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    Abuse-deterrent dosage forms containing esketamine
    1.
    发明授权
    Abuse-deterrent dosage forms containing esketamine 有权

    公开(公告)号：US11992468B2

    公开(公告)日：2024-05-28

    申请号：US18184270

    申请日：2023-03-15

    申请人： Clexio Biosciences Ltd.

    发明人： Derek Moe ,  Randal Seburg ,  Sagar Rane

    IPC分类号： A61K31/135 ,  A61K9/20 ,  G01N30/02

    CPC分类号： A61K31/135 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  G01N2030/027

    摘要： Disclosed herein are immediate release oral dosage forms that contain abuse-deterrent and abuse-resistant features. In particular, the disclosed dosage forms can provide deterrence of abuse by ingestion of multiple individual doses. The disclosed dosage forms can likewise provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses. The dosage forms may also exhibit abuse resistant properties when physically manipulated, and also when physically manipulated and then administered in a manner not consistent with oral dosing. The dosage forms may also exhibit abuse resistant properties when administered in a manner intended to result in administration of the esketamine in a higher than therapeutic dose.

    Gastric residence system
    5.
    发明授权
    Gastric residence system 有权

    公开(公告)号：US11577061B2

    公开(公告)日：2023-02-14

    申请号：US16903765

    申请日：2020-06-17

    申请人： CLEXIO BIOSCIENCES LTD.

    发明人： Avshalom Ben Menachem ,  Ilan Zalit ,  Elijahu Berkovich

    IPC分类号： A61M31/00 ,  A61B5/00 ,  A61K9/00 ,  A61K47/69 ,  A61F2/50 ,  A61F5/41

    摘要： The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being pivotally connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.