configured to process the first and second sets of image data to generate an enhanced image of the patient and to direct the treatment delivery system based on information obtained from the enhanced image.

Abstract translation: 用于产生多能量X射线图像的装置和用于处理和使用多能量X射线图像的系统和方法被提供用于治疗靶，例如肿瘤用于图像引导的放射治疗。 提供了一种图像引导放射治疗系统，包括治疗递送系统，多能量成像系统和系统处理器。 治疗递送系统包括被配置为产生治疗辐射束的辐射源。 多能量成像系统被配置为使用第一能级的成像辐射和使用第二能级的成像辐射的患者的第二组图像数据来产生患者的第一组图像数据。 系统处理器被配置为处理第一和第二组图像数据以生成患者的增强图像，并且基于从增强图像获得的信息来指导治疗传递系统。

公开(公告)号：US20120035462A1

公开(公告)日：2012-02-09

申请号：US13204559

申请日：2011-08-05

Applicant: Calvin R. Maurer, JR. ,  Jay West ,  Petr Jordan

Inventor： Calvin R. Maurer, JR. ,  Jay West ,  Petr Jordan

IPC: A61B8/13 ,  A61B5/055 ,  A61B6/03 ,  A61B8/00

CPC classification number: A61N5/1049 ,  A61B5/055 ,  A61B6/022 ,  A61B6/032 ,  A61B6/0457 ,  A61B6/4417 ,  A61B6/4458 ,  A61B6/5247 ,  A61B8/08 ,  A61B8/085 ,  A61B8/4218 ,  A61B8/4245 ,  A61B8/4263 ,  A61B8/4416 ,  A61B8/4444 ,  A61B8/483 ,  A61B8/5238 ,  A61B8/5261 ,  A61B90/39 ,  A61B2090/3995 ,  A61N5/1039 ,  A61N5/1045 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1083 ,  A61N2005/1054 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1061 ,  A61N2005/1062

Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.

Abstract translation: 提供了用于在放射治疗期间实时跟踪目标体积（例如肿瘤）的系统和方法。 在一个方面，一种系统包括超声波探头，X射线成像仪，处理器和将肿瘤的3D图像存储在第一参考系中的计算机可读介质，以及用于使处理器执行以下操作的指令：指示x 射线成像仪和超声探头基本上同时获得在第二参考系中肿瘤的固有的x射线和设置的超声图像; 通过注册3D图像和X射线图像来建立第一和第二参考帧之间的变换; 指示超声探头获得肿瘤的分数内超声图像; 用建立的超声图像记录影像内图像; 并且基于注册的分数内超声图像跟踪目标体积运动。

公开(公告)号：US08086004B2

公开(公告)日：2011-12-27

申请号：US12199293

申请日：2008-08-27

Applicant: Gopinath Kuduvalli ,  Dongshan Fu ,  Calvin R. Maurer, Jr.

Inventor： Gopinath Kuduvalli ,  Dongshan Fu ,  Calvin R. Maurer, Jr.

IPC: G06K9/00

CPC classification number: G06T7/33 ,  A61B6/4014 ,  A61B6/4452 ,  A61B6/588 ,  A61N5/1049 ,  A61N5/1075 ,  A61N2005/1061 ,  G06T2207/10072 ,  G06T2207/10124 ,  G06T2207/30004

Abstract: A method and system for aligning a volume of interest in a three-dimensional treatment coordinate system with a reference position using stereoscopic imaging data and for monitoring and correcting alignment of the volume of interest in the three-dimensional treatment coordinate system using monoscopic imaging data.

Abstract translation: 一种方法和系统，用于使用立体成像数据将三维处理坐标系中的感兴趣体积与参考位置对准，并且使用单视镜成像数据来监视和校正三维治疗坐标系中感兴趣体积的对准。

公开(公告)号：US20110211665A1

公开(公告)日：2011-09-01

申请号：US13033584

申请日：2011-02-23

Applicant: Calvin R. Maurer, JR. ,  Euan S. Thomson

Inventor： Calvin R. Maurer, JR. ,  Euan S. Thomson

IPC: A61B6/03

CPC classification number: A61N5/1039 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/055 ,  A61B6/025 ,  A61B6/032 ,  A61B6/06 ,  A61B6/4014 ,  A61B6/4085 ,  A61B6/4435 ,  A61B6/4452 ,  A61B6/488 ,  A61N5/10 ,  A61N5/1037 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1061 ,  A61N2005/1062 ,  A61N2005/1092 ,  G01N2223/308

Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. Provided according to one preferred embodiment is an IGRT apparatus including a barrel-style rotatable gantry structure that provides high mechanical stability, versatility in radiation delivery, and versatility in target tracking. Methods for treatment radiation delivery using the IGRT apparatus include conical non-coplanar rotational arc therapy and cono-helical non-coplanar rotational arc therapy. A radiation treatment head (MV source) and a treatment guidance imaging system including a kV imaging source are mounted to and rotatable with a common barrel-style rotatable gantry structure, or alternatively the MV and kV sources are mounted to separate barrel-style rotatable gantry structures independently rotatable around a common axis of rotation. Methods for intra-fraction target tracking in a gantry-style IGRT system based on comparisons between a pre-acquired planning image and intrafraction x-ray tomosynthesis images and/or intrafraction cone beam CT (CBCT) images are also described.

Abstract translation: 描述了用于图像引导辐射治疗（IGRT）的系统，方法和相关计算机程序产品。 根据一个优选实施例提供了一种IGRT装置，其包括提供高机械稳定性，辐射传递多功能性和目标跟踪的多功能性的桶式可旋转机架结构。 使用IGRT装置治疗放射线递送的方法包括锥形非共面旋转电弧治疗和螺旋非共面旋转电弧疗法。 放射治疗头（MV源）和包括kV成像源的治疗引导成像系统安装到可旋转的机架式可旋转式结构上并可旋转，或者MV和kV源安装到独立的桶式可旋转机架 可以围绕公共旋转轴线独立地旋转的结构。 还描述了基于预采集的计划图像和分数内X射线断层合成图像和/或分数锥束CT（CBCT）图像之间的比较的龙门式IGRT系统中的部分内目标跟踪的方法。