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    Long acting gastric residence system
    2.
    发明授权
    Long acting gastric residence system 有权

    公开(公告)号：US11964120B2

    公开(公告)日：2024-04-23

    申请号：US18056387

    申请日：2022-11-17

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Avshalom Ben Menachem ,  Ilan Zalit

    IPC: A61M31/00 ,  A61K9/00 ,  A61J3/07

    CPC classification number: A61M31/002 ,  A61K9/0065 ,  A61J3/07 ,  A61M2210/1053

    Abstract: Provided herein are gastroretentive dosage forms (GRDFs) for extended retention in a human stomach, comprising a body comprising at least two arms, the body configured to transform between a collapsed configuration for ingestion, an expanded configuration for retention within the stomach and a disassembled configuration wherein after a predetermined time period has elapsed, the GRDF disassembles into at least two parts such that each of the disassembled parts of the GRDF is sized for exiting the stomach; and, an erodible insert comprising a therapeutic agent, a diagnostic agent, an electronical device, or a combination thereof.

    Gastric residence system
    5.
    发明授权
    Gastric residence system 有权

    公开(公告)号：US11577061B2

    公开(公告)日：2023-02-14

    申请号：US16903765

    申请日：2020-06-17

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Avshalom Ben Menachem ,  Ilan Zalit ,  Elijahu Berkovich

    IPC: A61M31/00 ,  A61B5/00 ,  A61K9/00 ,  A61K47/69 ,  A61F2/50 ,  A61F5/41

    Abstract: The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being pivotally connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.

    Gastric retentive devices
    6.
    发明授权
    Gastric retentive devices 有权

    公开(公告)号：US11147766B2

    公开(公告)日：2021-10-19

    申请号：US15780420

    申请日：2016-12-01

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Ilan Zalit ,  Avshalom Ben Menachem

    IPC: A61K9/00 ,  A61M31/00 ,  A61K9/48 ,  A61K47/38 ,  A61K47/14 ,  A61K47/34 ,  B29C45/00 ,  B29K1/00 ,  B29K105/00

    Abstract: Provided are devices that are configured for gastric retention for a period of at least six hours (or at least three hours if the subject is in the fasted state) while maintaining their structural integrity and releasing or holding an active or diagnostic agent into or in gastric fluid of a human subject over that period, as well as methods of delivering an agent over an extended period by orally administering such devices to a subject, uses of an enteric polymer in the formation of devices that deliver an agent over an extended period of time, and methods of making such devices.

    Gastric residence system
    7.
    发明授权
    Gastric residence system 有权

    公开(公告)号：US10737079B2

    公开(公告)日：2020-08-11

    申请号：US16465231

    申请日：2017-12-04

    Applicant: CLEXIO BIOSCIENCES LTD.

    Inventor： Avshalom Ben Menachem ,  Ilan Zalit

    IPC: A61M31/00 ,  A61K9/00 ,  A61B5/00 ,  A61K47/69 ,  A61F2/50 ,  A61F5/41

    Abstract: The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being pivotally connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.

    Devices and methods for preparing gastroretentive dosage forms
    9.
    发明授权
    Devices and methods for preparing gastroretentive dosage forms 有权

    公开(公告)号：US10195143B2

    公开(公告)日：2019-02-05

    申请号：US15368274

    申请日：2016-12-02

    Applicant: Clexio Biosciences Ltd.

    Inventor： Ilan Zalit ,  Avshalom Ben Menachem

    IPC: A61K9/00 ,  A61K9/48 ,  A61J3/07

    Abstract: The present disclosure provides a device for self-preparation of a gastroretentive dosage form being capable of transitioning between a collapsed configuration and an expanded configuration, the device comprising an assembly unit including: a compartment configured for accommodating the gastroretentive dosage form in the expanded configuration; and a mechanical system configured for, upon operation of an actuation mechanism: (a) transitioning said gastroretentive dosage form into the collapsed configuration; and (b) locking said collapsed gastroretentive dosage form into the collapsed configuration; wherein the device is configured for being portable.

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