-
1.发明申请Use of Magnesium Stearate Dihydrate for Lubrication of Solid Pharmaceutical Compositions 审中-公开使用硬脂酸镁二水合物用于固体药物组合物的润滑公开(公告)号：US20090232896A1
公开(公告)日：2009-09-17
申请号：US12369013
申请日：2009-02-11
申请人： Stephen H. Wu , Brian K. Cheng , Gary A. Nichols , Jae H. Park
发明人： Stephen H. Wu , Brian K. Cheng , Gary A. Nichols , Jae H. Park
CPC分类号： A61K9/2013
摘要： The invention provides lubricant compositions comprising magnesium stearate dihydrate. The lubricant compositions may be used to lubricate a variety of bioactive formulations including pharmaceutical compositions.
摘要翻译： 本发明提供了包含硬脂酸镁二水合物的润滑剂组合物。 润滑剂组合物可用于润滑各种生物活性制剂，包括药物组合物。
-
公开(公告)号：US20080319197A1
公开(公告)日：2008-12-25
申请号：US12161057
申请日：2007-01-19
IPC分类号： C07D211/56
CPC分类号： C07D211/66
摘要： The present invention relates to a crystalline polymorphic form of remifentanil hydrochloride. The invention also describes methods of preparing a polymorphic form of remifentanil hydrochloride.
摘要翻译： 本发明涉及盐酸瑞芬太尼的结晶多晶型物。 本发明还描述了制备盐酸瑞芬太尼多晶型的方法。
-
公开(公告)号：US20080200680A1
公开(公告)日：2008-08-21
申请号：US12089929
申请日：2006-09-28
申请人： Brian K. Cheng , Stephen H. Wu
发明人： Brian K. Cheng , Stephen H. Wu
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K9/2086
摘要： A method for converting polymorphs of Zolpidem hemitartrate, the method comprising treating tablets comprising Zolpidem hemitartrate with heat and/or moisture.
摘要翻译： 一种用于转化迟发型酒石酸多晶型物的方法，所述方法包括用加热和/或湿气处理含有泽西汀酒精的片剂。
-
公开(公告)号：US5602276A
公开(公告)日：1997-02-11
申请号：US674084
申请日：1996-07-01
IPC分类号： C07F9/38
CPC分类号： C07F9/3813
摘要： A process for preparing N-hydroxyalkylaminomethylphosphonic acid or salts thereof which comprises contacting an alkanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol under suitable reaction conditions to produce a reaction mixture, and hydrolyzing the reaction mixture under acidic or basic conditions. In one embodiment, the N-hydroxyalkylaminomethylphosphonic acid or salts thereof is catalytically oxidized to produce an N-phosphonomethylaminocarboxylic acid or salts thereof.
摘要翻译： 一种N-羟烷基氨基甲基膦酸或其盐的制备方法，其包括在醇的存在下，在合适的反应条件下使链烷醇胺，甲醛和亚磷酸二烷基酯接触以产生反应混合物，并在酸性或碱性条件下水解反应混合物。 在一个实施方案中，N-羟烷基氨基甲基膦酸或其盐被催化氧化以产生N-膦酰基二甲基氨基羧酸或其盐。
-
5.发明授权Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders 失效含有吲哚-2-羧酸盐化合物的组合物，用于治疗中枢神经系统疾病
公开(公告)号：US5229413A
公开(公告)日：1993-07-20
申请号：US830108
申请日：1992-02-03
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.
摘要翻译： 含有某些吲哚-2-羧酸酯化合物和衍生物的组合物被描述为治疗由神经毒性损伤或神经变性疾病，特别是由缺血事件引起的CNS障碍引起的CNS障碍的治疗有效性。 优选的化合物具有式“IMAGE”，其中R 5和R 6各自独立地选自氢，溴，氯和氟，并且其中R 10和R 12各自独立地选自氢和低级烷基及其药学上可接受的盐。
-
6.发明申请公开(公告)号：US20130115285A1
公开(公告)日：2013-05-09
申请号：US13578289
申请日：2011-02-12
CPC分类号： A61K47/36 , A23L29/256 , A23L29/275 , A23P20/105 , A23V2002/00 , A61K47/34 , A23V2200/22 , A23V2250/5026
摘要： An enteric coating composition including about 0.01% to about 10% resin and about 0.01% to about 10% polymer. The enteric coating composition may be applied to a substrate, such as a pharmaceutical, nutraceutical, fruit, vegetable, agricultural product, or industrial product, to form an enteric coating on the substrate. Also provided is a multiple-component system having a first component including a resin and a second component including a polymer, wherein mixing the first component and the second component forms an enteric coating composition having about 0.01% to about 10% resin and about 0.01% to about 10% polymer. Methods for coating a substrate with the enteric coating compositions are also provided.
摘要翻译： 包括约0.01％至约10％的树脂和约0.01％至约10％的聚合物的肠溶包衣组合物。 肠溶剂组合物可以施用于基质如药物，保健品，水果，蔬菜，农产品或工业产品，以在基材上形成肠溶衣。 还提供了具有包括树脂的第一组分和包含聚合物的第二组分的多组分体系，其中混合第一组分和第二组分形成具有约0.01％至约10％树脂和约0.01％ 至约10％的聚合物。 还提供了用肠溶衣组合物涂覆底物的方法。
-
公开(公告)号：US20080319196A1
公开(公告)日：2008-12-25
申请号：US12093517
申请日：2006-10-23
申请人： Brian K. Cheng
发明人： Brian K. Cheng
IPC分类号： C07D211/56
CPC分类号： C07D211/66
摘要： An improved process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, processes of synthesizing intermediates for use in the preparation of synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl, and alfentanil are disclosed. The preparation process requires fewer steps, and results in reduced costs and higher efficiency than processes known in the art for producing remifentanil and carfentanil.
摘要翻译： 提供了一种用于合成鸦片剂或阿片类止痛剂和麻醉剂的改进方法及其中间体。 特别地，公开了合成用于制备合成阿片剂或阿片样物质的中间体的方法，例如瑞芬太尼，卡芬太尼，舒芬太尼，芬太尼和阿芬太尼。 制备方法需要更少的步骤，并且导致降低成本并且比本领域已知的用于生产瑞芬太尼和卡芬太尼的方法更高的效率。
-
8.发明授权Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders 失效含有吲哚-2-羧酸盐化合物的组合物，用于治疗中枢神经系统疾病
公开(公告)号：US5137910A
公开(公告)日：1992-08-11
申请号：US484530
申请日：1990-03-01
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.
摘要翻译： 含有某些吲哚-2-羧酸酯化合物和衍生物的组合物被描述为治疗由神经毒性损伤或神经变性疾病，特别是由缺血事件引起的CNS障碍引起的CNS障碍的治疗有效性。 优选的化合物具有式“IMAGE”，其中R 5和R 6各自独立地选自氢，溴，氯和氟，并且其中R 10和R 12各自独立地选自氢和低级烷基及其药学上可接受的盐。
-
公开(公告)号：US09492395B2
公开(公告)日：2016-11-15
申请号：US13105725
申请日：2011-05-11
申请人： Beverly A. Schad , Brian K. Cheng
发明人： Beverly A. Schad , Brian K. Cheng
CPC分类号： A61K9/2866 , A23G3/343 , A23P20/105 , A23V2002/00 , A23V2200/22 , A23V2250/1578 , A23V2250/188 , A23V2250/51082 , A23V2250/51084 , A61K9/2813 , A61K9/282 , A61K9/2826 , A23V2250/51086 , A23V2250/6406 , A23V2250/6422 , A23V2250/1944 , A23G2200/06 , A23G2200/08
摘要： A film coating composition comprising a cellulosic polymer, an opacifying agent, and a fatty acid is disclosed herein. Also disclosed is a film coating composition comprising a cellulosic polymer, an opacifying agent, a plasticizing agent, and a polyol. The disclosed film coating compositions may be mixed with a solvent to produce a film coating suspension. The film coating suspension can be applied to a substrate, such as a nutritional supplement, pharmaceutical, tablet, capsule, softgel, granule, particle, food confectionary form, agricultural seed, and the like to form a film coating on the substrate. Methods of coating a substrate with the film coating suspensions are also provided.
摘要翻译： 本文公开了包含纤维素聚合物，不透明剂和脂肪酸的薄膜包衣组合物。 还公开了包含纤维素聚合物，不透明剂，增塑剂和多元醇的薄膜包衣组合物。 所公开的薄膜涂料组合物可与溶剂混合以产生薄膜包衣悬浮液。 膜包衣悬浮液可以应用于营养补充剂，药物，片剂，胶囊，软胶囊，颗粒，颗粒，食品糖果形式，农业种子等底物，以在基材上形成薄膜包衣。 还提供了用薄膜包衣悬浮液涂覆基材的方法。
-
公开(公告)号：US5703273A
公开(公告)日：1997-12-30
申请号：US674211
申请日：1996-07-01
IPC分类号： C07F9/38
CPC分类号： C07F9/3813
摘要： A process for preparing N-hydroxyalkylaminomethyl-phosphonic acid or salts thereof which comprises contacting an alkanolamine, formaldehyde and a trialkyl phosphite under suitable reaction conditions to produce a reaction mixture, and hydrolyzing the reaction mixture under neutral, acidic or basic conditions. In one embodiment, the N-hydroxyalkylaminomethylphosphonic acid or salts thereof is catalytically oxidized to produce an N-phosphonomethylaminocarboxylic acid or salts thereof.
摘要翻译： 一种N-羟烷基氨基甲基膦酸或其盐的制备方法，其包括在合适的反应条件下使链烷醇胺，甲醛和亚磷酸三烷基酯接触以产生反应混合物，并在中性，酸性或碱性条件下水解反应混合物。 在一个实施方案中，N-羟烷基氨基甲基膦酸或其盐被催化氧化以产生N-膦酰基二甲基氨基羧酸或其盐。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.025 秒)
