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13 条记录 (耗时 0.012 秒)

    Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
    1.
    发明授权
    Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders 失效
    含有吲哚-2-羧酸盐化合物的组合物，用于治疗中枢神经系统疾病

    公开(公告)号：US5229413A

    公开(公告)日：1993-07-20

    申请号：US830108

    申请日：1992-02-03

    申请人： Nancy M. Gray ,  Brian K. Cheng ,  William F. Hood ,  Michael S. Dappen ,  Alex A. Cordi

    发明人： Nancy M. Gray ,  Brian K. Cheng ,  William F. Hood ,  Michael S. Dappen ,  Alex A. Cordi

    IPC分类号： A61K31/405

    CPC分类号： A61K31/405

    摘要： Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.

    摘要翻译： 含有某些吲哚-2-羧酸酯化合物和衍生物的组合物被描述为治疗由神经毒性损伤或神经变性疾病，特别是由缺血事件引起的CNS障碍引起的CNS障碍的治疗有效性。 优选的化合物具有式“IMAGE”，其中R 5和R 6各自独立地选自氢，溴，氯和氟，并且其中R 10和R 12各自独立地选自氢和低级烷基及其药学上可接受的盐。

    Glycyl urea derivatives as anti-convulsants
    8.
    发明授权
    Glycyl urea derivatives as anti-convulsants 失效
    甘氨酰脲衍生物作为抗惊厥药

    公开(公告)号：US5288905A

    公开(公告)日：1994-02-22

    申请号：US761111

    申请日：1991-09-17

    申请人： Alex A. Cordi ,  Claude L. Gillet

    发明人： Alex A. Cordi ,  Claude L. Gillet

    IPC分类号： C07C275/50 ,  C07C275/48

    CPC分类号： C07C275/50

    摘要： A class of glycyl urea derivatives is described having use in treatment of CNS dysfunctions such as epilepsy and convulsive disorders. Compounds of interest are those of the formula ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group independently selected from hydrido, alkyl, aralkyl, aryloxyalkyl and arylthioalkyl, any one of which groups having a substitutable position may be substituted with one or more radicals selected from halo, alkyl of one to about ten carbon atoms, alkenyl of two to about ten carbon atoms, alkynyl of two to about ten carbon atoms, haloalkyl, alkoxy, alkylthio, alkylsulfinyl and alkylsulfonyl; or a pharmaceutically-acceptable salt thereof; with the proviso that when each of R.sup.1 and R.sup.2 is ethyl, then R.sup.3 and R.sup.4 cannot be hydrido simultaneously.

    摘要翻译： 描述了一类甘氨酰脲衍生物用于治疗CNS功能障碍如癫痫和惊厥性疾病。 感兴趣的化合物是式（*化学结构*）的化合物，其中R 1，R 2，R 3和R 4各自独立地选自氢，烷基，芳烷基，芳氧基烷基和芳硫基烷基，其中任何一个具有可取代位置的基团 被一个或多个选自卤素，1至约10个碳原子的烷基，2至约10个碳原子的烯基，2至约10个碳原子的炔基，卤代烷基，烷氧基，烷硫基，烷基亚磺酰基和烷基磺酰基取代; 或其药学上可接受的盐; 条件是当R 1和R 2各自为乙基时，则R 3和R 4不能同时氢化。