知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

87 条记录 (耗时 0.043 秒)

    Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof
    3.
    发明授权
    Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof 有权

    公开(公告)号：US10428149B2

    公开(公告)日：2019-10-01

    申请号：US15558372

    申请日：2016-03-18

    申请人： UNIVERSITÄT STUTTGART ,  BIONTECH AG

    发明人： Ugur Sahin ,  Roland Kontermann ,  Klaus Pfizenmaier ,  Martin Siegemund ,  Meike Hutt ,  Oliver Seifert

    IPC分类号： C07K16/32 ,  C07K16/28 ,  C07K14/705

    摘要： The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector. Further, the present invention relates to said polypeptides, said nucleic acid or said vector for the use as a medicament or for the use in the diagnosis, prophylaxis or treatment of hyperproliferative disorders and inflammatory disorders.

    AGONISTIC TNF RECEPTOR BINDING AGENTS
    7.
    发明申请
    AGONISTIC TNF RECEPTOR BINDING AGENTS 审中-公开

    公开(公告)号：US20180194849A1

    公开(公告)日：2018-07-12

    申请号：US15538419

    申请日：2016-01-08

    申请人： BIONTECH AG ,  GENMAB A/S

    发明人： Ugur Sahin ,  Friederike Gieseke ,  Isil Altintas ,  David Satijn ,  Paul Parren

    IPC分类号： C07K16/28

    摘要： The present invention relates to binding agents binding to receptors of the TNF superfamily, in particular binding agents binding to at least two different receptors of the TNF superfamily, as well as to their use in medicine. The present invention further relates to nucleic acid molecules encoding such binding agents, to cells comprising such nucleic acid molecules and to pharmaceutical compositions and kits.